Gamma-glutamyltransferase 5

GGT5
Identifiers
Aliases	GGT5 , GGT-REL, GGTLA1, GGL, GGT 5, gamma-glutamyltransferase 5
External IDs	OMIM: 137168 MGI: 1346063 HomoloGene: 55802 GeneCards: GGT5
EC number	3.4.19.14
Gene location (Human)
Chr.	Chromosome 22 (human)
End	24,245,108 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	75,453,034 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; right coronary artery; ; left lobe of thyroid gland; ; left coronary artery; ; left uterine tube; ; canal of the cervix; ; gastric mucosa; ; tibial nerve; ; subcutaneous adipose tissue; ; popliteal artery;
	Top expressed in
	uterus; ; cervix; ; mammary gland; ; white adipose tissue; ; duodenum; ; thymus; ; subcutaneous adipose tissue; ; Paneth cell; ; adrenal gland; ; spleen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity ; peptidase activity ; acyltransferase activity ; hydrolase activity ; leukotriene-C(4) hydrolase ; glutathione hydrolase activity ; hypoglycin A gamma-glutamyl transpeptidase activity ; peptidyltransferase activity ; leukotriene C4 gamma-glutamyl transferase activity ;
Cellular component	plasma membrane ; membrane ; integral component of membrane ; intrinsic component of plasma membrane ;
Biological process	leukotriene metabolic process ; glutathione biosynthetic process ; inflammatory response ; proteolysis ; cellular amino acid metabolic process ; glutathione metabolic process ; glutathione catabolic process ; leukotriene biosynthetic process ; leukotriene D4 biosynthetic process ; fatty acid metabolic process ; protein biosynthesis ; glutamate metabolic process ; cysteine biosynthetic process ;
	Sources:Amigo / QuickGO
Orthologs
	2687
	23887
	ENSG00000099998
	ENSMUSG00000006344
	P36269
	Q9Z2A9
	NM_001099781 ; NM_001099782 ; NM_001302464 ; NM_001302465 ; NM_004121
	NM_011820 ; NM_001359425
	NP_001093251 ; NP_001093252 ; NP_001289393 ; NP_001289394 ; NP_004112
	NP_035950 ; NP_001346354
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 05, 2023

Gamma-glutamyltransferase 5 is an enzyme that in humans is encoded by the GGT5 gene.^[5]^[6]^[7]^[8]

Gamma-glutamyltransferase-like activity 1 (GGTLA1) is a member of a gene family with at least 4 members (GGTLA1, GGTLA2, GGTLA3 and GGTLA4). The enzyme encoded by GGTLA1 is related to, but distinct from, gamma-glutamyl transpeptidase (GGT). The GGTLA1 enzyme consists of a heavy and a light chain and is able to hydrolyze the gamma-glutamyl moiety of glutathione. It converts leukotriene C4 to leukotriene D4, however, it doesn't convert synthetic substrates that are commonly used to assay GGT. Its amino acid sequence shows an overall similarity of 39.5% with human GGT.^[8]

Related Research Articles

Gamma-glutamyltransferase is a transferase that catalyzes the transfer of gamma-glutamyl functional groups from molecules such as glutathione to an acceptor that may be an amino acid, a peptide or water. GGT plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione as well as drug and xenobiotic detoxification. Other lines of evidence indicate that GGT can also exert a pro-oxidant role, with regulatory effects at various levels in cellular signal transduction and cellular pathophysiology. This transferase is found in many tissues, the most notable one being the liver, and has significance in medicine as a diagnostic marker.

N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase is an enzyme that in humans is encoded by the AGA gene.

Leukotriene C4 synthase is an enzyme that in humans is encoded by the LTC4S gene.

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Phosphorylase b kinase gamma catalytic chain, testis/liver isoform is an enzyme that in humans is encoded by the PHKG2 gene.

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Ubiquitin-conjugating enzyme E2 R2 is a protein that in humans is encoded by the UBE2R2 gene.

Gamma-glutamyltransferase 1 (GGT1), also known as CD224, is a human gene.

Gamma-glutamyltransferase 7 is an enzyme that in humans is encoded by the GGT7 gene.

Zinc phosphodiesterase ELAC protein 1 is an enzyme that in humans is encoded by the ELAC1 gene.

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Lipase maturation factor 1 is an enzyme that in humans is encoded by the LMF1 gene.

Arylsulfatase E, also known as ARSE, is an enzyme that, in humans, is encoded by the ARSE gene.

Ghk.

Glutathione hydrolase (EC 3.4.19.13, glutathionase, GGT, gamma-glutamyltranspeptidase) is an enzyme. This enzyme catalyses the following chemical reaction

Leukotriene-C4 hydrolase (EC 3.4.19.14, gamma-glutamyl leukotrienase) is an enzyme. Gamma-glutamyltransferase 5 (GGT5) is a human gene which encodes an enzyme protein that belongs to this class of enzymes. This enzyme catalyses the following chemical reaction

Gamma-glutamyltransferase 6 is a protein that in humans is encoded by the GGT6 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000099998 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006344 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Heisterkamp N, Rajpert-De Meyts E, Uribe L, Forman HJ, Groffen J (Aug 1991). "Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase". Proc Natl Acad Sci U S A. 88 (14): 6303–7. Bibcode:1991PNAS...88.6303H. doi: 10.1073/pnas.88.14.6303 . PMC 52071 . PMID 1676842.
↑ Morris C, Courtay C, Geurts van Kessel A, ten Hoeve J, Heisterkamp N, Groffen J (Apr 1993). "Localization of a gamma-glutamyl-transferase-related gene family on chromosome 22". Hum Genet. 91 (1): 31–6. doi:10.1007/bf00230218. PMID 8095916. S2CID 21440198.
↑ Heisterkamp N, Groffen J, Warburton D, Sneddon TP (Apr 2008). "The human gamma-glutamyltransferase gene family". Hum Genet. 123 (4): 321–32. doi:10.1007/s00439-008-0487-7. PMID 18357469. S2CID 15916758.
1 2 "Entrez Gene: GGTLA1 gamma-glutamyltransferase-like activity 1".

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Enoiu M, Aberkane H, Salazar JF, et al. (2000). "Evidence for the pro-oxidant effect of gamma-glutamyltranspeptidase-related enzyme". Free Radic. Biol. Med. 29 (9): 825–33. doi:10.1016/S0891-5849(00)00370-1. PMID 11063908.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID 10591208.
Edelmann L, Pandita RK, Morrow BE (2000). "Low-copy repeats mediate the common 3-Mb deletion in patients with velo-cardio-facial syndrome". Am. J. Hum. Genet. 64 (4): 1076–86. doi:10.1086/302343. PMC 1377832 . PMID 10090893.
Potdar PD, Andrews KL, Nettesheim P, Ostrowski LE (1997). "Expression and regulation of gamma-glutamyl transpeptidase-related enzyme in tracheal cells". Am. J. Physiol. 273 (5 Pt 1): L1082–9. doi:10.1152/ajplung.1997.273.5.L1082. PMID 9374738.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000099998 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006344 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1676842-5] Heisterkamp N, Rajpert-De Meyts E, Uribe L, Forman HJ, Groffen J (Aug 1991). "Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase". Proc Natl Acad Sci U S A. 88 (14): 6303–7. Bibcode:1991PNAS...88.6303H. doi: 10.1073/pnas.88.14.6303 . PMC 52071 . PMID 1676842.

[pmid8095916-6] Morris C, Courtay C, Geurts van Kessel A, ten Hoeve J, Heisterkamp N, Groffen J (Apr 1993). "Localization of a gamma-glutamyl-transferase-related gene family on chromosome 22". Hum Genet. 91 (1): 31–6. doi:10.1007/bf00230218. PMID 8095916. S2CID 21440198.

[pmid18357469-7] Heisterkamp N, Groffen J, Warburton D, Sneddon TP (Apr 2008). "The human gamma-glutamyltransferase gene family". Hum Genet. 123 (4): 321–32. doi:10.1007/s00439-008-0487-7. PMID 18357469. S2CID 15916758.

[entrez-8] 1 2 "Entrez Gene: GGTLA1 gamma-glutamyltransferase-like activity 1".

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Gamma-glutamyltransferase 5

Related Research Articles

References

Further reading