G3BP2

G3BP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5DRV
Identifiers
Aliases	G3BP2 , G3BP stress granule assembly factor 2
External IDs	MGI: 2442040 HomoloGene: 137244 GeneCards: G3BP2
Gene location (Human)
Chr.	Chromosome 4 (human)
End	75,724,589 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	92,231,578 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; islet of Langerhans; ; Achilles tendon; ; frontal pole; ; pons; ; germinal epithelium; ; superior vestibular nucleus; ; prefrontal cortex; ; ganglionic eminence; ; Brodmann area 10;
	Top expressed in
	secondary oocyte; ; blood; ; anterior horn of spinal cord; ; nucleus accumbens; ; abdominal wall; ; facial motor nucleus; ; neural tube; ; ganglionic eminence; ; medial ganglionic eminence; ; ventral tegmental area;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	signaling receptor complex adaptor activity ; protein binding ; nucleic acid binding ; mRNA binding ; RNA binding ;
Cellular component	intracellular anatomical structure ; cytoplasm ; cytosol ; ribonucleoprotein complex ; cytoplasmic stress granule ;
Biological process	mRNA transport ; Ras protein signal transduction ; cytoplasmic sequestering of NF-kappaB ; stress granule assembly ; transport ; positive regulation of signal transduction ; viral process ; protein homooligomerization ; positive regulation of stress granule assembly ; immune system process ; innate immune response ;
	Sources:Amigo / QuickGO
Orthologs
	9908
	23881
	ENSG00000138757
	ENSMUSG00000029405
	Q9UN86
	P97379
	NM_012297 ; NM_203504 ; NM_203505
NM_001080794 ; NM_001080795 ; NM_001080796 ; NM_001080797 ; NM_011816 ;
	NM_001359195 ; NM_001359196 ; NM_001359197
	NP_036429 ; NP_987100 ; NP_987101 ; NP_987100.1
NP_001074263 ; NP_001074264 ; NP_001074265 ; NP_001074266 ; NP_035946 ;
	NP_001346124 ; NP_001346125 ; NP_001346126
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 03, 2023

Ras GTPase-activating protein-binding protein 2 is an enzyme that in humans is encoded by the G3BP2 gene.^[5]^[6]^[7]

Interactions

G3BP2 has been shown to interact with IκBα.^[8]

Related Research Articles

NF-kappa-B essential modulator (NEMO) also known as inhibitor of nuclear factor kappa-B kinase subunit gamma (IKK-γ) is a protein that in humans is encoded by the IKBKG gene. NEMO is a subunit of the IκB kinase complex that activates NF-κB. The human gene for IKBKG is located on the chromosome band Xq28. Multiple transcript variants encoding different isoforms have been found for this gene.

Nuclear factor NF-kappa-B p105 subunit is a protein that in humans is encoded by the NFKB1 gene.

<span class="mw-page-title-main">IκBα</span> Protein-coding gene in the species Homo sapiens

IκBα is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor. IκBα inhibits NF-κB by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm. In addition, IκBα blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-κB's proper functioning.

Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.

RAS p21 protein activator 1 or RasGAP, also known as RASA1, is a 120-kDa cytosolic human protein that provides two principal activities:

NF-kappa-B inhibitor beta is a protein that in humans is encoded by the NFKBIB gene.

Cytoplasmic protein NCK1 is a protein that in humans is encoded by the NCK1 gene.

Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the ARHGAP1 gene.

Tyrosine-protein phosphatase non-receptor type 13 is an enzyme that in humans is encoded by the PTPN13 gene.

Rac2 is a small signaling G protein, and is a member of the Rac subfamily of the family Rho family of GTPases. It is encoded by the gene RAC2.

TBK1 is an enzyme with kinase activity. Specifically, it is a serine / threonine protein kinase. It is encoded by the TBK1 gene in humans. This kinase is mainly known for its role in innate immunity antiviral response. However, TBK1 also regulates cell proliferation, apoptosis, autophagy, and anti-tumor immunity. Insufficient regulation of TBK1 activity leads to autoimmune, neurodegenerative diseases or tumorigenesis.

Heterogeneous nuclear ribonucleoprotein A/B, also known as HNRNPAB, is a protein which in humans is encoded by the HNRNPAB gene. Although this gene is named HNRNPAB in reference to its first cloning as an RNA binding protein with similarity to HNRNP A and HNRNP B, it is not a member of the HNRNP A/B subfamily of HNRNPs, but groups together closely with HNRNPD/AUF1 and HNRNPDL.

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon, also known as NFKBIE, is a protein which in humans is encoded by the NFKBIE gene.

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the ASAP2 gene.

Ras GTPase-activating protein 3 is an enzyme that in humans is encoded by the RASA3 gene.

RalBP1-associated Eps domain-containing protein 1 is a protein that in humans is encoded by the REPS1 gene.

SH3 domain-binding protein 1 is a protein that in humans is encoded by the SH3BP1 gene.

Ras GTPase-activating protein nGAP is an enzyme that in humans is encoded by the RASAL2 gene.

Ras-related protein Rab-37 is a protein that in humans is encoded by the RAB37 gene.

Ras-related GTP-binding protein B is a protein that in humans is encoded by the RRAGB gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000138757 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029405 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, et al. (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID 9734811.
↑ Kennedy D, Wood SA, Ramsdale T, Tam PP, Steiner KA, Mattick JS (June 1998). "Identification of a mouse orthologue of the human ras-GAP-SH3-domain binding protein and structural confirmation that these proteins contain an RNA recognition motif". Biomedical Peptides, Proteins & Nucleic Acids. 2 (3): 93–9. PMID 9575347.
↑ "Entrez Gene: G3BP2 GTPase activating protein (SH3 domain) binding protein 2".
↑ Prigent M, Barlat I, Langen H, Dargemont C (November 2000). "IkappaBalpha and IkappaBalpha /NF-kappa B complexes are retained in the cytoplasm through interaction with a novel partner, RasGAP SH3-binding protein 2". The Journal of Biological Chemistry. 275 (46): 36441–9. doi: 10.1074/jbc.M004751200 . PMID 10969074.

Kim MM, Wiederschain D, Kennedy D, Hansen E, Yuan ZM (June 2007). "Modulation of p53 and MDM2 activity by novel interaction with Ras-GAP binding proteins (G3BP)". Oncogene. 26 (29): 4209–15. doi:10.1038/sj.onc.1210212. PMID 17297477.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Ong SE, Mittler G, Mann M (November 2004). "Identifying and quantifying in vivo methylation sites by heavy methyl SILAC". Nature Methods. 1 (2): 119–26. doi:10.1038/nmeth715. PMID 15782174. S2CID 6654604.
Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (November 2004). "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID 15345747.
Prigent M, Barlat I, Langen H, Dargemont C (November 2000). "IkappaBalpha and IkappaBalpha /NF-kappa B complexes are retained in the cytoplasm through interaction with a novel partner, RasGAP SH3-binding protein 2". The Journal of Biological Chemistry. 275 (46): 36441–9. doi: 10.1074/jbc.M004751200 . PMID 10969074.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, et al. (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146 . PMID 9110174.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000138757 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029405 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9734811-5] Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, et al. (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID 9734811.

[pmid9575347-6] Kennedy D, Wood SA, Ramsdale T, Tam PP, Steiner KA, Mattick JS (June 1998). "Identification of a mouse orthologue of the human ras-GAP-SH3-domain binding protein and structural confirmation that these proteins contain an RNA recognition motif". Biomedical Peptides, Proteins & Nucleic Acids. 2 (3): 93–9. PMID 9575347.

[entrez-7] "Entrez Gene: G3BP2 GTPase activating protein (SH3 domain) binding protein 2".

[pmid10969074-8] Prigent M, Barlat I, Langen H, Dargemont C (November 2000). "IkappaBalpha and IkappaBalpha /NF-kappa B complexes are retained in the cytoplasm through interaction with a novel partner, RasGAP SH3-binding protein 2". The Journal of Biological Chemistry. 275 (46): 36441–9. doi: 10.1074/jbc.M004751200 . PMID 10969074.

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G3BP2

Contents

Interactions

Related Research Articles

References

Further reading