HSD17B11

HSD17B11
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1YB1
Identifiers
Aliases	HSD17B11 , 17-BETA-HSD11, 17-BETA-HSDXI, 17BHSD11, DHRS8, PAN1B, RETSDR2, SDR16C2, hydroxysteroid (17-beta) dehydrogenase 11, hydroxysteroid 17-beta dehydrogenase 11
External IDs	OMIM: 612831 MGI: 2149821 HomoloGene: 69209 GeneCards: HSD17B11
Gene location (Human)
Chr.	Chromosome 4 (human)
End	87,391,188 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	104,169,785 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; duodenum; ; rectum; ; monocyte; ; gallbladder; ; blood; ; visceral pleura; ; germinal epithelium; ; gastric mucosa; ; right lung;
	Top expressed in
	pyloric antrum; ; epithelium of stomach; ; mucous cell of stomach; ; iris; ; intestinal villus; ; stria vascularis; ; left lobe of liver; ; duodenum; ; jejunum; ; ciliary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity ; steroid dehydrogenase activity ; estradiol 17-beta-dehydrogenase activity ;
Cellular component	cytoplasm ; extracellular region ; cytosol ; lipid droplet ;
Biological process	estrogen biosynthetic process ; androgen catabolic process ; lipid metabolism ; steroid biosynthetic process ;
	Sources:Amigo / QuickGO
Orthologs
	51170
	114664
	ENSG00000198189
	ENSMUSG00000029311
	Q8NBQ5
	Q9EQ06
	NM_016245
	NM_053262
	NP_057329
	NP_444492
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated May 22, 2024

Estradiol 17-beta-dehydrogenase 11 is an enzyme that in humans is encoded by the HSD17B11 gene.^[5]^[6]^[7]^[8]

HSD17B11 expression has been linked to higher survival rates for lung cancer patients.^[9]

Related Research Articles

Corticosteroid 11-β-dehydrogenase isozyme 2 also known as 11-β-hydroxysteroid dehydrogenase 2 is an enzyme that in humans is encoded by the HSD11B2 gene.

17β-Hydroxysteroid dehydrogenases, also 17-ketosteroid reductases (17-KSR), are a group of alcohol oxidoreductases which catalyze the reduction of 17-ketosteroids and the dehydrogenation of 17β-hydroxysteroids in steroidogenesis and steroid metabolism. This includes interconversion of DHEA and androstenediol, androstenedione and testosterone, and estrone and estradiol.

17β-Hydroxysteroid dehydrogenase 1 (17β-HSD1) is an enzyme that in humans is encoded by the HSD17B1 gene. This enzyme oxidizes or reduces the C17 hydroxy/keto group of androgens and estrogens and hence is able to regulate the potency of these sex steroids

HSD3B1 is a human gene that encodes for a 3beta-hydroxysteroid dehydrogenase/delta(5)-delta(4)isomerase type I or hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1. While it can carry out the same function as HSD3B2, it localizes primarily to different tissues, such as the placenta and nonsteroidogenic tissues. Its requirement for the production of progesterone by the placenta, which has a vital role in pregnancy, may be one reason why no disease based on mutations in this gene has been identified to date, besides prostate cancer.

In enzymology, an ADP-specific glucokinase also known as ADP-dependent glucokinase is an enzyme that catalyzes the chemical reaction

Aldo-keto reductase family 1 member C3 (AKR1C3), also known as 17β-hydroxysteroid dehydrogenase type 5 or 3α-hydroxysteroid dehydrogenase type 2 (3α-HSD2) is a steroidogenic enzyme that in humans is encoded by the AKR1C3 gene.

17-β-Hydroxysteroid dehydrogenase X (HSD10) also known as 3-hydroxyacyl-CoA dehydrogenase type-2 is a mitochondrial enzyme that in humans is encoded by the HSD17B10 gene. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. Human HSD10 cDNA was cloned from the brain (NM_004493), and the resulting protein, a homotetramer, was first characterized as a short chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD). Active sites of this enzyme can accommodate different substrates; 17β-HSD10 is involved in the oxidation of isoleucine, branched-chain fatty acids, and xenobiotics as well as the metabolism of sex hormones and neuroactive steroids.

D-bifunctional protein (DBP), also known as peroxisomal multifunctional enzyme type 2 (MFP-2), as well as 17β-hydroxysteroid dehydrogenase type IV is a protein that in humans is encoded by the HSD17B4 gene. It's an alcohol oxidoreductase, specifically 17β-Hydroxysteroid dehydrogenase. It is involved in fatty acid β-oxidation and steroid metabolism.

17β-Hydroxysteroid dehydrogenase 2 (17β-HSD2) is an enzyme of the 17β-hydroxysteroid dehydrogenase (17β-HSD) family that in humans is encoded by the HSD17B2 gene.

3-keto-steroid reductase is an enzyme that in humans is encoded by the HSD17B7 gene.

17β-Hydroxysteroid dehydrogenase 3 (17β-HSD3) is an enzyme that in humans is encoded by the HSD17B3 gene and is involved in androgen steroidogenesis.

Estradiol 17 beta-dehydrogenase 8 is an enzyme that in humans is encoded by the HSD17B8 gene.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 is a protein that in humans is encoded by the GNG7 gene.

Estradiol 17-beta-dehydrogenase 12 is an enzyme that in humans is encoded by the HSD17B12 gene.

Short-chain dehydrogenase/reductase 3 is an enzyme that in humans is encoded by the DHRS3 gene.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 is a protein that in humans is encoded by the GNG4 gene.

Hydroxysteroid 17-beta dehydrogenase 6 is an enzyme that in humans is encoded by the HSD17B6 gene.

NADH-cytochrome b5 reductase 1 is an enzyme that in humans is encoded by the CYB5R1 gene.

L-asparaginase is an enzyme that in humans is encoded by the ASRGL1 gene.

Krueppel-like factor 17 is a protein that in humans is encoded by the KLF17 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198189 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029311 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Brereton P, Suzuki T, Sasano H, Li K, Duarte C, Obeyesekere V, Haeseleer F, Palczewski K, Smith I, Komesaroff P, Krozowski Z (January 2001). "Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung". Molecular and Cellular Endocrinology. 171 (1–2): 111–7. doi:10.1016/S0303-7207(00)00417-2. PMID 11165019. S2CID 54263651.
↑ Chai Z, Brereton P, Suzuki T, Sasano H, Obeyesekere V, Escher G, Saffery R, Fuller P, Enriquez C, Krozowski Z (May 2003). "17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells". Endocrinology. 144 (5): 2084–91. doi: 10.1210/en.2002-221030 . PMID 12697717.
↑ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (March 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chemico-Biological Interactions. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744 . PMID 19027726.
↑ "Entrez Gene: HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11".
↑ "Research update from the MCM team (March 2024)". World Community Grid. 14 March 2024. Retrieved 21 May 2024.

Li KX, Smith RE, Krozowski ZS (1999). "Cloning and expression of a novel tissue specific 17beta-hydroxysteroid dehydrogenase". Endocrine Research. 24 (3–4): 663–7. doi:10.3109/07435809809032667. PMID 9888557.
Haeseleer F, Palczewski K (2000). "Short-chain dehydrogenases/Reductases in retina". Vertebrate Phototransduction and the Visual Cycle, Part B. Methods in Enzymology. Vol. 316. pp. 372–83. doi:10.1016/S0076-6879(00)16736-9. ISBN 978-0-12-182217-0. PMID 10800688.
Hartmann TB, Thiel D, Dummer R, Schadendorf D, Eichmüller S (February 2004). "SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma". The British Journal of Dermatology. 150 (2): 252–8. doi:10.1111/j.1365-2133.2004.05651.x. PMID 14996095. S2CID 42495130.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID 16303743.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198189 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029311 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11165019-5] Brereton P, Suzuki T, Sasano H, Li K, Duarte C, Obeyesekere V, Haeseleer F, Palczewski K, Smith I, Komesaroff P, Krozowski Z (January 2001). "Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung". Molecular and Cellular Endocrinology. 171 (1–2): 111–7. doi:10.1016/S0303-7207(00)00417-2. PMID 11165019. S2CID 54263651.

[pmid12697717-6] Chai Z, Brereton P, Suzuki T, Sasano H, Obeyesekere V, Escher G, Saffery R, Fuller P, Enriquez C, Krozowski Z (May 2003). "17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells". Endocrinology. 144 (5): 2084–91. doi: 10.1210/en.2002-221030 . PMID 12697717.

[pmid19027726-7] Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (March 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chemico-Biological Interactions. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744 . PMID 19027726.

[entrez-8] "Entrez Gene: HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11".

[9] "Research update from the MCM team (March 2024)". World Community Grid. 14 March 2024. Retrieved 21 May 2024.

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HSD17B11

Related Research Articles

References

Further reading