HTATIP2

HTATIP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BKA
Identifiers
Aliases	HTATIP2 , CC3, SDR44U1, TIP30, HIV-1 Tat interactive protein 2
External IDs	OMIM: 605628 MGI: 1859271 HomoloGene: 4676 GeneCards: HTATIP2
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.1 Start 20,363,685 bp [1] End 20,383,782 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 B4 Start 49,408,863 bp [2] End 49,423,723 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa duodenum islet of Langerhans sperm rectum monocyte pancreatic ductal cell vulva gums right adrenal gland Top expressed in epithelium of stomach duodenum left lobe of liver pyloric antrum mucous cell of stomach seminal vesicula olfactory epithelium esophagus seminiferous tubule lacrimal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity transcription coactivator activity protein binding Cellular component cytoplasm nuclear envelope membrane nucleus cytosol Biological process multicellular organism development regulation of transcription by RNA polymerase II cell differentiation viral process negative regulation of apoptotic process regulation of angiogenesis angiogenesis import into nucleus apoptotic process positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10553 53415 Ensembl ENSG00000109854 ENSMUSG00000039745 UniProt Q9BUP3 Q9Z2G9 RefSeq (mRNA) NM_006410 NM_001098520 NM_001098521 NM_001098522 NM_001098523 NM_001146049 NM_001146050 NM_001146052 NM_001146053 NM_016865 RefSeq (protein) NP_001091990 NP_001091991 NP_001091992 NP_001091993 NP_006401 NP_001139521 NP_001139522 NP_001139524 NP_001139525 NP_058561 Location (UCSC) Chr 11: 20.36 – 20.38 Mb Chr 7: 49.41 – 49.42 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Oxidoreductase HTATIP2 is an enzyme that in humans is encoded by the HTATIP2 gene. ^{[5] [6] [7] [8]} It may be a metastasis suppressor.

References

1. GRCh38: Ensembl release 89: ENSG00000109854 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039745 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Xiao H, Tao Y, Greenblatt J, Roeder RG (Apr 1998). "A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription". Proc Natl Acad Sci U S A. 95 (5): 2146–51. Bibcode:1998PNAS...95.2146X. doi: 10.1073/pnas.95.5.2146 . PMC   19278 . PMID   9482853.
6. Shtivelman E (Jun 1997). "A link between metastasis and resistance to apoptosis of variant small cell lung carcinoma". Oncogene. 14 (18): 2167–73. doi: 10.1038/sj.onc.1201059 . PMID   9174052.
7. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jörnvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC   2896744 . PMID   19027726.
8. "Entrez Gene: HTATIP2 HIV-1 Tat interactive protein 2, 30kDa".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Baker ME (1999). "TIP30, a cofactor for HIV-1 Tat-activated transcription, is homologous to short-chain dehydrogenases/reductases". Curr. Biol. 9 (13): R471. doi: 10.1016/S0960-9822(99)80297-8 . PMID   10395547. S2CID   7740085.
• Whitman S, Wang X, Shalaby R, Shtivelman E (2000). "Alternatively spliced products CC3 and TC3 have opposing effects on apoptosis". Mol. Cell. Biol. 20 (2): 583–93. doi:10.1128/MCB.20.2.583-593.2000. PMC   85138 . PMID   10611237.
• Xiao H, Palhan V, Yang Y, Roeder RG (2000). "TIP30 has an intrinsic kinase activity required for up-regulation of a subset of apoptotic genes". EMBO J. 19 (5): 956–63. doi:10.1093/emboj/19.5.956. PMC   305635 . PMID   10698937.
• Baker ME, Yan L, Pear MR (2000). "Three-dimensional model of human TIP30, a coactivator for HIV-1 Tat-activated transcription, and CC3, a protein associated with metastasis suppression". Cell. Mol. Life Sci. 57 (5): 851–8. doi: 10.1007/s000180050047 . PMID   10892349. S2CID   25141732.
• NicAmhlaoibh R, Shtivelman E (2001). "Metastasis suppressor CC3 inhibits angiogenic properties of tumor cells in vitro". Oncogene. 20 (2): 270–5. doi: 10.1038/sj.onc.1204075 . PMID   11313954.
• Ito M, Jiang C, Krumm K, Zhang X, Pecha J, Zhao J, Guo Y, Roeder RG, Xiao H (2004). "TIP30 deficiency increases susceptibility to tumorigenesis". Cancer Res. 63 (24): 8763–7. PMID   14695192.
• Jiang C, Ito M, Piening V, Bruck K, Roeder RG, Xiao H (2004). "TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription". J. Biol. Chem. 279 (26): 27781–9. doi: 10.1074/jbc.M401809200 . PMID   15073177.
• Tsutsumi S, Kamata N, Vokes TJ, Maruoka Y, Nakakuki K, Enomoto S, Omura K, Amagasa T, Nagayama M, Saito-Ohara F, Inazawa J, Moritani M, Yamaoka T, Inoue H, Itakura M (2004). "The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD)". Am. J. Hum. Genet. 74 (6): 1255–61. doi:10.1086/421527. PMC   1182089 . PMID   15124103.
• King FW, Shtivelman E (2004). "Inhibition of nuclear import by the proapoptotic protein CC3". Mol. Cell. Biol. 24 (16): 7091–101. doi:10.1128/MCB.24.16.7091-7101.2004. PMC   479715 . PMID   15282309.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Sun L, Feng S, Reséndiz JC, Lu X, Durante W, Kroll MH (2005). "Role of the Pyk2-MAP kinase-cPLA2 signaling pathway in shear-dependent platelet aggregation". Annals of Biomedical Engineering. 32 (9): 1193–201. doi:10.1114/B:ABME.0000039353.97347.28. PMID   15493507. S2CID   31410967.
• Shi M, Zhang X, Wang P, Zhang HW, Zhang BH, Wu MC (2005). "TIP30 regulates apoptosis-related genes in its apoptotic signal transduction pathway". World J. Gastroenterol. 11 (2): 221–7. doi: 10.3748/wjg.v11.i2.221 . PMC   4205406 . PMID   15633220.
• El Omari K, Bird LE, Nichols CE, Ren J, Stammers DK (2005). "Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor". J. Biol. Chem. 280 (18): 18229–36. doi: 10.1074/jbc.M501113200 . PMID   15728189.
• Caldwell RL, Lane KB, Shepherd VL (2006). "HIV-1 Tat interaction with cyclin T1 represses mannose receptor and the bone morphogenetic protein receptor-2 transcription". Arch. Biochem. Biophys. 449 (1–2): 27–33. doi:10.1016/j.abb.2006.02.020. PMID   16615932.