GALNAC4S-6ST

Last updated
CHST15
Identifiers
Aliases CHST15 , BRAG, GALNAC4S-6ST, carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15, carbohydrate sulfotransferase 15
External IDs OMIM: 608277 MGI: 1924840 HomoloGene: 8908 GeneCards: CHST15
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001270764
NM_001270765
NM_014863
NM_015892

NM_029935
NM_001360768

RefSeq (protein)

NP_001257693
NP_001257694
NP_055678
NP_056976

NP_084211
NP_001347697

Location (UCSC) Chr 10: 124.01 – 124.09 Mb Chr 7: 131.84 – 131.92 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Carbohydrate sulfotransferase 15 is an enzyme that in humans is encoded by the CHST15 gene. [5] [6] [7] [8] It belongs to the N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase enzyme class.

Related Research Articles

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Carbohydrate sulfotransferase 2 is an enzyme that in humans is encoded by the CHST2 gene.

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Carbohydrate sulfotransferase 4 is an enzyme that in humans is encoded by the CHST4 gene.

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<span class="mw-page-title-main">GAL3ST2</span>

Galactose-3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the GAL3ST2 gene.

<span class="mw-page-title-main">CHST11</span>

Carbohydrate sulfotransferase 11 is an enzyme that in humans is encoded by the CHST11 gene.

<span class="mw-page-title-main">HS3ST3A1</span> Protein-coding gene in the species Homo sapiens

Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 is an enzyme that in humans is encoded by the HS3ST3A1 gene.

<span class="mw-page-title-main">CHST12</span>

Carbohydrate sulfotransferase 12 is an enzyme that in humans is encoded by the CHST12 gene.

<span class="mw-page-title-main">HS2ST1</span> Enzyme

Heparan sulfate 2-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS2ST1 gene.

<span class="mw-page-title-main">HS3ST3B1</span> Protein-coding gene in the species Homo sapiens

Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 is an enzyme that in humans is encoded by the HS3ST3B1 gene. Heparan sulfate biosynthetic enzymes are key components in generating myriad distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity ( HS3ST3A1). The Sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1 and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta.

<span class="mw-page-title-main">CSPG5</span>

Chondroitin sulfate proteoglycan 5 is a protein that in humans is encoded by the CSPG5 gene.

<span class="mw-page-title-main">CHSY1</span>

Chondroitin sulfate synthase 1 is an enzyme that in humans is encoded by the CHSY1 gene.

<span class="mw-page-title-main">CHST7</span> Protein-coding gene in the species Homo sapiens

Carbohydrate sulfotransferase 7 is an enzyme that in humans is encoded by the CHST7 gene.

<span class="mw-page-title-main">GAL3ST3</span>

Galactose-3-O-sulfotransferase 3 is an enzyme that in humans is encoded by the GAL3ST3 gene.

<span class="mw-page-title-main">CHST10</span>

Carbohydrate sulfotransferase 10 is an enzyme that in humans is encoded by the CHST10 gene.

<span class="mw-page-title-main">HS3ST2</span>

Heparan sulfate glucosamine 3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the HS3ST2 gene.

<span class="mw-page-title-main">CHST14</span>

Carbohydrate sulfotransferase 14 is an enzyme that in humans is encoded by the CHST14 gene.

<span class="mw-page-title-main">Carbohydrate sulfotransferase</span>

Carbohydrate sulfotransferases are sulfotransferase enzymes that transfer sulfate to carbohydrate groups in glycoproteins and glycolipids. Carbohydrates are used by cells for a wide range of functions from structural purposes to extracellular communication. Carbohydrates are suitable for such a wide variety of functions due to the diversity in structure generated from monosaccharide composition, glycosidic linkage positions, chain branching, and covalent modification. Possible covalent modifications include acetylation, methylation, phosphorylation, and sulfation. Sulfation, performed by carbohydrate sulfotransferases, generates carbohydrate sulfate esters. These sulfate esters are only located extracellularly, whether through excretion into the extracellular matrix (ECM) or by presentation on the cell surface. As extracellular compounds, sulfated carbohydrates are mediators of intercellular communication, cellular adhesion, and ECM maintenance.

N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase is an enzyme with systematic name 3'-phosphoadenylyl-sulfate:(dermatan)-4-O-sulfo-N-acetyl-D-galactosamine 6-O-sulfotransferase. This enzyme catalyses the following chemical reaction

<span class="mw-page-title-main">Carbohydrate (chondroitin 4) sulfotransferase 13</span>

Carbohydrate sulfotransferase 13 is a protein that is encoded in humans by the CHST13 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000182022 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030930 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi: 10.1093/dnares/5.1.31 . PMID   9628581.
  6. Verkoczy LK, Marsden PA, Berinstein NL (Oct 1998). "hBRAG, a novel B cell lineage cDNA encoding a type II transmembrane glycoprotein potentially involved in the regulation of recombination activating gene 1 (RAG1)". Eur J Immunol. 28 (9): 2839–53. doi:10.1002/(SICI)1521-4141(199809)28:09<2839::AID-IMMU2839>3.0.CO;2-6. PMID   9754571. S2CID   21656270.
  7. Ohtake S, Ito Y, Fukuta M, Habuchi O (Nov 2001). "Human N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase cDNA is related to human B cell recombination activating gene-associated gene". J Biol Chem. 276 (47): 43894–900. doi: 10.1074/jbc.M104922200 . PMID   11572857.
  8. "Entrez Gene: GALNAC4S-6ST B cell RAG associated protein".

Further reading