GLYCAM1

Last updated

GLYCAM1
Identifiers
Aliases GLYCAM1 , glycosylation dependent cell adhesion molecule 1 (pseudogene)
External IDs MGI: 95759; GeneCards: GLYCAM1; OMA:GLYCAM1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

644076

14663

Ensembl

ENSG00000257780

ENSMUSG00000022491

UniProt

n
a

Q02596

RefSeq (mRNA)

n/a

NM_001289587
NM_008134

RefSeq (protein)

n/a

NP_001276516
NP_032160

Location (UCSC) Chr 12: 54.61 – 54.61 Mb Chr 15: 103.47 – 103.47 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Glycosylation-dependent cell adhesion molecule-1 is a protein that is encoded by the GLYCAM1 gene. In humans, GLYCAM1 is a pseudogene while in many other mammals including mouse, it is a protein coding gene.

GLYCAM1 is a proteoglycan ligand expressed on cells of the high endothelial venules in lymphoid tissues. It is the ligand for the receptor L-selectin allowing for naive lymphocytes to exit the bloodstream into lymphoid tissues. [5] [6] GLYCAM1 binds to L-selectin by presenting one or more O-linked carbohydrates to the lectin domain of the leukocyte cell surface selectin.[ citation needed ] Data suggests that GLYCAM1 is a hormone-regulated milk protein that is part of the milk mucin complex. [7]

GlyCAM-1 is expressed exclusively on high endothelial venules. It is unclear how GlyCAM-1 is attached to the membrane as it lacks a transmembrane region. [5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000257780 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022491 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Imhof BA, Dunon D (1995). Leukocyte Migration and Adhesion . Advances in Immunology. Vol. 58. pp. 345–416. doi:10.1016/s0065-2776(08)60623-9. ISBN   978-0-12-022458-6. PMID   7537936.
  6. ↑ Brustein M, Kraal G, Mebius RE, Watson SR (November 1992). "Identification of a soluble form of a ligand for the lymphocyte homing receptor". The Journal of Experimental Medicine. 176 (5): 1415–1419. doi:10.1084/jem.176.5.1415. PMC   2119429 . PMID   1383387.
  7. ↑ Dowbenko D, Kikuta A, Fennie C, Gillett N, Lasky LA (August 1993). "Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) mucin is expressed by lactating mammary gland epithelial cells and is present in milk". The Journal of Clinical Investigation. 92 (2): 952–960. doi:10.1172/JCI116671. PMC   294935 . PMID   8349827.
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