GALNT13

GALNT13
Identifiers
Aliases	GALNT13 , GalNAc-T13, polypeptide N-acetylgalactosaminyltransferase 13
External IDs	OMIM: 608369 MGI: 2139447 HomoloGene: 62167 GeneCards: GALNT13
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q23.3-q24.1 Start 153,871,922 bp [1] End 154,453,979 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 C1.1 Start 54,436,317 bp [2] End 55,118,309 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar cortex cerebellar hemisphere corpus callosum Achilles tendon secondary oocyte cerebellar vermis hypothalamus amygdala prefrontal cortex substantia nigra Top expressed in habenula cerebellar vermis olfactory tubercle nucleus accumbens substantia nigra inferior colliculus mammillary body temporal lobe superior frontal gyrus ventromedial nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function glycosyltransferase activity transferase activity metal ion binding carbohydrate binding polypeptide N-acetylgalactosaminyltransferase activity Cellular component integral component of membrane Golgi membrane Golgi apparatus membrane Biological process protein glycosylation O-glycan processing protein O-linked glycosylation protein O-linked glycosylation via serine protein O-linked glycosylation via threonine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114805 271786 Ensembl ENSG00000144278 ENSMUSG00000060988 UniProt Q8IUC8 Q8CF93 RefSeq (mRNA) NM_001301627 NM_052917 NM_173030 RefSeq (protein) NP_001288556 NP_443149 NP_001363321 NP_001363323 NP_001363327 NP_001363329 NP_001363330 NP_001363331 NP_001363332 NP_001363333 NP_001363334 NP_766618 Location (UCSC) Chr 2: 153.87 – 154.45 Mb Chr 2: 54.44 – 55.12 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Polypeptide N-acetylgalactosaminyltransferase 13 is an enzyme that in humans is encoded by the GALNT13 gene. ^{[5] [6] [7]}

The GALNT13 protein is a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAcT; EC 2.4.1.41) family, which initiate O-linked glycosylation of mucins (see MUC3A, MIM 158371) by the initial transfer of N-acetylgalactosamine (GalNAc) with an alpha-linkage to a serine or threonine residue.[supplied by OMIM] ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000144278 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060988 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Kikuno R, Ohara O (Sep 2001). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Res. 8 (4): 179–87. doi: 10.1093/dnares/8.4.179 . PMID   11572484.
6. Zhang Y, Iwasaki H, Wang H, Kudo T, Kalka TB, Hennet T, Kubota T, Cheng L, Inaba N, Gotoh M, Togayachi A, Guo J, Hisatomi H, Nakajima K, Nishihara S, Nakamura M, Marth JD, Narimatsu H (Dec 2002). "Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen". J Biol Chem. 278 (1): 573–84. doi: 10.1074/jbc.M203094200 . PMID   12407114.
7. "Entrez Gene: GALNT13 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)".

Further reading

• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID   9847074.
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID   11329013. S2CID   25064683.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.