GSDMB | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | GSDMB , GSDML, PRO2521, PP4052, gasdermin B, GSDMB-1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 611221 HomoloGene: 88856 GeneCards: GSDMB | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Gasdermin B is a protein that in humans is encoded by the GSDMB gene. [3]
This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding.
Frizzled-8(Fz-8) is a protein that in humans is encoded by the FZD8 gene.
Frizzled-10(Fz-10) is a protein that in humans is encoded by the FZD10 gene. Fz-10 has also been designated as CD350.
Frizzled-4(Fz-4) is a protein that in humans is encoded by the FZD4 gene. Fz-4 has also been designated as CD344.
Homeobox protein Hox-C4 is a protein that in humans is encoded by the HOXC4 gene.
Serine/threonine-protein kinase SIK2 is an enzyme that in humans is encoded by the SIK2 gene.
Transcription factor RFX4 is a protein that in humans is encoded by the RFX4 gene.
Transcription factor RFX3 is a protein that in humans is encoded by the RFX3 gene.
Protein Wnt-2b is a protein that in humans is encoded by the WNT2B gene.
UBX domain-containing protein 11 is a protein that in humans is encoded by the UBXN11 gene.
Forkhead box protein P4 is a protein that in humans is encoded by the FOXP4 gene.
Tyrosine-protein kinase-like 7 also known as colon carcinoma kinase 4 (CCK4) is a receptor tyrosine kinase that in humans is encoded by the PTK7 gene.
Protein Wnt-5b is a protein that in humans is encoded by the WNT5B gene.
Syntaxin-binding protein 5 is a protein that in humans is encoded by the STXBP5 gene. It is also known as tomosyn, after 友, "friend" in Japanese, for its role as a binding protein.
WD repeat-containing protein 11 (WDR11) also known as bromodomain and WD repeat-containing protein 2 (BRWD2) is a protein that in humans is encoded by the WDR11 gene.
Protein Wnt-8b is a protein that in humans is encoded by the WNT8B gene.
PR domain zinc finger protein 9 is a protein that in humans is encoded by the PRDM9 gene. PRDM9 is responsible for positioning recombination hotspots during meiosis by binding a DNA sequence motif encoded in its zinc finger domain. PRDM9 is the only speciation gene found so far in mammals, and is one of the fastest evolving genes in the genome.
Hes family bHLH transcription factor 3 is a protein that in humans is encoded by the HES3 gene.
Gasdermin A is a protein that in humans is encoded by the GSDMA gene.
Prickle planar cell polarity protein 1 is a protein that in humans is encoded by the PRICKLE1 gene.
StAR related lipid transfer domain containing 3(STARD3) is a protein that in humans is encoded by the STARD3 gene. STARD3 also known as metastatic lymph node 64 protein (MLN64) is a late endosomal integral membrane protein involved in cholesterol transport. STARD3 creates membrane contact sites between the endoplasmic reticulum (ER) and late endosomes where it moves cholesterol.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.