GSTT2

Last updated
GSTT2
Protein GSTT2 PDB 1ljr.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GSTT2 , GSTT2B, glutathione S-transferase theta 2 (gene/pseudogene)
External IDs OMIM: 600437 MGI: 106188 HomoloGene: 37358 GeneCards: GSTT2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000854
NM_001302670

NM_010361

RefSeq (protein)

NP_000845
NP_001289599

NP_034491

Location (UCSC) Chr 22: 23.98 – 23.98 Mb Chr 10: 75.67 – 75.67 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Glutathione S-transferase theta-2 is an enzyme that in humans is encoded by the GSTT2 gene. [5] [6] [7]

Glutathione S-transferase (GSTs) theta 2 (GSTT2) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: Alpha, Mu, Pi, Theta, and Zeta. The theta class members GSTT1 and GSTT2 share 55% amino acid sequence identity and both are thought to have an important role in human carcinogenesis. The theta genes have a similar structure, being composed of five exons with identical exon/intron boundaries. [7]

Related Research Articles

<span class="mw-page-title-main">Glutathione S-transferase Mu 1</span> Protein-coding gene in the species Homo sapiens

Glutathione S-transferase Mu 1 is a human glutathione S-transferase.

<span class="mw-page-title-main">Glutathione S-transferase A1</span> Protein-coding gene in the species Homo sapiens

Glutathione S-transferase A1 is an enzyme that in humans is encoded by the GSTA1 gene.

<span class="mw-page-title-main">GSTA2</span> Protein-coding gene in the species Homo sapiens

Glutathione S-transferase A2 is an enzyme that in humans is encoded by the GSTA2 gene.

<span class="mw-page-title-main">GSTM2</span> Protein-coding gene in the species Homo sapiens

Glutathione S-transferase Mu 2 is an enzyme that in humans is encoded by the GSTM2 gene.

<span class="mw-page-title-main">GSTM3</span> Protein-coding gene in the species Homo sapiens

Glutathione S-transferase M3 (brain), also known as GSTM2, is an enzyme which in humans is encoded by the GSTM99 gene.

<span class="mw-page-title-main">GSTA4</span> Protein-coding gene in the species Homo sapiens

Glutathione S-transferase A4, also known as GSTA4, is an enzyme which in humans is encoded by the GSTA4 gene.

<span class="mw-page-title-main">GSTM4</span> Protein-coding gene in the species Homo sapiens

Glutathione S-transferase Mu 4 is an enzyme that in humans is encoded by the GSTM4 gene.

<span class="mw-page-title-main">Microsomal glutathione S-transferase 1</span> Protein-coding gene in the species Homo sapiens

Microsomal glutathione S-transferase 1 is an enzyme that in humans is encoded by the MGST1 gene.

<span class="mw-page-title-main">GSTO1</span> Mammalian protein found in Homo sapiens

Glutathione S-transferase omega-1 is an enzyme that in humans is encoded by the GSTO1 gene.

<span class="mw-page-title-main">PGDS</span> Protein-coding gene in the species Homo sapiens

PGDS protein is a protein that in humans is encoded by the HPGDS gene.

<span class="mw-page-title-main">PMM1</span> Protein-coding gene in the species Homo sapiens

Phosphomannomutase 1 is an enzyme that in humans is encoded by the PMM1 gene.

<span class="mw-page-title-main">DDT (gene)</span> Protein-coding gene in the species Homo sapiens

D-dopachrome decarboxylase is an enzyme that in humans is encoded by the DDT gene.

<span class="mw-page-title-main">GSTK1</span> Protein-coding gene in the species Homo sapiens

Glutathione S-transferase kappa 1 (GSTK1) is an enzyme that in humans is encoded by the GSTK1 gene which is located on chromosome seven. It belongs to the superfamily of enzymes known as glutathione S-transferase (GST), which are mainly known for cellular detoxification. The GSTK1 gene consists of eight exons and seven introns and although it is a member of the GST family, its structure has been found to be similar to bacterial HCCA (2-hydroxychromene-2-carboxylate) isomerases and bacterial disulphide-bond-forming DsbA oxidoreductase. This similarity has later allowed the enzyme GSTK1 to be renamed to DsbA-L. Research has also suggested that several variations of the GSTK1 gene can be responsible for metabolic diseases and certain types of cancer.

<span class="mw-page-title-main">60S ribosomal protein L19</span> Protein found in humans

60S ribosomal protein L19 is a protein that in humans is encoded by the RPL19 gene.

<span class="mw-page-title-main">HIC2</span> Protein-coding gene in the species Homo sapiens

Hypermethylated in cancer 2 protein is a protein that in humans is encoded by the HIC2 gene.

<span class="mw-page-title-main">MGAT1</span> Protein-coding gene in the species Homo sapiens

Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT1 gene.

<span class="mw-page-title-main">B4GALNT1</span> Protein-coding gene in humans

Beta-1,4 N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the B4GALNT1 gene.

<span class="mw-page-title-main">GSTA3</span> Protein-coding gene in the species Homo sapiens

Glutathione S-transferase A3 is an enzyme that in humans is encoded by the GSTA3 gene.

<span class="mw-page-title-main">TGM4</span> Protein-coding gene in the species Homo sapiens

Protein-glutamine gamma-glutamyltransferase 4 is an enzyme that in humans is encoded by the TGM4 gene.

<span class="mw-page-title-main">GPX5</span> Protein-coding gene in the species Homo sapiens

Glutathione peroxidase 5 (GPx-5), also known as epididymal secretory glutathione peroxidase is an enzyme that in humans is encoded by the GPX5 gene.

References

  1. 1 2 3 ENSG00000277897 GRCh38: Ensembl release 89: ENSG00000099984, ENSG00000277897 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033318 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tan KL, Webb GC, Baker RT, Board PG (Jul 1995). "Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22". Genomics. 25 (2): 381–7. doi:10.1016/0888-7543(95)80037-M. PMID   7789971.
  6. Coggan M, Whitbread L, Whittington A, Board P (Nov 1998). "Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex". Biochem J. 334 (3): 617–23. doi:10.1042/bj3340617. PMC   1219731 . PMID   9729470.
  7. 1 2 "Entrez Gene: GSTT2 glutathione S-transferase theta 2".

Further reading