HLA-A10

Last updated June 27, 2024

HLA-A10 is a broad antigen HLA-A serotype. The ancestral A10 type is believed to be A*2601, which via gene conversion with other HLA-A alleles produced A*2501, A*3401, A*4301 and A*6601.^[1] A10 serotypes in general show a pattern of more recent expansion. A34 is an excellent example, appearing to have expanded from the middle east, with linkage disequilibrium with B alleles into Austronesia,^[2] South Pacific,^[3] Philippines^[4] and as far north as Taiwan (where it is found in the Taiwan Ami and Yami tribal groups but rare in ethnic Chinese nor in Hong Kong Chinese). A*66 appears to have expanded from North Africa into the Middle East or Europe and A26 appears to have expanded Black Sea and, after the initial settlement from the southern West Pacific Rim peoples, into Japan . Whether this is a secondary migration from Africa or a re-expansion from within Eurasia is unclear.

Subpages for A10 serotypes
Serotypes of A10 HLA-A gene products
HLA-A25
HLA-A26
HLA-A34
HLA-A43
HLA-A66

Related Research Articles

<span class="mw-page-title-main">HLA-A1</span> Human leukocyte antigen serotype

HLA-A1 (A1) is a human leukocyte antigen serotype within HLA-A "A" serotype group. The serotype is determined by the antibody recognition of α¹ subset of HLA-A α-chains. For A1, the alpha "A" chain are encoded by the HLA-A*01 allele group and the β-chain are encoded by B2M locus. This group currently is dominated by A*01:01. A1 and A*01 are almost synonymous in meaning. A1 is more common in Europe than elsewhere, it is part of a long haplotype that appears to have been frequent in the ancient peoples of Northwestern Europe. A1 is a frequent component of the AH8.1 haplotype. A1 serotype positivity is roughly linked to a large number of inflammatory diseases and conditions believed to have immune system involvement. Because of its linkage within the AH8.1 haplotype many studies showed association with A1 or A1,B8 only later to show the association drift toward the class II region gene alleles, DR3 and DQ2.5. While it is not clear what role A1 has in infectious disease, some linkage with infection rates in HIV remain associated within the A1 region of the haplotype.

HLA-A3 (A3) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α³ subset of HLA-A α-chains. For A3, the alpha, "A", chain are encoded by the HLA-A*03 allele group and the β-chain are encoded by B2M locus. This group currently is dominated by A*03:01. A3 and A*03 are almost synonymous in meaning. A3 is more common in Europe, it is part of the longest known multigene haplotype, A3~B7~DR15~DQ6.

<span class="mw-page-title-main">HLA-A9</span> Human leukocyte antigen serotype

HLA-A9 (A9) is a broad antigen HLA-A serotype that recognized the HLA-A23 and HLA-A24 serotypes. A*2402 appears to have evolved from A*23 alleles by a process of gene conversion. The A23 is more common in Africa and regions proximal to Africa. A24 is at very high frequencies in Austronesia and certain indigenous peoples of the Arctic, North America, South America and West Pacific Rim. While it is common over most of Eurasia, it is found at low abundance in NW Europe. A24 appears to have been carried by the first colonizers of South Eastern Asia.

HLA-A36 (A36) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α³⁶ subset of HLA-A α-chains. For A36, the alpha "A" chain are encoded by the HLA-A*36 allele group and the β-chain are encoded by B2M locus. This group currently is dominated by A*3601. A36 and A*36 are almost synonymous in meaning.

HLA-A80 (A80) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α⁸⁰ subset of HLA-A α-chains. For A80, the alpha "A" chain are encoded by the HLA-A*80 allele group and the β-chain are encoded by B2M locus. This group currently is dominated by A*8001. A80 and A*80 are almost synonymous in meaning.

HLA-A69 (A69) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α⁶⁹ subset of HLA-A α-chains. For A69, the alpha "A" chain are encoded by the HLA-A*69 allele group and the β-chain are encoded by B2M locus. This group currently is dominated by A*6901. A69 and A*69 are almost synonymous in meaning. A69 is a split antigen of the broad antigen serotype A28. A69 is a sister serotype of A68.

<span class="mw-page-title-main">HLA-A68</span> Human leukocyte antigen serotype

HLA-A68 (A68) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α⁶⁸ subset of HLA-A α-chains. For A68, the alpha "A" chain are encoded by the HLA-A*68 allele group and the β-chain are encoded by B2M locus. A68 and A*68 are almost synonymous in meaning. A68 is a split antigen of the broad antigen serotype A28. A68 is a sister serotype of A69.

<span class="mw-page-title-main">HLA-A24</span> Human leukocyte antigen serotype

HLA-A24 (A24) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α²⁴ subset of HLA-A α-chains. For A24, the alpha, "A", chain are encoded by the HLA-A*24 allele group and the β-chain are encoded by B2M locus. This group currently is dominated by A*2402. A24 and A*24 are almost synonymous in meaning. A24 is a split antigen of the broad antigen HLA-A9 and it is a sister serotype of HLA-A23.

HLA-A25 (A25) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α²⁵ subset of HLA-A α-chains. For A25, the alpha "A" chain are encoded by the HLA-A*25 allele group and the β-chain are encoded by B2M locus. This group currently is dominated by A*2501. A25 and A*25 are almost synonymous in meaning. A25 is a split antigen of the broad antigen serotype A10. A25 is a sister serotype of A26, A34, A43, and A66.

HLA-A43 (A43) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α⁴³ subset of HLA-A α-chains. For A43, the alpha "A" chain are encoded by the HLA-A*43 allele group and the β-chain are encoded by B2M locus. This group currently is dominated by A*4301. A43 and A*43 are almost synonymous in meaning. A43 is a split antigen of the broad antigen serotype A10. A43 is a sister serotype of A25, A26, A34, and A66.

HLA-A66 (A66) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α⁶⁶ subset of HLA-A α-chains. For A66, the alpha "A" chain are encoded by the HLA-A*66 allele group and the β-chain are encoded by B2M locus. A66 and A*66 are almost synonymous in meaning. A66 is a split antigen of the broad antigen serotype A10. A66 is a sister serotype of A25, A26, A34, and A43.

HLA-A33 (A33) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α³³ subset of HLA-A α-chains. For A33, the alpha "A" chain are encoded by the HLA-A*33 allele group and the β-chain are encoded by B2M locus. A33 and A*33 are almost synonymous in meaning. A33 is a split antigen of the broad antigen serotype A19. A33 is a sister serotype of A29, A30, A31, A32, and A74.

HLA-A32 (A32) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α³² subset of HLA-A α-chains. For A32, the alpha "A" chain are encoded by the HLA-A*32 allele group and the β-chain are encoded by B2M locus. This group currently is dominated by A*3201. A32 and A*32 are almost synonymous in meaning. A32 is a split antigen of the broad antigen serotype A19. A32 is a sister serotype of A29, A30, A31, A33, and A74.

HLA-A34 (A34) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α³⁴ subset of HLA-A α-chains. For A34, the alpha "A" chain are encoded by the HLA-A*34 allele group and the β-chain are encoded by B2M locus. A34 and A*34 are almost synonymous in meaning. A34 is a split antigen of the broad antigen serotype A10. A34 is a sister serotype of A25, A26, A43, and A66.

HLA-A26 (A26) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α²⁶ subset of HLA-A α-chains. For A26, the alpha "A" chain are encoded by the HLA-A*26 allele group and the β-chain are encoded by B2M locus. This group currently is dominated by A*2601. A26 and A*26 are almost synonymous in meaning. A26 is a split antigen of the broad antigen serotype A10. A26 is a sister serotype of A25, A34, A43, and A66.

HLA-A30 (A30) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α³⁰ subset of HLA-A α-chains. For A30, the alpha "A" chain are encoded by the HLA-A*30 allele group and the β-chain are encoded by B2M locus. A30 and A*30 are almost synonymous in meaning. A30 is a split antigen of the broad antigen serotype A19. A30 is a sister serotype of A29, A31, A32, A33, and A74.

HLA-B67 (B67) is an HLA-B serotype. The serotype identifies the more common HLA-B*67 gene products. B67 is region specific recombinant haplotype formed by the gene conversion of B*39, an allele common along the Northwest Pacific Rim, and B7, B22, or B27.

HLA-B51 (B51) is an HLA-B serotype. The serotype identifies the more common HLA-B*51 gene products.

<span class="mw-page-title-main">HLA-B52</span> Human leukocyte antigen serotype

HLA-B52 (B52) is an HLA-B serotype. The serotype identifies the more common HLA-B*52 gene products.

<span class="mw-page-title-main">HLA-B38</span> Human leukocyte antigen serotype

HLA-B38 (B38) is an HLA-B serotype. The serotype identifies the B*38 allele products of the HLA-B gene-locus.

References

↑ Madrigal JA, Hildebrand WH, Belich MP, et al. (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens. 41 (2): 72–80. doi:10.1111/j.1399-0039.1993.tb01982.x. PMID 8475492.
↑ Bugawan TL, Mack SJ, Stoneking M, Saha M, Beck HP, Erlich HA (1999). "HLA class I allele distributions in six Pacific/Asian populations: evidence of selection at the HLA-A locus". Tissue Antigens. 53 (4 Pt 1): 311–9. doi:10.1034/j.1399-0039.1999.530401.x. PMID 10323335.
↑ Maitland K, Bunce M, Harding RM, et al. (2004). "HLA class-I and class-II allele frequencies and two-locus haplotypes in Melanesians of Vanuatu and New Caledonia" (PDF). Tissue Antigens. 64 (6): 678–86. doi:10.1111/j.1399-0039.2004.00328.x. hdl: 10044/1/28296 . PMID 15546341.
↑ Bugawan TL, Klitz W, Alejandrino M, et al. (2002). "The association of specific HLA class I and II alleles with type 1 diabetes among Filipinos". Tissue Antigens. 59 (6): 452–69. doi:10.1034/j.1399-0039.2002.590602.x. PMID 12445315.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[pmid8475492-1] Madrigal JA, Hildebrand WH, Belich MP, et al. (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens. 41 (2): 72–80. doi:10.1111/j.1399-0039.1993.tb01982.x. PMID 8475492.

[pmid10323335-2] Bugawan TL, Mack SJ, Stoneking M, Saha M, Beck HP, Erlich HA (1999). "HLA class I allele distributions in six Pacific/Asian populations: evidence of selection at the HLA-A locus". Tissue Antigens. 53 (4 Pt 1): 311–9. doi:10.1034/j.1399-0039.1999.530401.x. PMID 10323335.

[pmid15546341-3] Maitland K, Bunce M, Harding RM, et al. (2004). "HLA class-I and class-II allele frequencies and two-locus haplotypes in Melanesians of Vanuatu and New Caledonia" (PDF). Tissue Antigens. 64 (6): 678–86. doi:10.1111/j.1399-0039.2004.00328.x. hdl: 10044/1/28296 . PMID 15546341.

[pmid12445315-4] Bugawan TL, Klitz W, Alejandrino M, et al. (2002). "The association of specific HLA class I and II alleles with type 1 diabetes among Filipinos". Tissue Antigens. 59 (6): 452–69. doi:10.1034/j.1399-0039.2002.590602.x. PMID 12445315.

[1]

[2]

[3]

[4]