GSTO2

GSTO2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3Q18, 3Q19, 3QAG
Identifiers
Aliases	GSTO2 , GSTO 2-2, bA127L20.1, glutathione S-transferase omega 2
External IDs	OMIM: 612314; MGI: 1915464; HomoloGene: 57057; GeneCards: GSTO2; OMA:GSTO2 - orthologs
EC number	1.8.5.1
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q25.1 Start 104,268,873 bp [1] End 104,304,950 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 D1 Start 47,853,973 bp [2] End 47,874,763 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas skin of arm islet of Langerhans skin of abdomen right testis right uterine tube left testis skin of leg anterior pituitary pancreatic ductal cell Top expressed in spermatid spermatocyte seminiferous tubule hair morula embryo embryo thyroid gland brown adipose tissue transitional epithelium of urinary bladder More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity oxidoreductase activity methylarsonate reductase activity protein binding glutathione dehydrogenase (ascorbate) activity identical protein binding glutathione transferase activity Cellular component cytosol extracellular exosome cytoplasm Biological process metabolism cellular response to arsenic-containing substance glutathione derivative biosynthetic process L-ascorbic acid metabolic process xenobiotic metabolic process cellular oxidant detoxification glutathione metabolic process toxin catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 119391 68214 Ensembl ENSG00000065621 ENSMUSG00000025069 UniProt Q9H4Y5 Q8K2Q2 RefSeq (mRNA) NM_001191013 NM_001191014 NM_001191015 NM_183239 NM_026619 NM_030051 RefSeq (protein) NP_001177942 NP_001177943 NP_001177944 NP_899062 NP_080895 NP_084327 Location (UCSC) Chr 10: 104.27 – 104.3 Mb Chr 19: 47.85 – 47.87 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Glutathione S-transferase omega-2 is an enzyme that in humans is encoded by the GSTO2 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000065621 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025069 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Whitbread AK, Tetlow N, Eyre HJ, Sutherland GR, Board PG (Mar 2003). "Characterization of the human Omega class glutathione transferase genes and associated polymorphisms". Pharmacogenetics. 13 (3): 131–44. doi:10.1097/00008571-200303000-00003. PMID   12618591.
6. "Entrez Gene: GSTO2 glutathione S-transferase omega 2".

Further reading

• White DL, Li D, Nurgalieva Z, El-Serag HB (Feb 2008). "Genetic variants of glutathione S-transferase as possible risk factors for hepatocellular carcinoma: a HuGE systematic review and meta-analysis". American Journal of Epidemiology. 167 (4): 377–89. doi: 10.1093/aje/kwm315 . PMID   18065725.
• Calarco JA, Xing Y, Cáceres M, Calarco JP, Xiao X, Pan Q, Lee C, Preuss TM, Blencowe BJ (Nov 2007). "Global analysis of alternative splicing differences between humans and chimpanzees". Genes & Development. 21 (22): 2963–75. doi:10.1101/gad.1606907. PMC   2049197 . PMID   17978102.
• Leite JL, Morari EC, Granja F, Campos GM, Guilhen AC, Ward LS (Mar 2007). "Influence of the glutathione s-transferase gene polymorphisms on the susceptibility to basal cell skin carcinoma". Revista Médica de Chile . 135 (3): 301–6. doi: 10.4067/s0034-98872007000300004 . PMID   17505575.
• Wahner AD, Glatt CE, Bronstein JM, Ritz B (Feb 2007). "Glutathione S-transferase mu, omega, pi, and theta class variants and smoking in Parkinson's disease". Neuroscience Letters. 413 (3): 274–8. doi:10.1016/j.neulet.2006.11.053. PMC   1864949 . PMID   17194543.
• Morari EC, Lima AB, Bufalo NE, Leite JL, Granja F, Ward LS (Aug 2006). "Role of glutathione-S-transferase and codon 72 of P53 genotypes in epithelial ovarian cancer patients". Journal of Cancer Research and Clinical Oncology. 132 (8): 521–8. doi:10.1007/s00432-006-0099-3. PMID   16788846. S2CID   12993417.
• Pongstaporn W, Rochanawutanon M, Wilailak S, Linasamita V, Weerakiat S, Petmitr S (Mar 2006). "Genetic alterations in chromosome 10q24.3 and glutathione S-transferase omega 2 gene polymorphism in ovarian cancer". Journal of Experimental & Clinical Cancer Research. 25 (1): 107–14. PMID   16761626.
• Marahatta SB, Punyarit P, Bhudisawasdi V, Paupairoj A, Wongkham S, Petmitr S (May 2006). "Polymorphism of glutathione S-transferase omega gene and risk of cancer". Cancer Letters. 236 (2): 276–81. doi:10.1016/j.canlet.2005.05.020. PMID   15992993.
• Wang L, Xu J, Ji C, Gu S, Lv Y, Li S, Xu Y, Xie Y, Mao Y (Jul 2005). "Cloning, expression and characterization of human glutathione S-transferase Omega 2". International Journal of Molecular Medicine. 16 (1): 19–27. doi:10.3892/ijmm.16.1.19. PMID   15942673.
• Ozturk A, Desai PP, Minster RL, Dekosky ST, Kamboh MI (2005). "Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease". Neurobiology of Aging. 26 (8): 1161–5. doi: 10.1016/j.neurobiolaging.2004.11.001 . PMID   15917099. S2CID   10878355.
• Whitbread AK, Mellick GD, Silburn PA, Le Couteur DG, Board PG (May 2004). "Glutathione transferase Omega class polymorphisms in Parkinson disease". Neurology. 62 (10): 1910–1. doi:10.1212/01.wnl.0000125282.09308.b1. PMID   15159516. S2CID   46505059.
• Arning L, Jagiello P, Wieczorek S, Saft C, Andrich J, Epplen JT (Mar 2004). "Glutathione S-Transferase Omega 1 variation does not influence age at onset of Huntington's disease". BMC Medical Genetics. 5: 7. doi: 10.1186/1471-2350-5-7 . PMC   394327 . PMID   15040808.