Fellutamides are tripeptide derivatives from Penicillium fellutanum and other fungi. They are potent proteasome inhibitor that stimulates nerve growth factor synthesis in vitro . [1] [2]
Fellutamides A and F were first isolated from Aspergillus versicolor . [3] [4] Fellutamides C and D were first isolated from an undescribed Metulocladosporiella (Chaetothyriales). [5]
Fellutamide B strongly inhibits the growth of the tuberculosis-causing bacterium Mycobacterium tuberculosis . [6] Its biosynthetic pathway has been determined in the filamentous fungus Aspergillus nidulans . [7]