A DNA vaccine is a type of vaccine that transfects a specific antigen-coding DNA sequence into the cells of an organism as a mechanism to induce an immune response.
The major histocompatibility complex (MHC) is a large locus on vertebrate DNA containing a set of closely linked polymorphic genes that code for cell surface proteins essential for the adaptive immune system. These cell surface proteins are called MHC molecules.
Heredity is a monthly peer-reviewed scientific journal published by Nature Portfolio. It covers heredity in a biological sense, i.e. genetics. The journal was founded by Ronald Fisher and C. D. Darlington in 1947 and is the official journal of The Genetics Society. From 1996 the publishing was taken over by Nature Portfolio. The editor-in-chief is Sara Goodacre.
FOXP3, also known as scurfin, is a protein involved in immune system responses. A member of the FOX protein family, FOXP3 appears to function as a master regulator of the regulatory pathway in the development and function of regulatory T cells. Regulatory T cells generally turn the immune response down. In cancer, an excess of regulatory T cell activity can prevent the immune system from destroying cancer cells. In autoimmune disease, a deficiency of regulatory T cell activity can allow other autoimmune cells to attack the body's own tissues.
Immunodysregulation polyendocrinopathy enteropathy X-linked syndrome is a rare autoimmune disease. It is one of the autoimmune polyendocrine syndromes. Most often, IPEX presents with autoimmune enteropathy, dermatitis (eczema), and autoimmune endocrinopathy, but other presentations exist.
Primary immunodeficiencies are disorders in which part of the body's immune system is missing or does not function normally. To be considered a primary immunodeficiency (PID), the immune deficiency must be inborn, not caused by secondary factors such as other disease, drug treatment, or environmental exposure to toxins. Most primary immunodeficiencies are genetic disorders; the majority are diagnosed in children under the age of one, although milder forms may not be recognized until adulthood. While there are over 430 recognized inborn errors of immunity (IEIs) as of 2019, the vast majority of which are PIDs, most are very rare. About 1 in 500 people in the United States are born with a primary immunodeficiency. Immune deficiencies can result in persistent or recurring infections, auto-inflammatory disorders, tumors, and disorders of various organs. There are currently limited treatments available for these conditions; most are specific to a particular type of PID. Research is currently evaluating the use of stem cell transplants (HSCT) and experimental gene therapies as avenues for treatment in limited subsets of PIDs.
Chemokine ligand 9 (CXCL9) is a small cytokine belonging to the CXC chemokine family that is also known as monokine induced by gamma interferon (MIG). The CXCL9 is one of the chemokine which plays role to induce chemotaxis, promote differentiation and multiplication of leukocytes, and cause tissue extravasation.
Immunogenetics or immungenetics is the branch of Medical Immunology and Medical Genetics that explores the relationship between the immune system and genetics.
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2), also known as caspase recruitment domain-containing protein 15 (CARD15) or inflammatory bowel disease protein 1 (IBD1), is a protein that in humans is encoded by the NOD2 gene located on chromosome 16. NOD2 plays an important role in the immune system. It recognizes bacterial molecules (peptidoglycans) and stimulates an immune reaction.
Clinical Infectious Diseases is a peer-reviewed medical journal published by Oxford University Press covering research on the pathogenesis, clinical investigation, medical microbiology, diagnosis, immune mechanisms, and treatment of diseases caused by infectious agents. It includes articles on antimicrobial resistance, bioterrorism, emerging infections, food safety, hospital epidemiology, and HIV/AIDS. It also features highly focused brief reports, review articles, editorials, commentaries, and supplements. The journal is published on behalf of the Infectious Diseases Society of America. The editor-in-chief is infectious disease physician Paul Sax.
Mucosal Immunology is the official publication of the Society for Mucosal Immunology (SMI).
Genes, Brain and Behavior is a peer-reviewed scientific journal covering research in the fields of behavioral, neural, and psychiatric genetics. It is published by Wiley-Blackwell on behalf of the International Behavioural and Neural Genetics Society. The journal was established in 2002 as a quarterly and is currently published monthly. G2B is a hybrid open access journal, but two years after publication all content is available for free online.
Nature Genetics is a peer-reviewed scientific journal published by Nature Portfolio. It was established in 1992. It covers research in genetics. The chief editor is Tiago Faial.
Genes & Development is a peer-reviewed scientific journal covering molecular biology, molecular genetics, cell biology, and development. It was established in 1987 and is published twice monthly by Cold Spring Harbor Laboratory Press in association with The Genetics Society.
The Journal of Leukocyte Biology is a monthly peer-reviewed medical journal covering all aspects of immunology. The focus of the journal is on leukocyte physiology and leukocyte behavior within the immune system. Content is available for free after a 12-month embargo. Since 2009, the editor-in-chief has been Luis J. Montaner. The journal is published by the Society for Leukocyte Biology.
Nature Immunology is a monthly peer-reviewed scientific journal covering immunology. It was established in 2000, as an expansion of the Nature family of journals. The editor-in-chief is Jamie D. K. Wilson.
Genesis: The Journal of Genetics and Development is a peer-reviewed scientific journal of genetics and developmental biology. It was established as Developmental Genetics in 1979 and obtained its current title in 2000. In addition to original research articles, the journal also publishes letters to the editor and technology reports relevant to the understanding of the functions of genes. The editor-in-chief is Sally A. Moody.
Soumen Basak is an Indian immunologist and virologist at the National Institute of Immunology (NII). A former fellow of the Wellcome Trust DBT India Alliance, he is known for his studies on the NF-kappaB signaling system.
Michael Joseph Mina is an American epidemiologist, immunologist and physician. He was formerly an assistant professor of Epidemiology & Immunology and Infectious Diseases at Harvard T.H. Chan School of Public Health, assistant Professor of Pathology at Brigham and Women's Hospital, Harvard Medical School, and currently Chief Medical Officer at eMed.
