GYLTL1B

LARGE2
Identifiers
Aliases	LARGE2 , PP5656, GYLTL1B, glycosyltransferase-like 1B, LARGE xylosyl- and glucuronyltransferase 2
External IDs	OMIM: 609709; MGI: 2443769; HomoloGene: 27362; GeneCards: LARGE2; OMA:LARGE2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p11.2 Start 45,921,621 bp [1] End 45,929,096 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 E1 Start 92,195,391 bp [2] End 92,205,214 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad body of pancreas skin of abdomen right lobe of thyroid gland left lobe of thyroid gland minor salivary glands skin of leg placenta anterior pituitary skin of arm Top expressed in nasolacrimal duct lip parotid gland tail of embryo genital tubercle yolk sac vestibular membrane of cochlear duct hair follicle right kidney urethra More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity catalytic activity manganese ion binding metal ion binding xylosyltransferase activity glycosyltransferase activity UDP-xylosyltransferase activity glucuronosyltransferase activity protein binding Cellular component integral component of membrane Golgi apparatus membrane Golgi membrane Biological process protein glycosylation metabolism protein O-linked mannosylation muscle cell cellular homeostasis protein O-linked glycosylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 120071 228366 Ensembl ENSG00000165905 ENSMUSG00000040434 UniProt Q8N3Y3 Q5XPT3 RefSeq (mRNA) NM_001300721 NM_001300722 NM_152312 NM_001166633 NM_001290773 NM_001290774 NM_001290775 NM_172670 RefSeq (protein) NP_001287650 NP_001287651 NP_689525 NP_001160105 NP_001277702 NP_001277703 NP_001277704 NP_766258 Location (UCSC) Chr 11: 45.92 – 45.93 Mb Chr 2: 92.2 – 92.21 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Glycosyltransferase-like protein LARGE2 is an enzyme that in humans is encoded by the GYLTL1B gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000165905 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040434 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Brockington M, Torelli S, Prandini P, Boito C, Dolatshad NF, Longman C, Brown SC, Muntoni F (Feb 2005). "Localization and functional analysis of the LARGE family of glycosyltransferases: significance for muscular dystrophy". Hum Mol Genet. 14 (5): 657–65. doi:10.1093/hmg/ddi062. PMID   15661757.
6. Grewal PK, McLaughlan JM, Moore CJ, Browning CA, Hewitt JE (Sep 2005). "Characterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathies". Glycobiology. 15 (10): 912–23. doi: 10.1093/glycob/cwi094 . PMID   15958417.
7. "Entrez Gene: GYLTL1B glycosyltransferase-like 1B".

Further reading

• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID   16341674. S2CID   69278.
• Fujimura K, Sawaki H, Sakai T, et al. (2005). "LARGE2 facilitates the maturation of alpha-dystroglycan more effectively than LARGE". Biochem. Biophys. Res. Commun. 329 (3): 1162–71. doi:10.1016/j.bbrc.2005.02.082. PMID   15752776.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC   524842 . PMID   15498874.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.