GSTT2

GSTT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4MPF
Identifiers
Aliases	GSTT2 , GSTT2B, glutathione S-transferase theta 2 (gene/pseudogene)
External IDs	OMIM: 600437; MGI: 106188; HomoloGene: 37358; GeneCards: GSTT2; OMA:GSTT2 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q11.23 Start 23,980,058 bp [1] End 23,983,915 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 C1|10 38.58 cM Start 75,666,948 bp [2] End 75,673,258 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle stromal cell of endometrium superior frontal gyrus prefrontal cortex fundus right adrenal cortex apex of heart primary visual cortex left adrenal gland ascending aorta Top expressed in right kidney human kidney proximal tubule duodenum left lobe of liver spermatocyte yolk sac cervix embryo transitional epithelium of urinary bladder More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity glutathione transferase activity Cellular component extracellular exosome cytoplasm Biological process glutathione metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2953 14872 Ensembl ENSG00000099984 ENSG00000277897 ENSMUSG00000033318 UniProt P0CG29 Q61133 RefSeq (mRNA) NM_000854 NM_001302670 NM_010361 RefSeq (protein) NP_000845 NP_001289599 NP_034491 Location (UCSC) Chr 22: 23.98 – 23.98 Mb Chr 10: 75.67 – 75.67 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Glutathione S-transferase theta-2 is an enzyme that in humans is encoded by the GSTT2 gene. ^{[5] [6] [7]}

Glutathione S-transferase (GSTs) theta 2 (GSTT2) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: Alpha, Mu, Pi, Theta, and Zeta. The theta class members GSTT1 and GSTT2 share 55% amino acid sequence identity and both are thought to have an important role in human carcinogenesis. The theta genes have a similar structure, being composed of five exons with identical exon/intron boundaries. ^[7]

References

1. ENSG00000277897 GRCh38: Ensembl release 89: ENSG00000099984, ENSG00000277897 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033318 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tan KL, Webb GC, Baker RT, Board PG (Jul 1995). "Molecular cloning of a cDNA and chromosomal localization of a human theta-class glutathione S-transferase gene (GSTT2) to chromosome 22". Genomics. 25 (2): 381–7. doi:10.1016/0888-7543(95)80037-M. PMID   7789971.
6. Coggan M, Whitbread L, Whittington A, Board P (Nov 1998). "Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex". Biochem J. 334 (3): 617–23. doi:10.1042/bj3340617. PMC   1219731 . PMID   9729470.
7. "Entrez Gene: GSTT2 glutathione S-transferase theta 2".

Further reading

• Hussey AJ, Hayes JD (1992). "Characterization of a human class-Theta glutathione S-transferase with activity towards 1-menaphthyl sulphate". Biochem. J. 286 (3): 929–35. doi:10.1042/bj2860929. PMC   1132992 . PMID   1417752.
• Whittington AT, Webb GC, Baker RT, Board PG (1996). "Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1". Genomics. 33 (1): 105–11. doi:10.1006/geno.1996.0165. PMID   8617493.
• Webb G, Vaska V, Coggan M, Board P (1996). "Chromosomal localization of the gene for the human theta class glutathione transferase (GSTT1)". Genomics. 33 (1): 121–3. doi:10.1006/geno.1996.0167. PMID   8617495.
• Mainwaring GW, Williams SM, Foster JR, et al. (1996). "The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human". Biochem. J. 318 (1): 297–303. doi:10.1042/bj3180297. PMC   1217621 . PMID   8761485.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Chelvanayagam G, Wilce MC, Parker MW, et al. (1997). "Homology model for the human GSTT2 Theta class glutathione transferase". Proteins. 27 (1): 118–30. doi:10.1002/(SICI)1097-0134(199701)27:1<118::AID-PROT12>3.0.CO;2-Q. PMID   9037717. S2CID   35684018.
• Rossjohn J, McKinstry WJ, Oakley AJ, et al. (1998). "Human theta class glutathione transferase: the crystal structure reveals a sulfate-binding pocket within a buried active site". Structure. 6 (3): 309–22. doi: 10.1016/S0969-2126(98)00034-3 . PMID   9551553.
• de Bruin WC, Wagenmans MJ, Board PG, Peters WH (1999). "Expression of glutathione S-transferase theta class isoenzymes in human colorectal and gastric cancers". Carcinogenesis. 20 (8): 1453–7. doi:10.1093/carcin/20.8.1453. PMID   10426791.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• de Bruin WC, Wagenmans MJ, Peters WH (2000). "Expression of glutathione S-transferase alpha, P1-1 and T1-1 in the human gastrointestinal tract". Jpn. J. Cancer Res. 91 (3): 310–6. doi:10.1111/j.1349-7006.2000.tb00946.x. PMC   5926361 . PMID   10760690.
• Sprenger R, Schlagenhaufer R, Kerb R, et al. (2001). "Characterization of the glutathione S-transferase GSTT1 deletion: discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotype-phenotype correlation". Pharmacogenetics. 10 (6): 557–65. doi:10.1097/00008571-200008000-00009. PMID   10975610.
• Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–51. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID   11181995.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• De Maria F, Pedersen JZ, Caccuri AM, et al. (2004). "The specific interaction of dinitrosyl-diglutathionyl-iron complex, a natural NO carrier, with the glutathione transferase superfamily: suggestion for an evolutionary pressure in the direction of the storage of nitric oxide". J. Biol. Chem. 278 (43): 42283–93. doi: 10.1074/jbc.M305568200 . PMID   12871945.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC   545604 . PMID   15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Jang SG, Kim IJ, Kang HC, et al. (2007). "GSTT2 promoter polymorphisms and colorectal cancer risk". BMC Cancer. 7: 16. doi: 10.1186/1471-2407-7-16 . PMC   1793996 . PMID   17250773.