GSTO2

Last updated
GSTO2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GSTO2 , GSTO 2-2, bA127L20.1, glutathione S-transferase omega 2
External IDs OMIM: 612314 MGI: 1915464 HomoloGene: 57057 GeneCards: GSTO2
EC number 1.8.5.1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001191013
NM_001191014
NM_001191015
NM_183239

NM_026619
NM_030051

RefSeq (protein)

NP_001177942
NP_001177943
NP_001177944
NP_899062

NP_080895
NP_084327

Location (UCSC) Chr 10: 104.27 – 104.3 Mb Chr 19: 47.85 – 47.87 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Glutathione S-transferase omega-2 is an enzyme that in humans is encoded by the GSTO2 gene. [5] [6]

Related Research Articles

Glutathione <i>S</i>-transferase Family of enzymes

Glutathione S-transferases (GSTs), previously known as ligandins, are a family of eukaryotic and prokaryotic phase II metabolic isozymes best known for their ability to catalyze the conjugation of the reduced form of glutathione (GSH) to xenobiotic substrates for the purpose of detoxification. The GST family consists of three superfamilies: the cytosolic, mitochondrial, and microsomal—also known as MAPEG—proteins. Members of the GST superfamily are extremely diverse in amino acid sequence, and a large fraction of the sequences deposited in public databases are of unknown function. The Enzyme Function Initiative (EFI) is using GSTs as a model superfamily to identify new GST functions.

<span class="mw-page-title-main">Glutathione S-transferase Mu 1</span> Protein-coding gene in the species Homo sapiens

Glutathione S-transferase Mu 1 is a human glutathione S-transferase.

<span class="mw-page-title-main">GSTP1</span> Protein-coding gene in the species Homo sapiens

Glutathione S-transferase P is an enzyme that in humans is encoded by the GSTP1 gene.

<span class="mw-page-title-main">GPX1</span> Protein-coding gene in the species Homo sapiens

Glutathione peroxidase 1, also known as GPx1, is an enzyme that in humans is encoded by the GPX1 gene on chromosome 3. This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans.

<span class="mw-page-title-main">Glutathione S-transferase A1</span> Protein-coding gene in the species Homo sapiens

Glutathione S-transferase A1 is an enzyme that in humans is encoded by the GSTA1 gene.

<span class="mw-page-title-main">GSTA2</span> Protein-coding gene in the species Homo sapiens

Glutathione S-transferase A2 is an enzyme that in humans is encoded by the GSTA2 gene.

<span class="mw-page-title-main">GSTM2</span> Protein-coding gene in the species Homo sapiens

Glutathione S-transferase Mu 2 is an enzyme that in humans is encoded by the GSTM2 gene.

<span class="mw-page-title-main">GSTM3</span> Protein-coding gene in the species Homo sapiens

Glutathione S-transferase M3 (brain), also known as GSTM2, is an enzyme which in humans is encoded by the GSTM99 gene.

<span class="mw-page-title-main">GSTA4</span> Protein-coding gene in the species Homo sapiens

Glutathione S-transferase A4, also known as GSTA4, is an enzyme which in humans is encoded by the GSTA4 gene.

<span class="mw-page-title-main">GSTT2</span> Protein-coding gene in the species Homo sapiens

Glutathione S-transferase theta-2 is an enzyme that in humans is encoded by the GSTT2 gene.

<span class="mw-page-title-main">GSTZ1</span> Protein-coding gene in the species Homo sapiens

Glutathione S-transferase Zeta 1 is an enzyme that in humans is encoded by the GSTZ1 gene on chromosome 14.

<span class="mw-page-title-main">GSTM4</span> Protein-coding gene in the species Homo sapiens

Glutathione S-transferase Mu 4 is an enzyme that in humans is encoded by the GSTM4 gene.

<span class="mw-page-title-main">Microsomal glutathione S-transferase 1</span> Protein-coding gene in the species Homo sapiens

Microsomal glutathione S-transferase 1 is an enzyme that in humans is encoded by the MGST1 gene.

<span class="mw-page-title-main">GSTO1</span> Mammalian protein found in Homo sapiens

Glutathione S-transferase omega-1 is an enzyme that in humans is encoded by the GSTO1 gene.

<span class="mw-page-title-main">WFDC2</span> Protein-coding gene in the species Homo sapiens

WAP four-disulfide core domain protein 2 - also known as Human Epididymis Protein 4 (HE4) - is a protein that in humans is encoded by the WFDC2 gene.

<span class="mw-page-title-main">GSTK1</span> Protein-coding gene in the species Homo sapiens

Glutathione S-transferase kappa 1 (GSTK1) is an enzyme that in humans is encoded by the GSTK1 gene which is located on chromosome seven. It belongs to the superfamily of enzymes known as glutathione S-transferase (GST), which are mainly known for cellular detoxification. The GSTK1 gene consists of eight exons and seven introns and although it is a member of the GST family, its structure has been found to be similar to bacterial HCCA (2-hydroxychromene-2-carboxylate) isomerases and bacterial disulphide-bond-forming DsbA oxidoreductase. This similarity has later allowed the enzyme GSTK1 to be renamed to DsbA-L. Research has also suggested that several variations of the GSTK1 gene can be responsible for metabolic diseases and certain types of cancer.

<span class="mw-page-title-main">GSTA3</span> Protein-coding gene in the species Homo sapiens

Glutathione S-transferase A3 is an enzyme that in humans is encoded by the GSTA3 gene.

<span class="mw-page-title-main">EPHX1</span> Protein-coding gene in the species Homo sapiens

Epoxide hydrolase 1 is an enzyme encoded by the EPHX1 gene in humans.

<span class="mw-page-title-main">GPX3</span> Enzyme in humans

Glutathione peroxidase 3 (GPx-3), also known as plasma glutathione peroxidase (GPx-P) or extracellular glutathione peroxidase is an enzyme that in humans is encoded by the GPX3 gene.

<span class="mw-page-title-main">Deleted in lung and esophageal cancer 1</span> Protein-coding gene in the species Homo sapiens

Deleted in lung and esophageal cancer 1 is a protein that in humans is encoded by the DLEC1 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000065621 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025069 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Whitbread AK, Tetlow N, Eyre HJ, Sutherland GR, Board PG (Mar 2003). "Characterization of the human Omega class glutathione transferase genes and associated polymorphisms". Pharmacogenetics. 13 (3): 131–44. doi:10.1097/00008571-200303000-00003. PMID   12618591.
  6. "Entrez Gene: GSTO2 glutathione S-transferase omega 2".

Further reading