HEPN1

Last updated
HEPN1
Identifiers
Aliases HEPN1 , hepatocellular carcinoma, down-regulated 1
External IDs OMIM: 611641 HomoloGene: 134601 GeneCards: HEPN1
Gene location (Human)
Ideogram human chromosome 11.svg
Chr. Chromosome 11 (human) [1]
Human chromosome 11 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 11q24.2Start124,919,244 bp [1]
End124,920,677 bp [1]
Orthologs
SpeciesHumanMouse
Entrez

641654

n/a

Ensembl

ENSG00000221932

n/a

UniProt

Q6WQI6

n/a

RefSeq (mRNA)

NM_001037558

n/a

RefSeq (protein)

NP_001032647

n/a

Location (UCSC) Chr 11: 124.92 – 124.92 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

Hepatocellular carcinoma, down-regulated 1 is a protein that in humans is encoded by the HEPN1 gene. [3]

Contents

Function

This gene is expressed in the liver, and encodes a short peptide that is localized predominantly to the cytoplasm. Transient transfection studies showed that expression of this gene significantly inhibited cell growth, and it may have a role in apoptosis. Expression of this gene is downregulated or lost in hepatocellular carcinomas (HCC), suggesting that loss of this gene is involved in carcinogenesis of hepatocytes. [4] Also to note is that this gene maps to the 3'-noncoding region of HEPACAM gene (GeneID:220296) on the antisense strand. [5]

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000221932 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑ "Entrez Gene: Hepatocellular carcinoma, down-regulated 1" . Retrieved 2017-09-12.
  4. ↑ Moh MC, Lee LH, Yang X, Shen S (2003). "HEPN1, a novel gene that is frequently down-regulated in hepatocellular carcinoma, suppresses cell growth and induces apoptosis in HepG2 cells". J Hepatol. 39 (4): 580–6. doi:10.1016/s0168-8278(03)00359-3. PMID   12971969.
  5. ↑ Chung Moh M, Hoon Lee L, Shen S (2005). "Cloning and characterization of hepaCAM, a novel Ig-like cell adhesion molecule suppressed in human hepatocellular carcinoma". J Hepatol. 42 (6): 833–41. doi:10.1016/j.jhep.2005.01.025. PMID   15885354.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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