FTSJ3

FTSJ3
Identifiers
Aliases	FTSJ3 , EPCS3, SPB1, FtsJ homolog 3, FtsJ RNA methyltransferase homolog 3, FtsJ RNA 2'-O-methyltransferase 3
External IDs	OMIM: 618411; MGI: 1860295; HomoloGene: 5451; GeneCards: FTSJ3; OMA:FTSJ3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	63,830,012 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	106,146,905 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; sural nerve; ; tendon of biceps brachii; ; stromal cell of endometrium; ; gastric mucosa; ; right ovary; ; right adrenal gland; ; right lobe of thyroid gland; ; body of uterus; ; canal of the cervix;
	Top expressed in
	tail of embryo; ; genital tubercle; ; epiblast; ; ventricular zone; ; yolk sac; ; blastocyst; ; embryo; ; zygote; ; morula; ; morula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity ; transferase activity ; rRNA methyltransferase activity ; protein binding ; RNA binding ; rRNA (uridine-2'-O-)-methyltransferase activity ; rRNA (guanine) methyltransferase activity ;
Cellular component	nucleus ; nucleolus ; preribosome, large subunit precursor ; preribosome, small subunit precursor ;
Biological process	rRNA processing ; methylation ; RNA methylation ; ribosome biogenesis ; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ; rRNA methylation ; enzyme-directed rRNA 2'-O-methylation ;
	Sources:Amigo / QuickGO
Orthologs
	117246
	56095
	ENSG00000108592
	ENSMUSG00000020706
	Q8IY81
	Q9DBE9
	NM_017647
	NM_025310
	NP_060117
	NP_079586
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 12, 2024

pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3 is an enzyme, an O-methyltransferase, that in humans is encoded by the FTSJ3 gene.^[5]

Function

The enzyme performs 2′-O-methylation of RNA using S-adenosylmethionine as methyl donor.

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000108592 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020706 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "FTSJ3 FtsJ RNA 2'-O-methyltransferase 3 [ Homo sapiens (human) ]" . Retrieved 8 August 2024.

Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617 . PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC 1459365 . PMID 16565220.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000108592 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020706 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "FTSJ3 FtsJ RNA 2'-O-methyltransferase 3 [ Homo sapiens (human) ]" . Retrieved 8 August 2024.

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FTSJ3

Contents

Function

Related Research Articles

References

Further reading