GTSE1

GTSE1
Identifiers
Aliases	GTSE1 , B99, G2 and S-phase expressed 1
External IDs	OMIM: 607477 MGI: 1352755 HomoloGene: 8489 GeneCards: GTSE1
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q13.31 Start 46,296,870 bp [1] End 46,330,810 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15 E2|15 40.42 cM Start 85,743,946 bp [2] End 85,760,774 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cancellous bone pancreatic ductal cell periodontal fiber sperm cardia endothelial cell pylorus nipple vena cava secondary oocyte Top expressed in secondary oocyte yolk sac morula thymus primitive streak spermatocyte maxillary prominence ganglionic eminence abdominal wall lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding molecular function Cellular component cytoplasm cytoplasmic microtubule microtubule cytoskeleton membrane cytosol nucleoplasm Biological process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest microtubule-based process regulation of cell cycle G2/M phase transition negative regulation of microtubule binding positive regulation of protein localization to nucleus proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of protein export from nucleus protein stabilization positive regulation of cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51512 29870 Ensembl ENSG00000075218 ENSMUSG00000022385 UniProt Q9NYZ3 Q8R080 RefSeq (mRNA) NM_016426 NM_001168672 NM_013882 RefSeq (protein) NP_057510 NP_001162143 NP_038910 Location (UCSC) Chr 22: 46.3 – 46.33 Mb Chr 15: 85.74 – 85.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

G2 and S phase-expressed protein 1 is an enzyme that in humans is encoded by the GTSE1 gene. ^{[5] [6] [7] [8]}

The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000075218 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022385 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Monte M, Collavin L, Lazarevic D, Utrera R, Dragani TA, Schneider C (Oct 2000). "Cloning, chromosome mapping and functional characterization of a human homologue of murine gtse-1 (B99) gene". Gene. 254 (1–2): 229–36. doi:10.1016/S0378-1119(00)00260-2. PMID   10974554.
6. Collavin L, Monte M, Verardo R, Pfleger C, Schneider C (Oct 2000). "Cell-cycle regulation of the p53-inducible gene B99". FEBS Lett. 481 (1): 57–62. doi: 10.1016/S0014-5793(00)01969-4 . PMID   10984615.
7. Monte M, Benetti R, Buscemi G, Sandy P, Del Sal G, Schneider C (Aug 2003). "The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function". J Biol Chem. 278 (32): 30356–64. doi: 10.1074/jbc.M302902200 . PMID   12750368.
8. "Entrez Gene: GTSE1 G-2 and S-phase expressed 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Monte M, Benetti R, Collavin L, et al. (2004). "hGTSE-1 expression stimulates cytoplasmic localization of p53". J. Biol. Chem. 279 (12): 11744–52. doi: 10.1074/jbc.M311123200 . PMID   14707141.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID   15790807. S2CID   13047538.
• Kapranov P, Drenkow J, Cheng J, et al. (2005). "Examples of the complex architecture of the human transcriptome revealed by RACE and high-density tiling arrays". Genome Res. 15 (7): 987–97. doi:10.1101/gr.3455305. PMC   1172043 . PMID   15998911.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.