HSD17B12

HSD17B12
Identifiers
Aliases	HSD17B12 , KAR, SDR12C1, hydroxysteroid (17-beta) dehydrogenase 12, hydroxysteroid 17-beta dehydrogenase 12
External IDs	OMIM: 609574; MGI: 1926967; HomoloGene: 95094; GeneCards: HSD17B12; OMA:HSD17B12 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p11.2 Start 43,680,680 bp [1] End 43,856,617 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 E1 Start 93,863,034 bp [2] End 93,988,309 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell retinal pigment epithelium pancreatic ductal cell optic nerve pars reticulata inferior ganglion of vagus nerve cardia renal medulla spinal ganglia pars compacta Top expressed in skin of external ear brown adipose tissue transitional epithelium of urinary bladder cumulus cell tunica adventitia of aorta left lobe of liver ciliary body iris sciatic nerve lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heparin binding estradiol 17-beta-dehydrogenase activity oxidoreductase activity collagen binding fibronectin binding protein binding 3-oxo-lignoceroyl-CoA reductase activity 3-oxo-behenoyl-CoA reductase activity long-chain-3-hydroxyacyl-CoA dehydrogenase activity 3-oxo-arachidoyl-CoA reductase activity 3-oxo-cerotoyl-CoA reductase activity Cellular component integral component of membrane membrane endoplasmic reticulum endoplasmic reticulum membrane extracellular matrix Biological process lipid metabolism extracellular matrix organization long-chain fatty-acyl-CoA biosynthetic process positive regulation of cell-substrate adhesion fatty acid biosynthetic process estrogen biosynthetic process steroid biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51144 56348 Ensembl ENSG00000149084 ENSMUSG00000027195 UniProt Q53GQ0 O70503 RefSeq (mRNA) NM_016142 NM_019657 RefSeq (protein) NP_057226 NP_062631 Location (UCSC) Chr 11: 43.68 – 43.86 Mb Chr 2: 93.86 – 93.99 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Estradiol 17-beta-dehydrogenase 12 is an enzyme that in humans is encoded by the HSD17B12 gene. ^{[5] [6] [7]}

The enzyme 17-beta hydroxysteroid dehydrogenase-12 (HSD17B12) uses NADPH to reduce 3-ketoacyl-CoA to 3-hydroxyacyl-CoA during the second step of fatty acid elongation.[supplied by OMIM] ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000149084 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027195 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Moon YA, Horton JD (Feb 2003). "Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade". J Biol Chem. 278 (9): 7335–43. doi: 10.1074/jbc.M211684200 . PMID   12482854.
6. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC   2896744 . PMID   19027726.
7. "Entrez Gene: HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Gnatenko DV, Cupit LD, Huang EC, et al. (2005). "Platelets express steroidogenic 17beta-hydroxysteroid dehydrogenases. Distinct profiles predict the essential thrombocythemic phenotype". Thromb. Haemost. 94 (2): 412–21. doi:10.1160/TH05-01-0037. PMID   16113833. S2CID   257259321.
• Luu-The V, Tremblay P, Labrie F (2006). "Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women". Mol. Endocrinol. 20 (2): 437–43. doi: 10.1210/me.2005-0058 . PMID   16166196.
• Sakurai N, Miki Y, Suzuki T, et al. (2006). "Systemic distribution and tissue localizations of human 17beta-hydroxysteroid dehydrogenase type 12". J. Steroid Biochem. Mol. Biol. 99 (4–5): 174–81. doi:10.1016/j.jsbmb.2006.01.010. PMID   16621523. S2CID   22249124.