Giovanna Mallucci

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Giovanna Mallucci
Congreso Futuro - 2019-01-15 - 02.jpg
Born (1963-06-29) 29 June 1963 (age 62)
Alma mater St Hilda's College, Oxford
University College London
Imperial College London
Known formechanisms of neurogenerative diseases; translational neuroscience
Awards Potamkin Prize (2021)
Scientific career
Fields Neuroscience
Neurodegeneration
Prion diseases
Institutions University of Cambridge
University of Leicester
Thesis Prion protein gene knockout in the mouse using the Cre/1oxP system  (2001)

Giovanna Rachele Mallucci (born 29 June 1963) is a British neurologist and neuroscientist. [1] Currently serving as the Founding Principal Investigator at Altos Labs, Cambridge Institute of Science, UK, since March 2022. [2] From 2017 to 2022, she was the Director of the UK Dementia Research Institute at the University of Cambridge and also served as a member of its Leadership Team. [3] Additionally, she held the position of van Geest Professor of Clinical Neuroscience at the University of Cambridge from 2014 to 2022. She is a specialist in neurodegenerative diseases [4] [5] [6]

Contents

Education

She attended Haberdashers' Aske's School for Girls, Elstree. [7] Mallucci completed her undergraduate studies at the University of Oxford, where she earned a BA (Hons) in Physiological Sciences in 1985. [8] She went on to obtain an MB BS (Hons) from University College London in 1988. [9] In 2001, she received a PhD from the University of London, followed by specialist accreditation (CSST) in Neurology in 2005. [10]

Career and research

Mallucci has held numerous positions throughout her career. From 2017 to 2022, she served as the Centre Director of the UK Dementia Research Institute at the University of Cambridge and was a member of the UK DRI Leadership Team. [3] [11] [12]

She also held the title of van Geest Professor of Clinical Neuroscience at the University of Cambridge from 2014 to 2022. [13] In addition to her academic roles, Mallucci was an Honorary Consultant Neurologist at Addenbrooke's Hospital, Cambridge, from 2012 to 2022. [14] Prior to these roles, she worked at the MRC Toxicology Unit in Leicester, where she was the Head of Neurobiology from 2008 to 2014 [15] and a Professor of Neuroscience at the University of Leicester. [16]

Her editorial activity includes serving as Deputy Editor for Brain since 2021, and she has held editorial positions at several journals, including the European Journal of Neuroscience and Brain Plasticity. [17]

Mallucci has made transformative discoveries in the biology of protein-misfolding in neurodegeneration. [18] She discovered the potential for reversibility of early neurodegeneration. [9] She pioneered understanding how dysregulated homeostasis responses, notably the unfolded protein response (UPR), mediate neuronal loss. [19] She established the principle of therapeutic UPR modulation, discovering the first small molecule to prevent neurodegeneration and repurposed drugs inhibiting the pathway, now in clinical trials.  [20] She showed subcellular UPR signalling creates translational ‘safe havens’ for mitochondria. [21] She discovered the role of the cold-shock protein, RBM3, in synapse regeneration and its therapeutic potential for neuroprotection.  [22] Her work redefines the dementia therapy landscape. [23]

Awards

References

  1. ↑ "Professor Giovanna Mallucci :: Cambridge Neuroscience".
  2. ↑ "Giovanna Mallucci". Sorbonne Université.
  3. 1 2 "A fond farewell to Cambridge Centre Director Prof Giovanna". www.ukdri.ac.uk. 10 September 2024.
  4. ↑ Gallagher, James (10 October 2013). "Alzheimer's breakthrough hailed as 'turning point'". BBC News.
  5. ↑ Gallagher, James (20 April 2017). "Experts excited by brain 'wonder-drug'". BBC News.
  6. ↑ "Giovanna Mallucci - 24 Nov 2015 - Oxford Parkinson's Disease Centre".
  7. ↑ "Mallucci, Prof. Giovanna Rachele, (born 29 June 1963), Van Geest Professor of Clinical Neurosciences, University of Cambridge, since 2014; Associate Director, UK Dementia Research Institute at University of Cambridge, since 2017; Fellow, Churchill College, Cambridge, since 2018; Hon. Consultant Neurologist, Addenbrooke's Hospital, Cambridge, since 2012." WHO'S WHO & WHO WAS WHO. 1 Dec. 2015
  8. ↑ "Addenbrooke's Hospital | Cambridge University Hospitals". www.cuh.org.uk. Retrieved 2017-06-14.
  9. 1 2 Watts, Geoff (15 February 2020). "Giovanna Mallucci: redefining neurodegeneration". The Lancet. p. 486. doi:10.1016/S0140-6736(20)30295-6.
  10. ↑ "Professor Giovanna Mallucci – Univ. of Cambridge". talks.ox.ac.uk.
  11. ↑ "Cambridge Biomedical Campus" . Retrieved 2018-07-06.
  12. ↑ "UK Dementia Research Institute". UK Dementia Research Institute. 2017-06-14. Retrieved 2017-06-14.
  13. ↑ Brackley, Paul. "How Professor Giovanna Mallucci will lead Cambridge fight against dementia". Cambridge Independent. Retrieved 2017-06-14.
  14. ↑ "The Edinburgh Parkinson's Lecture 2018". Edinburgh Parkinsons. Retrieved 2025-03-24.
  15. ↑ "Neurodegeneration: Molecules to medicines". www.dpag.ox.ac.uk. Retrieved 2025-03-24.
  16. ↑ "King's College London - Home". www.kcl.ac.uk. Retrieved 2017-06-14.
  17. ↑ "Professor Giovanna Mallucci :: Cambridge Neuroscience". www.neuroscience.cam.ac.uk. Retrieved 2017-06-14.
  18. ↑ "Update on the pathophysiology of prion diseases". Advances in Clinical Neuroscience and Rehabilitation. 2014-09-30.
  19. ↑ Kim, Pitna (2024-03-01). "Understanding the Unfolded Protein Response (UPR) Pathway: Insights into Neuropsychiatric Disorders and Therapeutic Potentials". Biomolecules & Therapeutics. 32 (2): 183–191. doi:10.4062/biomolther.2023.181. ISSN   1976-9148. PMC   10902702 . PMID   38410073.
  20. ↑ Hughes, Daniel T.; Halliday, Mark; Smith, Heather L.; Verity, Nicholas C.; Molloy, Colin; Radford, Helois; Butcher, Adrian J.; Mallucci, Giovanna R. (2020-08-11). "Targeting the kinase insert loop of PERK selectively modulates PERK signaling without systemic toxicity in mice" . Science Signaling. 13 (644): eabb4749. doi:10.1126/scisignal.abb4749.
  21. ↑ Brar, Karinder K.; Hughes, Daniel T.; Morris, Jordan L.; Subramanian, Kelly; Krishna, Shivaani; Gao, Fei; Rieder, Lara-Sophie; Uhrig, Sebastian; Freeman, Joshua; Smith, Heather L.; Jukes-Jones, Rebekkah; Avezov, Edward; Nunnari, Jodi; Prudent, Julien; Butcher, Adrian J. (2024-08-08). "PERK-ATAD3A interaction provides a subcellular safe haven for protein synthesis during ER stress" . Science. 385 (6712): eadp7114. doi: 10.1126/science.adp7114 .
  22. ↑ "The 'cold-shock' protein that could lead to a cure for dementia". www.pilgrimsfriend.org.uk. Retrieved 2025-03-24.
  23. ↑ Sample, Ian (2022-11-22). "'This looks like the real deal': are we inching closer to a treatment for Alzheimer's?". The Guardian. ISSN   0261-3077 . Retrieved 2025-03-24.
  24. ↑ "Potamkin Prize for Research 2021 | Giovanna Mallucci, MD". American Brain Foundation. Retrieved 2025-03-24.
  25. ↑ "Prof Giovanna Mallucci receives Potamkin Prize, regarded the". www.ukdri.ac.uk. 2024-09-10. Retrieved 2025-03-24.
  26. ↑ "The Academy of Medical Sciences announces new Fellows for 2017 | University of Cambridge". www.cam.ac.uk. 2017-05-08. Retrieved 2025-03-24.
  27. 1 2 "Professor Giovanna Mallucci awarded major international prize for research on Alzheimer's disease". Support Cambridge. Retrieved 2025-03-24.
  28. ↑ https://www.bna.org.uk/static/uploads/resources/Xmas2015_programme_online.pdf Giovanna Mallucci, University of Cambridge Giovanna Mallucci is Professor of Clinical Neurosciences at the University of Cambridge and an Honorary
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