GLYCAM1

Last updated
glycosylation dependent cell adhesion molecule-1
Identifiers
SymbolGLYCAM1
NCBI gene 644076
HGNC 18023
RefSeq XM_927461
UniProt Q8IVK1
Other data
Locus Chr. 12 q13.2
Search for
Structures Swiss-model
Domains InterPro

Glycosylation-dependent cell adhesion molecule-1 (GLYCAM1) is a proteoglycan ligand expressed on cells of the high endothelial venules in lymphoid tissues. It is the ligand for the receptor L-selectin allowing for naive lymphocytes to exit the bloodstream into lymphoid tissues. [1] [2] GLYCAM1 binds to L-selectin by presenting one or more O-linked carbohydrates to the lectin domain of the leukocyte cell surface selectin.[ citation needed ] Data suggests that GLYCAM1 is a hormone-regulated milk protein that is part of the milk mucin complex. [3]

GlyCAM-1 is expressed exclusively on high endothelial venules. It is unclear how GlyCAM-1 is attached to the membrane as it lacks a transmembrane region. [1]

References

  1. 1 2 Imhof, Beat A.; Dunon, Dominique (1995). Leukocyte Migration and Adhesion . Advances in Immunology. Vol. 58. pp. 345–416. doi:10.1016/s0065-2776(08)60623-9. ISBN   9780120224586. PMID   7537936.
  2. ↑ Brustein, M.; Kraal, G.; Mebius, R. E.; Watson, S. R. (1 November 1992). "Identification of a soluble form of a ligand for the lymphocyte homing receptor". The Journal of Experimental Medicine. 176 (5): 1415–1419. doi:10.1084/jem.176.5.1415. PMC   2119429 . PMID   1383387.
  3. ↑ Dowbenko, D; Kikuta, A; Fennie, C; Gillett, N; Lasky, L A (1 August 1993). "Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) mucin is expressed by lactating mammary gland epithelial cells and is present in milk". Journal of Clinical Investigation. 92 (2): 952–960. doi:10.1172/JCI116671. PMC   294935 . PMID   8349827.
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