GIMAP5

GIMAP5
Identifiers
Aliases	GIMAP5 , HIMAP3, IAN-5, IAN4, IAN4L1, IAN5, IMAP3, IROD, GTPase, IMAP family member 5, NCPH2
External IDs	OMIM: 608086; MGI: 1932723; GeneCards: GIMAP5; OMA:GIMAP5 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q36.1 Start 150,722,253 bp [1] End 150,750,033 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 B2.3 Start 48,741,398 bp [2] End 48,747,785 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung granulocyte upper lobe of left lung spleen lymph node apex of heart right lobe of thyroid gland left lobe of thyroid gland Achilles tendon gastric mucosa Top expressed in lymph node mesenteric lymph nodes spleen blood thymus subcutaneous adipose tissue duodenum right lung granulocyte submandibular gland More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 55340 83408 Ensembl ENSG00000196329 ENSMUSG00000039264 UniProt Q96F15 Q99MI6 RefSeq (mRNA) NM_018384 NM_031247 RefSeq (protein) NP_060854 NP_060854.2 NP_112537 Location (UCSC) Chr 7: 150.72 – 150.75 Mb Chr 6: 48.74 – 48.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

GTPase IMAP family member 5 is an enzyme that in humans is encoded by the GIMAP5 gene. ^[5]

This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000196329 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039264 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GIMAP5 GTPase, IMAP family member 5".

Further reading

• Dahéron L, Zenz T, Siracusa LD, et al. (2001). "Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activity". Nucleic Acids Res. 29 (6): 1308–16. doi:10.1093/nar/29.6.1308. PMC   29751 . PMID   11238997.
• Stamm O, Krücken J, Schmitt-Wrede HP, et al. (2002). "Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32-36". Gene. 282 (1–2): 159–67. doi:10.1016/S0378-1119(01)00837-X. PMID   11814688.
• Cambot M, Aresta S, Kahn-Perlès B, et al. (2002). "Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells". Blood. 99 (9): 3293–301. doi: 10.1182/blood.V99.9.3293 . PMID   11964296.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Sandal T, Aumo L, Hedin L, et al. (2004). "Irod/Ian5: an inhibitor of gamma-radiation- and okadaic acid-induced apoptosis". Mol. Biol. Cell. 14 (8): 3292–304. doi:10.1091/mbc.E02-10-0700. PMC   181568 . PMID   12925764.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Zenz T, Roessner A, Thomas A, et al. (2004). "hIan5: the human ortholog to the rat Ian4/Iddm1/lyp is a new member of the Ian family that is overexpressed in B-cell lymphoid malignancies". Genes Immun. 5 (2): 109–16. doi:10.1038/sj.gene.6364044. hdl: 11380/695502 . PMID   14724691. S2CID   750615.
• Krücken J, Schroetel RM, Müller IU, et al. (2005). "Comparative analysis of the human gimap gene cluster encoding a novel GTPase family". Gene. 341: 291–304. doi:10.1016/j.gene.2004.07.005. PMID   15474311.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Hellquist A, Zucchelli M, Kivinen K, et al. (2007). "The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus". J. Med. Genet. 44 (5): 314–21. doi:10.1136/jmg.2006.046185. PMC   2597989 . PMID   17220214.
• Dalberg U, Markholst H, Hornum L (2007). "Both Gimap5 and the diabetogenic BBDP allele of Gimap5 induce apoptosis in T cells". Int. Immunol. 19 (4): 447–53. doi: 10.1093/intimm/dxm009 . PMID   17369194.
• Shin JH, Janer M, McNeney B, et al. (2007). "IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5". Genes Immun. 8 (6): 503–12. doi: 10.1038/sj.gene.6364413 . PMID   17641683.