HLA-A19

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HLA-A19 (A19) is a human leukocyte antigen HLA-A serotype that may recognize the A29, A30, A31, A32, A33, and A74 serotypes. [1] While these haplotypes are found all over the globe, their combined frequencies are higher in Sub Saharan Africa; frequencies tend to decline away from Africa.

Clinical significance

HLA-A19 has been implicated in a number of diseases, including renal cell carcinoma, Kaposi's sarcoma, vitiligo, and others; antibodies to HLA-A19 were recorded in 86% of infertile men and 92% of infertile women. [1] [2]

Subpages for A19 serotypes
Split antigen serotypes

of A19 HLA-A

HLA-A29
HLA-A30
HLA-A31
HLA-A32
HLA-A33
HLA-A74

References

  1. 1 2 Shankarkumar, Umapathy; Ghosh, Kanjaksha; Mohanty, Dipika (September 2002). "Defining the allelic variants of HLA A19 in the western Indian population" . Human Immunology. 63 (9): 779–782. doi:10.1016/S0198-8859(02)00424-X.
  2. ↑ Genco, Petrina V.; Mathur, Subbi; Oliver Williamson, H.; Rust, Philip F.; Glassman, Armand B.; Hugh Fudenberg, H. (1984-10-01). "Antibodies to A19 and Bw35 complexes of human leukocyte antigens are present in infertile subjects with sperm antibodies*†‡" . Fertility and Sterility. 42 (4): 554–560. doi: 10.1016/S0015-0282(16)48138-0 . ISSN   0015-0282.
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