HECTD4

HECTD4
Identifiers
Aliases	HECTD4 , C12orf51, POTAGE, HECT domain E3 ubiquitin protein ligase 4, HEEL, C12ord51
External IDs	MGI: 3647820 HomoloGene: 28297 GeneCards: HECTD4
Gene location (Human)
Chr.	Chromosome 12 (human)
End	112,382,439 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	121,368,577 bp
Gene ontology
Molecular function	• transferase activity ; • ubiquitin-protein transferase activity ; • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity ;
Cellular component	• integral component of membrane ; • membrane ; • cytoplasm ;
Biological process	• protein ubiquitination ; • glucose homeostasis ; • glucose metabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	283450
	269700
	ENSG00000173064
	ENSMUSG00000042744
	Q9Y4D8
	n/a
	NM_173813 ; NM_001109662
	NM_181421
	NP_001103132
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 21, 2020

HECT domain E3 ubiquitin protein ligase 4 is a protein that in humans is encoded by the HECTD4 gene. ^[5]

Related Research Articles

ITCH is a HECT domain E3 ubiquitin ligase that is ablated in non-agouti-lethal 18H mice. Itchy mice develop a severe immunological phenotype after birth that includes hyperplasia of lymphoid and hematopoietic cells, and stomach and lung inflammation. In humans ITCH deficiency causes altered physical growth, craniofacial morphology defects, defective muscle development, and aberrant immune system function. ITCH contains multiple amino acids that are phosphorylated and ubiquitinated.

E3 ubiquitin-protein ligase SMURF1 is an enzyme that in humans is encoded by the SMURF1 gene.

RING-box protein 2 is a protein that in humans is encoded by the RNF7 gene.

E3 ubiquitin-protein ligase HUWE1 is an enzyme that in humans is encoded by the HUWE1 gene.

E3 ubiquitin-protein ligase UBR5 is an enzyme that in humans is encoded by the UBR5 gene.

E3 ubiquitin-protein ligase NRDP1 is an enzyme that in humans is encoded by the RNF41 gene.

Ubiquitin-associated domain-containing protein 1 is a protein that in humans is encoded by the UBAC1 gene.

ETS-related transcription factor Elf-4 is a protein that in humans is encoded by the ELF4 gene.

F-box/WD repeat-containing protein 5 is a protein that in humans is encoded by the FBXW5 gene.

Endoplasmic reticulum lectin 1 is a protein that in humans is encoded by the ERLEC1 gene.

Probable E3 ubiquitin-protein ligase HERC5 is an enzyme that in humans is encoded by the HERC5 gene.

Ubiquitin-protein ligase E3C is an enzyme that in humans is encoded by the UBE3C gene.

Testis-specific basic protein Y 2 also known as basic charge, Y-linked 2 is a protein that in humans is encoded by the BPY2 gene which resides on the Y chromosome.

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 is a protein that in humans is encoded by the HECW1 gene. In human it has 1606 amino acids and isoelectric point of 5.18.

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 is a protein that in humans is encoded by the HECW2 gene.

Deltex E3 ubiquitin ligase 3 is a protein that in humans is encoded by the DTX3 gene.

HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 is a protein that in humans is encoded by the HACE1 gene.

Ring finger protein 167 is a protein that in humans is encoded by the RNF167 gene.

RNF144A is an E3 ubiquitin ligase belonging to the RING-between RING (RBR) family of ubiquitin ligases, whose specific members have been shown to function as RING-HECT hybrid E3 ligases. RNF144A is most closely related to RNF144B at the protein level, and the two proteins together comprise a subdomain within the RBR family of proteins. The ubiquitin ligase activity of RNF144A catalyzes ubiquitin linkages at the K6-, K11- and K48- positions of ubiquitin in vitro, and is regulated by self-association through its transmembrane domain.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000173064 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042744 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: HECT domain E3 ubiquitin protein ligase 4" . Retrieved 2016-10-24.

HECTD4

Related Research Articles

References

Further reading