FCN3

FCN3
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2J5Z, 2J60, 2J64
Identifiers
Aliases	FCN3 , FCNH, HAKA1, ficolin 3
External IDs	OMIM: 604973 HomoloGene: 130523 GeneCards: FCN3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	27,374,824 bp
RNA expression pattern
	Top expressed in
	right lung; ; upper lobe of left lung; ; lower lobe of lung; ; liver; ; right lobe of liver; ; right ventricle; ; left ventricle; ; metanephric glomerulus; ; left adrenal gland; ; right lobe of thyroid gland;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	antigen binding ; protein binding ; metal ion binding ; carbohydrate binding ; serine-type endopeptidase activity ;
Cellular component	extracellular region ; collagen ; blood microparticle ;
Biological process	complement activation, lectin pathway ; complement activation ; recognition of apoptotic cell ; negative regulation of RNA biosynthetic process ; immune system process ; innate immune response ; proteolysis ;
	Sources:Amigo / QuickGO
Orthologs
	8547
	n/a
	ENSG00000142748
	n/a
	O75636
	n/a
	NM_003665 ; NM_173452
	n/a
	NP_003656 ; NP_775628
	n/a
	Wikidata
View/Edit Human

Last updated December 29, 2023

Ficolin-3 is a protein that in humans is encoded by the FCN3 gene. Ficolin-3 was initially identified as H-ficolin, in which H is after the Hakata antigen that was previously found as an autoantigen in patients who lived in the city of Hakata.^[3]^[4]^[5]

Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.^[5]

Related Research Articles

Humoral immunity is the aspect of immunity that is mediated by macromolecules – including secreted antibodies, complement proteins, and certain antimicrobial peptides – located in extracellular fluids. Humoral immunity is named so because it involves substances found in the humors, or body fluids. It contrasts with cell-mediated immunity. Humoral immunity is also referred to as antibody-mediated immunity.

Mannan-binding lectin serine protease 1 also known as mannose-associated serine protease 1 (MASP-1) is an enzyme that in humans is encoded by the MASP1 gene.

Mannose-binding lectin (MBL), also called mannan-binding lectin or mannan-binding protein (MBP), is a lectin that is instrumental in innate immunity as an opsonin and via the lectin pathway.

C-type lectin domain family 4 member M is a protein that in humans is encoded by the CLEC4M gene. CLEC4M has also been designated as CD299.

4F2 cell-surface antigen heavy chain is a protein that in humans is encoded by the SLC3A2 gene.

Galectin-3-binding protein is a protein that in humans is encoded by the LGALS3BP gene.

Ficolin-2, which was initially identified as L-ficolin, is a protein that in humans is encoded by the FCN2 gene.

Sialic acid-binding Ig-like lectin 12, or Siglec-XII, is a protein that in humans, is encoded by the SIGLEC12 gene.

Ficolin-1, and also commonly termed M-ficolin is a protein that in humans is encoded by the FCN1 gene.

Attractin is a protein that in humans is encoded by the ATRN gene.

C-type lectin domain family 11 member A is a protein that in humans is encoded by the CLEC11A gene.

Mesoderm development LRP chaperone, or MESD, is a protein that in humans is encoded by the MESD gene.

CD205 also called Lymphocyte antigen 75 is a protein that in humans is encoded by the LY75 gene.

C-type lectin domain family 1 member A is a protein that in humans is encoded by the CLEC1A gene.

Sialic acid-binding Ig-like lectin 10 is a protein that in humans is encoded by the SIGLEC10 gene. Siglec-G is often referred to as the murine paralog of human Siglec-10

C-type lectin domain family 2 member B is a protein that in humans is encoded by the CLEC2B gene.

C-type lectin domain family 12 member A is a protein that in humans is encoded by the CLEC12A gene.

The CD302 antigen also known as C-type lectin domain family 13 member A is a protein that in humans is encoded by the CD302 gene.

Ficolins are pattern recognition receptors that bind to acetyl groups present in the carbohydrates of bacterial surfaces and mediate activation of the lectin pathway of the complement cascade.

Intelectins are lectins expressed in humans and other chordates. Humans express two types of intelectins encoded by ITLN1 and ITLN2 genes respectively. Several intelectins bind microbe-specific carbohydrate residues. Therefore, intelectins have been proposed to function as immune lectins. Even though intelectins contain fibrinogen-like domain found in the ficolins family of immune lectins, there is significant structural divergence. Thus, intelectins may not function through the same lectin-complement pathway. Most intelectins are still poorly characterized and they may have diverse biological roles. Human intelectin-1 (hIntL-1) has also been shown to bind lactoferrin, but the functional consequence has yet to be elucidated. Additionally, hIntL-1 is a major component of asthmatic mucus and may be involved in insulin physiology as well.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000142748 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sugimoto R, Yae Y, Akaiwa M, Kitajima S, Shibata Y, Sato H, Hirata J, Okochi K, Izuhara K, Hamasaki N (Sep 1998). "Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin family". J Biol Chem. 273 (33): 20721–7. doi: 10.1074/jbc.273.33.20721 . PMID 9694814.
↑ Akaiwa M, Yae Y, Sugimoto R, Suzuki SO, Iwaki T, Izuhara K, Hamasaki N (Jun 1999). "Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile". J Histochem Cytochem. 47 (6): 777–86. doi:10.1177/002215549904700607. PMID 10330454. S2CID 40514218.
1 2 "Entrez Gene: FCN3 ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)".

Yae Y, Inaba S, Sato H (1991). "Isolation and characterization of a thermolabile beta-2 macroglycoprotein ('thermolabile substance' or 'Hakata antigen') detected by precipitating (auto) antibody in sera of patients with systemic lupus erythematosus". Biochim. Biophys. Acta. 1078 (3): 369–76. doi:10.1016/0167-4838(91)90158-v. PMID 1859827.
Inaba S, Okochi K, Yae Y (1991). "Serological studies of an SLE-associated antigen-antibody system discovered as a precipitation reaction in agarose gel: the HAKATA antigen-antibody system". Fukuoka Igaku Zasshi. 81 (9): 284–91. PMID 2276712.
Matsushita M, Kuraya M, Hamasaki N (2002). "Activation of the lectin complement pathway by H-ficolin (Hakata antigen)". J. Immunol. 168 (7): 3502–6. doi: 10.4049/jimmunol.168.7.3502 . PMID 11907111.
Tsujimura M, Miyazaki T, Kojima E (2003). "Serum concentration of Hakata antigen, a member of the ficolins, is linked with inhibition of Aerococcus viridans growth". Clin. Chim. Acta. 325 (1–2): 139–46. doi:10.1016/S0009-8981(02)00274-7. PMID 12367778.
Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Zeng L, Dai J, Ying K (2003). "Identification of a novel human angiopoietin-like gene expressed mainly in heart". J. Hum. Genet. 48 (3): 159–62. doi: 10.1007/s100380300025 . PMID 12624729.
Clark HF, Gurney AL, Abaya E (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Ota T, Suzuki Y, Nishikawa T (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Anderson NL, Polanski M, Pieper R (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi: 10.1074/mcp.M300127-MCP200 . PMID 14718574.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551 . PMID 15340161.
Gerhard DS, Wagner L, Feingold EA (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Otsuki T, Ota T, Nishikawa T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID 16303743.
Liu T, Qian WJ, Gritsenko MA (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943 . PMID 16335952.
Muzny DM, Scherer SE, Kaul R (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature. 440 (7088): 1194–8. Bibcode:2006Natur.440.1194M. doi: 10.1038/nature04728 . PMID 16641997.
Garlatti V, Belloy N, Martin L (2007). "Structural insights into the innate immune recognition specificities of L- and H-ficolins". EMBO J. 26 (2): 623–33. doi:10.1038/sj.emboj.7601500. PMC 1783469 . PMID 17215869.
Honoré C, Hummelshoj T, Hansen BE (2007). "The innate immune component ficolin 3 (Hakata antigen) mediates the clearance of late apoptotic cells". Arthritis Rheum. 56 (5): 1598–607. doi:10.1002/art.22564. PMID 17469142.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000142748 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9694814-3] Sugimoto R, Yae Y, Akaiwa M, Kitajima S, Shibata Y, Sato H, Hirata J, Okochi K, Izuhara K, Hamasaki N (Sep 1998). "Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin family". J Biol Chem. 273 (33): 20721–7. doi: 10.1074/jbc.273.33.20721 . PMID 9694814.

[pmid10330454-4] Akaiwa M, Yae Y, Sugimoto R, Suzuki SO, Iwaki T, Izuhara K, Hamasaki N (Jun 1999). "Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile". J Histochem Cytochem. 47 (6): 777–86. doi:10.1177/002215549904700607. PMID 10330454. S2CID 40514218.

[entrez-5] 1 2 "Entrez Gene: FCN3 ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)".

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FCN3

Related Research Articles

References

Further reading