GSG2

HASPIN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VUW, 2WB8, 3DLZ, 3E7V, 3F2N, 3FMD, 3IQ7, 4OUC, 4QTC, 5HTC, 5HTB
Identifiers
Aliases	HASPIN , GSG2, germ cell associated 2, haspin, histone H3 associated protein kinase
External IDs	OMIM: 609240 MGI: 1194498 HomoloGene: 49236 GeneCards: HASPIN
Gene location (Human)
Chr.	Chromosome 17 (human)
End	3,726,699 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	73,029,120 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; secondary oocyte; ; tibialis anterior muscle; ; ganglionic eminence; ; bone marrow cells; ; sperm; ; stromal cell of endometrium; ; appendix; ; lymph node; ; rectum;
	Top expressed in
	spermatid; ; seminiferous tubule; ; spermatocyte; ; secondary oocyte; ; primitive streak; ; abdominal wall; ; otic placode; ; morula; ; thymus; ; yolk sac;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity ; nucleotide binding ; kinase activity ; protein serine/threonine kinase activity ; protein binding ; histone kinase activity (H3-T3 specific) ; ATP binding ; protein kinase activity ;
Cellular component	cytoplasm ; centrosome ; chromosome ; cytoskeleton ; nucleus ; spindle ;
Biological process	intracellular signal transduction ; phosphorylation ; mitotic sister chromatid cohesion ; protein localization to chromosome, centromeric region ; cell cycle ; protein phosphorylation ; chromatin organization ; mitotic cell cycle ;
	Sources:Amigo / QuickGO
Orthologs
	83903
	14841
	ENSG00000177602
	ENSMUSG00000050107
	Q8TF76
	Q9Z0R0
	NM_031965
	NM_010353
	NP_114171
	NP_034483
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Serine/threonine-protein kinase haspin is an enzyme that in humans is encoded by the GSG2 gene.^[5]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000177602 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050107 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: GSG2 germ cell associated 2 (haspin)".

Dai J, Sullivan BA, Higgins JM (2007). "Regulation of mitotic chromosome cohesion by Haspin and Aurora B." Dev. Cell. 11 (5): 741–50. doi: 10.1016/j.devcel.2006.09.018 . PMID 17084365.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC 1459365 . PMID 16565220.
Dai J, Sultan S, Taylor SS, Higgins JM (2005). "The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment". Genes Dev. 19 (4): 472–88. doi:10.1101/gad.1267105. PMC 548948 . PMID 15681610.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Higgins JM (2001). "The Haspin gene: location in an intron of the integrin alphaE gene, associated transcription of an integrin alphaE-derived RNA and expression in diploid as well as haploid cells". Gene. 267 (1): 55–69. doi:10.1016/S0378-1119(01)00387-0. PMID 11311556.
Tanaka H, Iguchi N, Nakamura Y, et al. (2001). "Cloning and characterization of human haspin gene encoding haploid germ cell-specific nuclear protein kinase". Mol. Hum. Reprod. 7 (3): 211–8. doi: 10.1093/molehr/7.3.211 . PMID 11228240.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000177602 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050107 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GSG2 germ cell associated 2 (haspin)".

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GSG2

Related Research Articles

References

Further reading