GAL3ST1

GAL3ST1
Identifiers
Aliases	GAL3ST1 , CST, galactose-3-O-sulfotransferase 1
External IDs	OMIM: 602300 MGI: 1858277 HomoloGene: 3574 GeneCards: GAL3ST1
Gene location (Human)
Chr.	Chromosome 22 (human)
End	30,574,665 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	3,949,326 bp
RNA expression pattern
	Top expressed in
	tibial nerve; ; putamen; ; duodenum; ; nucleus accumbens; ; amygdala; ; caudate nucleus; ; substantia nigra; ; sural nerve; ; jejunal mucosa; ; hippocampus proper;
	Top expressed in
	pyloric antrum; ; Epithelium of stomach; ; mucous cell of stomach; ; duodenum; ; anterior horn of spinal cord; ; sciatic nerve; ; optic nerve; ; proximal tubule; ; jejunum; ; left colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity ; sulfotransferase activity ; galactosylceramide sulfotransferase activity ;
Cellular component	integral component of membrane ; Golgi membrane ; Golgi apparatus ; integral component of plasma membrane ; membrane ;
Biological process	glycolipid biosynthetic process ; myelination ; galactosylceramide biosynthetic process ; protein N-linked glycosylation ; spermatogenesis ; sphingolipid metabolic process ; lipid metabolism ;
	Sources:Amigo / QuickGO
Orthologs
	9514
	53897
	ENSG00000128242
	ENSMUSG00000049721
	Q99999
	Q9JHE4
NM_004861 ; NM_001318103 ; NM_001318104 ; NM_001318105 ; NM_001318106 ;
	NM_001318107 ; NM_001318108 ; NM_001318109 ; NM_001318110 ; NM_001318111 ; NM_001318112 ; NM_001318113 ; NM_001318114 ; NM_001318115 ; NM_001318116
	NM_001177691 ; NM_001177703 ; NM_016922 ; NM_001382290 ; NM_001382291
NP_001305032 ; NP_001305033 ; NP_001305034 ; NP_001305035 ; NP_001305036 ;
	NP_001305037 ; NP_001305038 ; NP_001305039 ; NP_001305040 ; NP_001305041 ; NP_001305042 ; NP_001305043 ; NP_001305044 ; NP_001305045 ; NP_004852
	NP_001171162 ; NP_001171174 ; NP_058618 ; NP_001369219 ; NP_001369220
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 05, 2023

Galactosylceramide sulfotransferase is an enzyme that in humans is encoded by the GAL3ST1 gene.^[5]^[6]^[7]

Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma.^[7]

Related Research Articles

<span class="mw-page-title-main">3'-Phosphoadenosine-5'-phosphosulfate</span> Chemical compound

3′-Phosphoadenosine-5′-phosphosulfate (PAPS) is a derivative of adenosine monophosphate (AMP) that is phosphorylated at the 3′ position and has a sulfate group attached to the 5′ phosphate. It is the most common coenzyme in sulfotransferase reactions and hence part of sulfation pathways. It is endogenously synthesized by organisms via the phosphorylation of adenosine 5′-phosphosulfate (APS), an intermediary metabolite. In humans such reaction is performed by bifunctional 3′-phosphoadenosine 5′-phosphosulfate synthases using ATP as the phosphate donor.

Arylsulfatase A is an enzyme that breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. In humans, arylsulfatase A is encoded by the ARSA gene.

Bradykinin receptor B1 (B₁) is a G-protein coupled receptor encoded by the BDKRB1 gene in humans. Its principal ligand is bradykinin, a 9 amino acid peptide generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The B₁ receptor is one of two of G protein-coupled receptors that have been found which bind bradykinin and mediate responses to these pathophysiologic conditions.

In enzymology, a galactosylceramide sulfotransferase is an enzyme that catalyzes the chemical reaction

Flotillin-1 is a protein that in humans is encoded by the FLOT1 gene.

Sterol O-acyltransferase 2, also known as SOAT2, is an enzyme that in humans is encoded by the SOAT2 gene.

Peroxisomal acyl-coenzyme A oxidase 1 is an enzyme that in humans is encoded by the ACOX1 gene.

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 is an enzyme that in humans is encoded by the PAPSS1 gene.

Sulfotransferase 4A1 is an enzyme that in humans is encoded by the SULT4A1 gene.

Carbohydrate sulfotransferase 2 is an enzyme that in humans is encoded by the CHST2 gene.

Carbohydrate sulfotransferase 1 is an enzyme that in humans is encoded by the CHST1 gene.

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 is an enzyme that in humans is encoded by the PAPSS2 gene.

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 is an enzyme that in humans is encoded by the B3GAT3 gene.

Sulfotransferase family cytosolic 1B member 1 is an enzyme that in humans is encoded by the SULT1B1 gene.

Galactose-3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the GAL3ST2 gene.

Beta-1,4 N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the B4GALNT1 gene.

Galactose-3-O-sulfotransferase 3 is an enzyme that in humans is encoded by the GAL3ST3 gene.

Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 is an enzyme that in humans is encoded by the NDST3 gene. It catalyses the reaction:

3'-phosphoadenylyl sulfate + α-D-glucosaminyl-[heparan sulfate]_(n) = adenosine 3',5'-bisphosphate + 2 H⁺ + N-sulfo-α-D-glucosaminyl-[heparan sulfate]_(n)

Carbohydrate sulfotransferase 10 is an enzyme that in humans is encoded by the CHST10 gene.

Bile salt sulfotransferase also known as hydroxysteroid sulfotransferase (HST) or sulfotransferase 2A1 (ST2A1) is an enzyme that in humans is encoded by the SULT2A1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000128242 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049721 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sanger Centre, The; Washington University Genome Sequencing Cente, The (Jan 1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID 9847074.
↑ Honke K, Tsuda M, Hirahara Y, Ishii A, Makita A, Wada Y (Apr 1997). "Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase". J Biol Chem. 272 (8): 4864–8. doi: 10.1074/jbc.272.8.4864 . PMID 9030544.
1 2 "Entrez Gene: GAL3ST1 galactose-3-O-sulfotransferase 1".

Siegrist HP, Jutzi H, Steck AJ, et al. (1977). "Age-dependent modulation of 3'-phosphoadenosine-5'-phosphosulfate-galactosylceramide sulfotransferase by lipids extracted from the microsomal membranes and artificial lipid mixtures". Biochim. Biophys. Acta. 489 (1): 58–63. doi:10.1016/0005-2760(77)90231-4. PMID 911873.
Stein C, Gieselmann V, Kreysing J, et al. (1989). "Cloning and expression of human arylsulfatase A". J. Biol. Chem. 264 (2): 1252–9. doi: 10.1016/S0021-9258(19)85079-2 . PMID 2562955.
Fleischer B, Zambrano F (1973). "Localization of cerebroside-sulfotransferase activity in the Golgi apparatus of rat kidney". Biochem. Biophys. Res. Commun. 52 (3): 951–8. doi:10.1016/0006-291X(73)91029-2. PMID 4710574.
Farrell DF, McKhann GM (1971). "Characterization of cerebroside sulfotransferase from rat brain". J. Biol. Chem. 246 (15): 4694–702. doi: 10.1016/S0021-9258(18)61991-X . PMID 5562350.
Costantino-Ceccarini E, Waehneldt TV, Ginalski H, et al. (1982). "Distribution of lipid synthesizing enzymes, 2',3'-cyclic nucleotide 3'-phosphodiesterase, and myelin proteins in rat forebrain subfractions during development". Neurochem. Res. 7 (1): 1–12. doi:10.1007/BF00965064. PMID 6280086. S2CID 32069166.
Benjamins JA, Hadden T, Skoff RP (1982). "Cerebroside sulfotransferase in Golgi-enriched fractions from rat brain". J. Neurochem. 38 (1): 233–41. doi:10.1111/j.1471-4159.1982.tb10875.x. PMID 6955451. S2CID 23693243.
Honke K, Yamane M, Ishii A, et al. (1996). "Purification and characterization of 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase from human renal cancer cells". J. Biochem. 119 (3): 421–7. doi:10.1093/oxfordjournals.jbchem.a021258. PMID 8830034.
Tsuda M, Egashira M, Niikawa N, et al. (2000). "Cancer-associated alternative usage of multiple promoters of human GalCer sulfotransferase gene". Eur. J. Biochem. 267 (9): 2672–9. doi: 10.1046/j.1432-1327.2000.01281.x . PMID 10785389.
Eckhardt M, Fewou SN, Ackermann I, Gieselmann V (2002). "N-glycosylation is required for full enzymic activity of the murine galactosylceramide sulphotransferase". Biochem. J. 368 (Pt 1): 317–24. doi:10.1042/BJ20020946. PMC 1222978 . PMID 12175333.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604 . PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000128242 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049721 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9847074-5] Sanger Centre, The; Washington University Genome Sequencing Cente, The (Jan 1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID 9847074.

[pmid9030544-6] Honke K, Tsuda M, Hirahara Y, Ishii A, Makita A, Wada Y (Apr 1997). "Molecular cloning and expression of cDNA encoding human 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase". J Biol Chem. 272 (8): 4864–8. doi: 10.1074/jbc.272.8.4864 . PMID 9030544.

[entrez-7] 1 2 "Entrez Gene: GAL3ST1 galactose-3-O-sulfotransferase 1".

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GAL3ST1

Related Research Articles

References

Further reading