FCRL4

FCRL4
Identifiers
Aliases	FCRL4 , CD307d, FCRH4, IGFP2, IRTA1, Fc receptor like 4
External IDs	OMIM: 605876; HomoloGene: 88926; GeneCards: FCRL4; OMA:FCRL4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q23.1 Start 157,573,747 bp [1] End 157,598,085 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell epithelium of nasopharynx testicle mucosa of ileum appendix lymph node tibialis anterior muscle tonsil skin of thigh deltoid muscle n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component integral component of membrane plasma membrane membrane cell surface Biological process adaptive immune response immune system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83417 n/a Ensembl ENSG00000163518 n/a UniProt Q96PJ5 n/a RefSeq (mRNA) NM_031282 n/a RefSeq (protein) NP_112572 n/a Location (UCSC) Chr 1: 157.57 – 157.6 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Fc receptor-like protein 4 is a protein that in humans is encoded by the FCRL4 gene. FCRL4 is an inhibitory receptor expressed on human memory B cells which resides in epithelial tissues. ^{[3] [4] [5]}

References

1. GRCh38: Ensembl release 89: ENSG00000163518 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Hatzivassiliou G, Miller I, Takizawa J, Palanisamy N, Rao PH, Iida S, Tagawa S, Taniwaki M, Russo J, Neri A, Cattoretti G, Clynes R, Mendelsohn C, Chaganti RS, Dalla-Favera R (Apr 2001). "IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy". Immunity. 14 (3): 277–89. doi: 10.1016/S1074-7613(01)00109-1 . PMID   11290337.
4. Davis RS, Wang YH, Kubagawa H, Cooper MD (Aug 2001). "Identification of a family of Fc receptor homologs with preferential B cell expression". Proc Natl Acad Sci U S A. 98 (17): 9772–7. Bibcode:2001PNAS...98.9772D. doi: 10.1073/pnas.171308498 . PMC   55528 . PMID   11493702.
5. "Entrez Gene: FCRL4 Fc receptor-like 4".

Further reading

• Taylor AI, Gould HJ, Sutton BJ, Calvert RA (2007). "The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL". Immunogenetics. 59 (4): 323–8. doi:10.1007/s00251-007-0195-9. PMID   17273841. S2CID   1971426.
• Ehrhardt GR, Hsu JT, Gartland L, et al. (2005). "Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells". J. Exp. Med. 202 (6): 783–91. doi:10.1084/jem.20050879. PMC   2212938 . PMID   16157685.
• Jöhrens K, Shimizu Y, Anagnostopoulos I, et al. (2006). "T-bet-positive and IRTA1-positive monocytoid B cells differ from marginal zone B cells and epithelial-associated B cells in their antigen profile and topographical distribution". Haematologica. 90 (8): 1070–7. PMID   16079106.
• Falini B, Tiacci E, Pucciarini A, et al. (2004). "Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT)". Blood. 102 (10): 3684–92. doi: 10.1182/blood-2003-03-0750 . PMID   12881317.
• Guselnikov SV, Ershova SA, Mechetina LV, et al. (2002). "A family of highly diverse human and mouse genes structurally links leukocyte FcR, gp42 and PECAM-1". Immunogenetics. 54 (2): 87–95. doi:10.1007/s00251-002-0436-x. PMID   12037601. S2CID   9452957.
• Miller I, Hatzivassiliou G, Cattoretti G, et al. (2002). "IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells". Blood. 99 (8): 2662–9. doi: 10.1182/blood.V99.8.2662 . PMID   11929751.