CHST15 | |||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | CHST15 , BRAG, GALNAC4S-6ST, carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15, carbohydrate sulfotransferase 15 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 608277 MGI: 1924840 HomoloGene: 8908 GeneCards: CHST15 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
|
Carbohydrate sulfotransferase 15 is an enzyme that in humans is encoded by the CHST15 gene. [5] [6] [7] [8] It belongs to the N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase enzyme class.
Carbohydrate sulfotransferase 2 is an enzyme that in humans is encoded by the CHST2 gene.
Carbohydrate sulfotransferase 4 is an enzyme that in humans is encoded by the CHST4 gene.
Neurocan core protein is a protein that in humans is encoded by the NCAN gene.
Carbohydrate sulfotransferase 1 is an enzyme that in humans is encoded by the CHST1 gene.
Galactose-3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the GAL3ST2 gene.
Carbohydrate sulfotransferase 11 is an enzyme that in humans is encoded by the CHST11 gene.
Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 is an enzyme that in humans is encoded by the HS3ST3A1 gene.
Carbohydrate sulfotransferase 12 is an enzyme that in humans is encoded by the CHST12 gene.
Heparan sulfate 2-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS2ST1 gene.
Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 is an enzyme that in humans is encoded by the HS3ST3B1 gene. Heparan sulfate biosynthetic enzymes are key components in generating myriad distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity ( HS3ST3A1). The Sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1 and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta.
Chondroitin sulfate proteoglycan 5 is a protein that in humans is encoded by the CSPG5 gene.
Chondroitin sulfate synthase 1 is an enzyme that in humans is encoded by the CHSY1 gene.
Carbohydrate sulfotransferase 7 is an enzyme that in humans is encoded by the CHST7 gene.
Galactose-3-O-sulfotransferase 3 is an enzyme that in humans is encoded by the GAL3ST3 gene.
Carbohydrate sulfotransferase 10 is an enzyme that in humans is encoded by the CHST10 gene.
Heparan sulfate glucosamine 3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the HS3ST2 gene.
Carbohydrate sulfotransferase 14 is an enzyme that in humans is encoded by the CHST14 gene.
Carbohydrate sulfotransferases are sulfotransferase enzymes that transfer sulfate to carbohydrate groups in glycoproteins and glycolipids. Carbohydrates are used by cells for a wide range of functions from structural purposes to extracellular communication. Carbohydrates are suitable for such a wide variety of functions due to the diversity in structure generated from monosaccharide composition, glycosidic linkage positions, chain branching, and covalent modification. Possible covalent modifications include acetylation, methylation, phosphorylation, and sulfation. Sulfation, performed by carbohydrate sulfotransferases, generates carbohydrate sulfate esters. These sulfate esters are only located extracellularly, whether through excretion into the extracellular matrix (ECM) or by presentation on the cell surface. As extracellular compounds, sulfated carbohydrates are mediators of intercellular communication, cellular adhesion, and ECM maintenance.
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase is an enzyme with systematic name 3'-phosphoadenylyl-sulfate:(dermatan)-4-O-sulfo-N-acetyl-D-galactosamine 6-O-sulfotransferase. This enzyme catalyses the following chemical reaction
Carbohydrate sulfotransferase 13 is a protein that is encoded in humans by the CHST13 gene.