Content | |
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Description | Chemical pharmacology and toxicology data |
Data types captured |
|
Organisms | Humans & other animals |
Contact | |
Research center | NCBI |
Primary citation | Fonger (1995) [2] Fonger, et al (2014) [3] |
Access | |
Website | www |
Miscellaneous | |
License | Public domain |
Data release frequency | Weekly |
Curation policy | Peer-reviewed by the Scientific Review Panel |
The Hazardous Substances Data Bank (HSDB) was a toxicology database on the U.S. National Library of Medicine's (NLM) Toxicology Data Network (TOXNET). [2] [3] It focused on the toxicology of potentially hazardous chemicals, and included information on human exposure, industrial hygiene, emergency handling procedures, environmental fate, regulatory requirements, and related areas. All data were referenced and derived from a core set of books, government documents, technical reports, and selected primary journal literature. Prior to 2020, all entries were peer-reviewed by a Scientific Review Panel (SRP), members of which represented a spectrum of professions and interests. Last Chairs of the SRP are Dr. Marcel J. Cassavant, MD, Toxicology Group, and Dr. Roland Everett Langford, PhD, Environmental Fate Group. The SRP was terminated due to budget cuts and realignment of the NLM.
The HSDB was organized into individual chemical records, and contained over 5000 such records. [4] It was accessible free of charge via TOXNET. Users could search by chemical or other name, chemical name fragment, CAS registry number and/or subject terms. Recent additions included radioactive materials and certain mixtures, like crude oil and oil dispersants as well as animal toxins. As of November 2014 [update] , there were approximately 5,600 chemical specific HSDB records available. [3]
The Toxicology Data Network (TOXNET) was a group of databases hosted on the National Library of Medicine (NLM) website that covered "chemicals and drugs, diseases and the environment, environmental health, occupational safety and health, poisoning, risk assessment and regulations, and toxicology". [5] TOXNET was managed by the NLM's Toxicology and Environmental Health Information Program (TEHIP) in the Division of Specialized Information Services (SIS). [5]
The TOXNET databases included: [6]
In toxicology, the median lethal dose, LD50 (abbreviation for "lethal dose, 50%"), LC50 (lethal concentration, 50%) or LCt50 is a toxic unit that measures the lethal dose of a given substance. The value of LD50 for a substance is the dose required to kill half the members of a tested population after a specified test duration. LD50 figures are frequently used as a general indicator of a substance's acute toxicity. A lower LD50 is indicative of higher toxicity.
A toxin is a naturally occurring organic poison produced by metabolic activities of living cells or organisms. They occur especially as proteins, often conjugated. The term was first used by organic chemist Ludwig Brieger (1849–1919) and is derived from the word "toxic".
Toxicology is a scientific discipline, overlapping with biology, chemistry, pharmacology, and medicine, that involves the study of the adverse effects of chemical substances on living organisms and the practice of diagnosing and treating exposures to toxins and toxicants. The relationship between dose and its effects on the exposed organism is of high significance in toxicology. Factors that influence chemical toxicity include the dosage, duration of exposure, route of exposure, species, age, sex, and environment. Toxicologists are experts on poisons and poisoning. There is a movement for evidence-based toxicology as part of the larger movement towards evidence-based practices. Toxicology is currently contributing to the field of cancer research, since some toxins can be used as drugs for killing tumor cells. One prime example of this is ribosome-inactivating proteins, tested in the treatment of leukemia.
Hazardous waste is waste that has substantial or potential threats to public health or the environment. Hazardous waste is a type of dangerous goods. They usually have one or more of the following hazardous traits: ignitability, reactivity, corrosivity, toxicity. Listed hazardous wastes are materials specifically listed by regulatory authorities as hazardous wastes which are from non-specific sources, specific sources, or discarded chemical products. Hazardous wastes may be found in different physical states such as gaseous, liquids, or solids. A hazardous waste is a special type of waste because it cannot be disposed of by common means like other by-products of our everyday lives. Depending on the physical state of the waste, treatment and solidification processes might be required.
Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. Toxicity can refer to the effect on a whole organism, such as an animal, bacterium, or plant, as well as the effect on a substructure of the organism, such as a cell (cytotoxicity) or an organ such as the liver (hepatotoxicity). Sometimes the word is more or less synonymous with poisoning in everyday usage.
Toxic waste is any unwanted material in all forms that can cause harm. Mostly generated by industry, consumer products like televisions, computers, and phones contain toxic chemicals that can pollute the air and contaminate soil and water. Disposing of such waste is a major public health issue.
Environmental health is the branch of public health concerned with all aspects of the natural and built environment affecting human health. In order to effectively control factors that may affect health, the requirements that must be met in order to create a healthy environment must be determined. The major sub-disciplines of environmental health are environmental science, toxicology, environmental epidemiology, and environmental and occupational medicine.
The Agency for Toxic Substances and Disease Registry (ATSDR) is a federal public health agency within the United States Department of Health and Human Services. The agency focuses on minimizing human health risks associated with exposure to hazardous substances. It works closely with other federal, state, and local agencies; tribal governments; local communities; and healthcare providers. Its mission is to "Serve the public through responsive public health actions to promote healthy and safe environments and prevent harmful exposures." ATSDR was created as an advisory, nonregulatory agency by the Superfund legislation and was formally organized in 1985.
Superfund is a United States federal environmental remediation program established by the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). The program is administered by the Environmental Protection Agency (EPA). The program is designed to investigate and clean up sites contaminated with hazardous substances. Sites managed under this program are referred to as Superfund sites. There are 40,000 federal Superfund sites across the country, and approximately 1,300 of those sites have been listed on the National Priorities List (NPL). Sites on the NPL are considered the most highly contaminated and undergo longer-term remedial investigation and remedial action (cleanups).
Ethyl carbamate (also called urethane) is an organic compound with the formula CH3CH2OC(O)NH2. It is an ester of carbamic acid and a white solid. Despite its name, it is not a component of polyurethanes. Because it is a carcinogen, it is rarely used, but naturally forms in low quantities in many types of fermented foods and drinks.
Fenthion is an organothiophosphate insecticide, avicide, and acaricide. Like most other organophosphates, its mode of action is via cholinesterase inhibition. Due to its relatively low toxicity towards humans and mammals, fenthion is listed as moderately toxic compound in U.S. Environmental Protection Agency and World Health Organization toxicity class.
Monosodium methyl arsenate (MSMA) is an arsenic-based herbicide. It is an organo-arsenate; less toxic than the inorganic form of arsenates. However, the EPA states that all forms of arsenic are a serious risk to human health and the United States' Agency for Toxic Substances and Disease Registry ranked arsenic as number 1 in its 2001 Priority List of Hazardous Substances at Superfund sites.
Dichlorodiphenyldichloroethane (DDD) is an organochlorine insecticide that is slightly irritating to the skin. DDD is a metabolite of DDT. DDD is colorless and crystalline; it is closely related chemically and is similar in properties to DDT, but it is considered to be less toxic to animals than DDT. The molecular formula for DDD is (ClC6H4)2CHCHCl2 or C14H10Cl4, whereas the formula for DDT is (ClC6H4)2CHCCl3 or C14H9Cl5.
TOXMAP was a geographic information system (GIS) from the United States National Library of Medicine (NLM) that was deprecated on December 16, 2019. The application used maps of the United States to help users explore data from the United States Environmental Protection Agency's (EPA) Toxics Release Inventory (TRI) and Superfund programs with visual projections and maps.
The Risk Information Exchange (RiskIE) is an Internet database created in 2007 by Toxicology Excellence for Risk Assessment (TERA). The database provides in-progress and recently completed chemical risk assessments. As a potential global tracking system, RiskIE might enable scientists to keep abreast of current chemical evaluations, identify opportunities for collaborations, and decide how to efficiently proceed with chemical registration, such as that of the European Union's Registration, Evaluation, Authorisation, and Restriction of Chemicals (REACH). According to Wullenweber et al. (2008), whereas risk databases have historically managed the risk data of a single country/organization, RiskIE offers a centralized database open to all. The United Nations Office for Disaster Risk Reduction also uses this data aggregator. It claims that 52 countries are utilizing it as of 2022.
To protect the environment from the adverse effects of pollution, many nations worldwide have enacted legislation to regulate various types of pollution as well as to mitigate the adverse effects of pollution. At the local level, regulation usually is supervised by environmental agencies or the broader public health system. Different jurisdictions often have different levels regulation and policy choices about pollution. Historically, polluters will lobby governments in less economically developed areas or countries to maintain lax regulation in order to protect industrialisation at the cost of human and environmental health.
The Environmental Mutagenesis and Genomics Society (EMGS) is a scientific society "for the promotion of critical scientific knowledge and research into the causes and consequences of damage to the genome and epigenome in order to inform and support national and international efforts to ensure a healthy, sustainable environment for future generations."
Carbophenothion also known as Stauffer R 1303 as for the manufacturer, Stauffer Chemical, is an organophosphorus chemical compound. It was used as a pesticide for citrus fruits under the name of Trithion. Carbophenothion was used as an insecticide and acaricide. Although not used anymore it is still a restricted use pesticide in the United States. The chemical is identified in the US as an extremely hazardous substance according to the Emergency Planning and Community Right-to-Know Act.
Methacrolein diacetate is a chemical compound with the molecular formula C8H12O4 and a molecular weight of 172.17848. It is a colorless liquid. It is listed as an extremely hazardous substance by the Emergency Planning and Community Right-to-Know Act, and the National Institute of Health identifies it as "an irritant of the eyes, skin, and respiratory tract."
Triazofos is a chemical compound used in acaricides, insecticides, and nematicides.
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