HSD17B11

HSD17B11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YB1
Identifiers
Aliases	HSD17B11 , 17-BETA-HSD11, 17-BETA-HSDXI, 17BHSD11, DHRS8, PAN1B, RETSDR2, SDR16C2, hydroxysteroid (17-beta) dehydrogenase 11, hydroxysteroid 17-beta dehydrogenase 11
External IDs	OMIM: 612831; MGI: 2149821; HomoloGene: 69209; GeneCards: HSD17B11; OMA:HSD17B11 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q22.1 Start 87,336,515 bp [1] End 87,391,188 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 E5 Start 104,137,628 bp [2] End 104,169,785 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa mucosa of colon duodenum mucosa of sigmoid colon rectum mucosa of ileum monocyte gallbladder mucosa of transverse colon blood Top expressed in vestibular membrane of cochlear duct pyloric antrum epithelium of stomach mucous cell of stomach iris intestinal villus stria vascularis Ileal epithelium left lobe of liver duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity steroid dehydrogenase activity estradiol 17-beta-dehydrogenase activity Cellular component cytoplasm extracellular region cytosol lipid droplet Biological process estrogen biosynthetic process androgen catabolic process lipid metabolism steroid biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51170 114664 Ensembl ENSG00000198189 ENSMUSG00000029311 UniProt Q8NBQ5 Q9EQ06 RefSeq (mRNA) NM_016245 NM_053262 RefSeq (protein) NP_057329 NP_444492 Location (UCSC) Chr 4: 87.34 – 87.39 Mb Chr 5: 104.14 – 104.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Estradiol 17-beta-dehydrogenase 11 is an enzyme that in humans is encoded by the HSD17B11 gene. ^{[5] [6] [7] [8]}

HSD17B11 expression has been linked to higher survival rates for lung cancer patients. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000198189 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029311 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Brereton P, Suzuki T, Sasano H, Li K, Duarte C, Obeyesekere V, Haeseleer F, Palczewski K, Smith I, Komesaroff P, Krozowski Z (January 2001). "Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung". Molecular and Cellular Endocrinology. 171 (1–2): 111–7. doi:10.1016/S0303-7207(00)00417-2. PMID   11165019. S2CID   54263651.
6. Chai Z, Brereton P, Suzuki T, Sasano H, Obeyesekere V, Escher G, Saffery R, Fuller P, Enriquez C, Krozowski Z (May 2003). "17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells". Endocrinology. 144 (5): 2084–91. doi: 10.1210/en.2002-221030 . PMID   12697717.
7. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (March 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chemico-Biological Interactions. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC   2896744 . PMID   19027726.
8. "Entrez Gene: HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11".
9. "Research update from the MCM team (March 2024)". World Community Grid. 14 March 2024. Retrieved 21 May 2024.

Further reading

• Li KX, Smith RE, Krozowski ZS (1999). "Cloning and expression of a novel tissue specific 17beta-hydroxysteroid dehydrogenase". Endocrine Research. 24 (3–4): 663–7. doi:10.3109/07435809809032667. PMID   9888557.
• Haeseleer F, Palczewski K (2000). "Short-chain dehydrogenases/Reductases in retina". Vertebrate Phototransduction and the Visual Cycle, Part B. Methods in Enzymology. Vol. 316. pp. 372–83. doi:10.1016/S0076-6879(00)16736-9. ISBN   978-0-12-182217-0. PMID   10800688.
• Hartmann TB, Thiel D, Dummer R, Schadendorf D, Eichmüller S (February 2004). "SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma". The British Journal of Dermatology. 150 (2): 252–8. doi:10.1111/j.1365-2133.2004.05651.x. PMID   14996095. S2CID   42495130.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.