GALNAC4S-6ST

CHST15
Identifiers
Aliases	CHST15 , BRAG, GALNAC4S-6ST, carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15, carbohydrate sulfotransferase 15
External IDs	OMIM: 608277; MGI: 1924840; HomoloGene: 8908; GeneCards: CHST15; OMA:CHST15 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q26.13 Start 124,007,668 bp [1] End 124,093,598 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F3 Start 131,837,509 bp [2] End 131,918,957 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood endothelial cell secondary oocyte tibia monocyte germinal epithelium periodontal fiber visceral pleura mucosa of paranasal sinus pericardium Top expressed in olfactory tubercle lumbar spinal ganglion granulocyte nucleus accumbens Region I of hippocampus proper fossa condyle spleen internal carotid artery left lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity 3'-phosphoadenosine 5'-phosphosulfate binding N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity Cellular component integral component of membrane Golgi membrane Golgi apparatus membrane Biological process chondroitin sulfate biosynthetic process hexose biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51363 77590 Ensembl ENSG00000182022 ENSMUSG00000030930 UniProt Q7LFX5 Q91XQ5 RefSeq (mRNA) NM_001270764 NM_001270765 NM_014863 NM_015892 NM_029935 NM_001360768 RefSeq (protein) NP_001257693 NP_001257694 NP_055678 NP_056976 NP_084211 NP_001347697 Location (UCSC) Chr 10: 124.01 – 124.09 Mb Chr 7: 131.84 – 131.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Carbohydrate sulfotransferase 15 is an enzyme that in humans is encoded by the CHST15 gene. ^{[5] [6] [7] [8]} It belongs to the N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase enzyme class.

References

1. GRCh38: Ensembl release 89: ENSG00000182022 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030930 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi: 10.1093/dnares/5.1.31 . PMID   9628581.
6. Verkoczy LK, Marsden PA, Berinstein NL (Oct 1998). "hBRAG, a novel B cell lineage cDNA encoding a type II transmembrane glycoprotein potentially involved in the regulation of recombination activating gene 1 (RAG1)". Eur J Immunol. 28 (9): 2839–53. doi: 10.1002/(SICI)1521-4141(199809)28:09<2839::AID-IMMU2839>3.0.CO;2-6 . PMID   9754571. S2CID   21656270.
7. Ohtake S, Ito Y, Fukuta M, Habuchi O (Nov 2001). "Human N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase cDNA is related to human B cell recombination activating gene-associated gene". J Biol Chem. 276 (47): 43894–900. doi: 10.1074/jbc.M104922200 . PMID   11572857.
8. "Entrez Gene: GALNAC4S-6ST B cell RAG associated protein".

Further reading

• Inoue H, Otsu K, Suzuki S, Nakanishi Y (1986). "Difference between N-acetylgalactosamine 4-sulfate 6-O-sulfotransferases from human serum and squid cartilage in specificity toward the terminal and interior portion of chondroitin sulfate". J. Biol. Chem. 261 (10): 4470–5. doi: 10.1016/S0021-9258(17)38523-X . PMID   3082866.
• Verkoczy LK, Guinn B, Berinstein NL (2000). "Characterization of the human B cell RAG-associated gene, hBRAG, as a B cell receptor signal-enhancing glycoprotein dimer that associates with phosphorylated proteins in resting B cells". J. Biol. Chem. 275 (28): 20967–79. doi: 10.1074/jbc.M001866200 . PMID   10749872.
• Yuki M, Yoshinaga K, Yamakawa H, et al. (2000). "Structure, expression and mutational analysis of the hBRAG gene on 10q in the frequently deleted region in human endometrial cancer". Oncol. Rep. 7 (6): 1339–42. doi:10.3892/or.7.6.1339. PMID   11032940.
• Sekiguchi T, Hirose E, Nakashima N, et al. (2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B." J. Biol. Chem. 276 (10): 7246–57. doi: 10.1074/jbc.M004389200 . PMID   11073942.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ohtake S, Kimata K, Habuchi O (2003). "A unique nonreducing terminal modification of chondroitin sulfate by N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase". J. Biol. Chem. 278 (40): 38443–52. doi: 10.1074/jbc.M306132200 . PMID   12874280.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID   15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Sawada T, Fujii S, Nakano H, et al. (2005). "Synthesis of sulfated phenyl 2-acetamido-2-deoxy-D-galactopyranosides. 4-O-Sulfated phenyl 2-acetamido-2-deoxy-beta-D-galactopyranoside is a competitive acceptor that decreases sulfation of chondroitin sulfate by N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase". Carbohydr. Res. 340 (12): 1983–96. doi:10.1016/j.carres.2005.06.010. PMID   16024005.