Golph3

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Golgi phosphoprotein 3 (GOLPH3) is a human protein encoded by GOLPH3 gene. It is a peripheral membrane protein of the Golgi that probably has a regulatory role in Golgi trafficking. [1]

Clinical significance

Golph 3 expression is associated with poor prognosis of various cancers of gastrointestinal tract, such as gastric and esophageal squamous cell carcinoma. [2] [3] Higher expression of GOLPH3 is reported to be associated with greater sensitivity of colorectal cancer to Fluorouracil therapy. [4]

Notes and references

  1. ↑ "Entrez Gene: GOLPH3 golgi phosphoprotein 3".
  2. ↑ Wang JH (2013). "High Expression of GOLPH3 in Esophageal Squamous Cell Carcinoma Correlates with Poor Prognosis". PLOS ONE. 7 (10) e45622. Bibcode:2012PLoSO...745622W. doi: 10.1371/journal.pone.0045622 . PMC   3462781 . PMID   23056210.
  3. ↑ Hu BS (Feb 2013). "Overexpression of GOLPH3 is associated with poor clinical outcome in gastric cancer". Tumour Biol. 34 (1): 515–20. doi:10.1007/s13277-012-0576-z. PMID   23132295. S2CID   6309770.
  4. ↑ Wang Z (Jan 2014). "GOLPH3 predicts survival of colorectal cancer patients treated with 5-fluorouracil-based adjuvant chemotherapy". J. Transl. Med. 12 (1): 15. doi: 10.1186/1479-5876-12-15 . PMC   4029222 . PMID   24444035.


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