Hazardous Substances Data Bank

Last updated

TOXNET: Hazardous Substances Data Bank
Content
DescriptionChemical pharmacology and toxicology data
Data types
captured
  • 5000+ potentially hazardous chemicals
  • human exposure
  • pharmacology
  • metabolism
  • medications excreted in breastmilk [1]
  • industrial hygiene
  • emergency handling
  • environmental fate
  • regulatory requirements
  • related areas
Organisms Humans & other animals
Contact
Research center NCBI
Primary citationFonger (1995) [2]
Fonger, et al (2014) [3]
Access
Website www.nlm.nih.gov/toxnet/index.html
Miscellaneous
License Public domain
Data release
frequency
Weekly
Curation policyPeer-reviewed by the Scientific Review Panel

The Hazardous Substances Data Bank (HSDB) was a toxicology database on the U.S. National Library of Medicine's (NLM) Toxicology Data Network (TOXNET). [2] [3] It focused on the toxicology of potentially hazardous chemicals, and included information on human exposure, industrial hygiene, emergency handling procedures, environmental fate, regulatory requirements, and related areas. All data were referenced and derived from a core set of books, government documents, technical reports, and selected primary journal literature. Prior to 2020, all entries were peer-reviewed by a Scientific Review Panel (SRP), members of which represented a spectrum of professions and interests. Last Chairs of the SRP are Dr. Marcel J. Cassavant, MD, Toxicology Group, and Dr. Roland Everett Langford, PhD, Environmental Fate Group. The SRP was terminated due to budget cuts and realignment of the NLM.

Contents

The HSDB was organized into individual chemical records, and contained over 5000 such records. [4] It was accessible free of charge via TOXNET. Users could search by chemical or other name, chemical name fragment, CAS registry number and/or subject terms. Recent additions included radioactive materials and certain mixtures, like crude oil and oil dispersants as well as animal toxins. As of November 2014, there were approximately 5,600 chemical specific HSDB records available. [3]

TOXNET databases

The Toxicology Data Network (TOXNET) was a group of databases hosted on the National Library of Medicine (NLM) website that covered "chemicals and drugs, diseases and the environment, environmental health, occupational safety and health, poisoning, risk assessment and regulations, and toxicology". [5] TOXNET was managed by the NLM's Toxicology and Environmental Health Information Program (TEHIP) in the Division of Specialized Information Services (SIS). [5]

The TOXNET databases included: [6]

  1. HSDB: Hazardous Substances Data Bank
    • Peer-reviewed toxicology data for over 5,000 hazardous chemicals
  2. TOXLINE
    • 4 million references to literature on biochemical, pharmacological, physiological, and toxicological effects of drugs and other chemicals
  3. ChemIDplus
    • Dictionary of over 400,000 chemicals (names, synonyms, and structures)
  4. LactMed: Drugs and Lactation Database
    • Drugs and other chemicals to which breastfeeding mothers may be exposed
  5. DART: Developmental and Reproductive Toxicology Database
    • References to developmental and reproductive toxicology literature
  6. TOXMAP
    • Environmental Health Maps provides searchable, interactive maps of EPA TRI and Superfund data, plus US Census and NCI health data
  7. TRI: Toxics Release Inventory
    • Annual environmental releases of over 600 toxic chemicals by U.S. facilities
  8. CTD: Comparative Toxicogenomics Database
    • Access to scientific data describing relationships between chemicals, genes and human diseases
  9. Household Products Database
    • Potential health effects of chemicals in more than 10,000 common household products
  10. Haz-Map
    • Links jobs and hazardous tasks with occupational diseases and their symptoms
  11. IRIS: Integrated Risk Information System
    • Hazard identification and dose-response assessment for over 500 chemicals
  12. ITER: International Toxicity Estimates for Risk
    • Risk information for over 600 chemicals from authoritative groups worldwide
  13. ALTBIB
    • Resources on Alternatives to the Use of Live Vertebrates in Biomedical Research and Testing

Related Research Articles

In toxicology, the median lethal dose, LD50 (abbreviation for "lethal dose, 50%"), LC50 (lethal concentration, 50%) or LCt50 is a toxic unit that measures the lethal dose of a given substance. The value of LD50 for a substance is the dose required to kill half the members of a tested population after a specified test duration. LD50 figures are frequently used as a general indicator of a substance's acute toxicity. A lower LD50 is indicative of higher toxicity.

<span class="mw-page-title-main">Toxin</span> Naturally occurring organic poison

A toxin is a naturally occurring organic poison produced by metabolic activities of living cells or organisms. They occur especially as proteins, often conjugated. The term was first used by organic chemist Ludwig Brieger (1849–1919) and is derived from the word "toxic".

<span class="mw-page-title-main">Toxicology</span> Study of substances harmful to living organisms

Toxicology is a scientific discipline, overlapping with biology, chemistry, pharmacology, and medicine, that involves the study of the adverse effects of chemical substances on living organisms and the practice of diagnosing and treating exposures to toxins and toxicants. The relationship between dose and its effects on the exposed organism is of high significance in toxicology. Factors that influence chemical toxicity include the dosage, duration of exposure, route of exposure, species, age, sex, and environment. Toxicologists are experts on poisons and poisoning. There is a movement for evidence-based toxicology as part of the larger movement towards evidence-based practices. Toxicology is currently contributing to the field of cancer research, since some toxins can be used as drugs for killing tumor cells. One prime example of this is ribosome-inactivating proteins, tested in the treatment of leukemia.

<span class="mw-page-title-main">Hazardous waste</span> Ignitable, reactive, corrosive and/or toxic unwanted or unusable materials

Hazardous waste is waste that has substantial or potential threats to public health or the environment. Hazardous waste is a type of dangerous goods. They usually have one or more of the following hazardous traits: ignitability, reactivity, corrosivity, toxicity. Listed hazardous wastes are materials specifically listed by regulatory authorities as hazardous wastes which are from non-specific sources, specific sources, or discarded chemical products. Hazardous wastes may be found in different physical states such as gaseous, liquids, or solids. A hazardous waste is a special type of waste because it cannot be disposed of by common means like other by-products of our everyday lives. Depending on the physical state of the waste, treatment and solidification processes might be required.

<span class="mw-page-title-main">Toxicity</span> Degree of harmfulness of substances

Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. Toxicity can refer to the effect on a whole organism, such as an animal, bacterium, or plant, as well as the effect on a substructure of the organism, such as a cell (cytotoxicity) or an organ such as the liver (hepatotoxicity). Sometimes the word is more or less synonymous with poisoning in everyday usage.

<span class="mw-page-title-main">Toxic waste</span> Any unwanted material which can cause harm

Toxic waste is any unwanted material in all forms that can cause harm. Mostly generated by industry, consumer products like televisions, computers, and phones contain toxic chemicals that can pollute the air and contaminate soil and water. Disposing of such waste is a major public health issue.

<span class="mw-page-title-main">Environmental health</span> Public health branch focused on environmental impacts on human health

Environmental health is the branch of public health concerned with all aspects of the natural and built environment affecting human health. In order to effectively control factors that may affect health, the requirements that must be met in order to create a healthy environment must be determined. The major sub-disciplines of environmental health are environmental science, toxicology, environmental epidemiology, and environmental and occupational medicine.

<span class="mw-page-title-main">Agency for Toxic Substances and Disease Registry</span> US federal agency

The Agency for Toxic Substances and Disease Registry (ATSDR) is a federal public health agency within the United States Department of Health and Human Services. The agency focuses on minimizing human health risks associated with exposure to hazardous substances. It works closely with other federal, state, and local agencies; tribal governments; local communities; and healthcare providers. Its mission is to "Serve the public through responsive public health actions to promote healthy and safe environments and prevent harmful exposures." ATSDR was created as an advisory, nonregulatory agency by the Superfund legislation and was formally organized in 1985.

<span class="mw-page-title-main">Superfund</span> US federal program to investigate / clean up sites contaminated with hazardous substances

Superfund is a United States federal environmental remediation program established by the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). The program is administered by the Environmental Protection Agency (EPA). The program is designed to investigate and clean up sites contaminated with hazardous substances. Sites managed under this program are referred to as Superfund sites. There are 40,000 federal Superfund sites across the country, and approximately 1,300 of those sites have been listed on the National Priorities List (NPL). Sites on the NPL are considered the most highly contaminated and undergo longer-term remedial investigation and remedial action (cleanups).

<span class="mw-page-title-main">Ethyl carbamate</span> Chemical compound

Ethyl carbamate (also called urethane) is an organic compound with the formula CH3CH2OC(O)NH2. It is an ester of carbamic acid and a white solid. Despite its name, it is not a component of polyurethanes. Because it is a carcinogen, it is rarely used, but naturally forms in low quantities in many types of fermented foods and drinks.

<span class="mw-page-title-main">Fenthion</span> Chemical compound

Fenthion is an organothiophosphate insecticide, avicide, and acaricide. Like most other organophosphates, its mode of action is via cholinesterase inhibition. Due to its relatively low toxicity towards humans and mammals, fenthion is listed as moderately toxic compound in U.S. Environmental Protection Agency and World Health Organization toxicity class.

<span class="mw-page-title-main">Monosodium methyl arsonate</span> Arsenic-based herbicide

Monosodium methyl arsenate (MSMA) is an arsenic-based herbicide. It is an organo-arsenate; less toxic than the inorganic form of arsenates. However, the EPA states that all forms of arsenic are a serious risk to human health and the United States' Agency for Toxic Substances and Disease Registry ranked arsenic as number 1 in its 2001 Priority List of Hazardous Substances at Superfund sites.

<span class="mw-page-title-main">Dichlorodiphenyldichloroethane</span> Chemical compound

Dichlorodiphenyldichloroethane (DDD) is an organochlorine insecticide that is slightly irritating to the skin. DDD is a metabolite of DDT. DDD is colorless and crystalline; it is closely related chemically and is similar in properties to DDT, but it is considered to be less toxic to animals than DDT. The molecular formula for DDD is (ClC6H4)2CHCHCl2 or C14H10Cl4, whereas the formula for DDT is (ClC6H4)2CHCCl3 or C14H9Cl5.

TOXMAP was a geographic information system (GIS) from the United States National Library of Medicine (NLM) that was deprecated on December 16, 2019. The application used maps of the United States to help users explore data from the United States Environmental Protection Agency's (EPA) Toxics Release Inventory (TRI) and Superfund programs with visual projections and maps.

The Risk Information Exchange (RiskIE) is an Internet database created in 2007 by Toxicology Excellence for Risk Assessment (TERA). The database provides in-progress and recently completed chemical risk assessments. As a potential global tracking system, RiskIE might enable scientists to keep abreast of current chemical evaluations, identify opportunities for collaborations, and decide how to efficiently proceed with chemical registration, such as that of the European Union's Registration, Evaluation, Authorisation, and Restriction of Chemicals (REACH). According to Wullenweber et al. (2008), whereas risk databases have historically managed the risk data of a single country/organization, RiskIE offers a centralized database open to all. The United Nations Office for Disaster Risk Reduction also uses this data aggregator. It claims that 52 countries are utilizing it as of 2022.

To protect the environment from the adverse effects of pollution, many nations worldwide have enacted legislation to regulate various types of pollution as well as to mitigate the adverse effects of pollution. At the local level, regulation usually is supervised by environmental agencies or the broader public health system. Different jurisdictions often have different levels regulation and policy choices about pollution. Historically, polluters will lobby governments in less economically developed areas or countries to maintain lax regulation in order to protect industrialisation at the cost of human and environmental health.

The Environmental Mutagenesis and Genomics Society (EMGS) is a scientific society "for the promotion of critical scientific knowledge and research into the causes and consequences of damage to the genome and epigenome in order to inform and support national and international efforts to ensure a healthy, sustainable environment for future generations."

<span class="mw-page-title-main">Carbophenothion</span> Chemical compound

Carbophenothion also known as Stauffer R 1303 as for the manufacturer, Stauffer Chemical, is an organophosphorus chemical compound. It was used as a pesticide for citrus fruits under the name of Trithion. Carbophenothion was used as an insecticide and acaricide. Although not used anymore it is still a restricted use pesticide in the United States. The chemical is identified in the US as an extremely hazardous substance according to the Emergency Planning and Community Right-to-Know Act.

<span class="mw-page-title-main">Methacrolein diacetate</span> Chemical compound

Methacrolein diacetate is a chemical compound with the molecular formula C8H12O4 and a molecular weight of 172.17848. It is a colorless liquid. It is listed as an extremely hazardous substance by the Emergency Planning and Community Right-to-Know Act, and the National Institute of Health identifies it as "an irritant of the eyes, skin, and respiratory tract."

<span class="mw-page-title-main">Triazofos</span> Chemical compound

Triazofos is a chemical compound used in acaricides, insecticides, and nematicides.

References

  1. Drugs and Lactation Database (LactMed). National Library of Medicine (US). 2006.{{cite book}}: |website= ignored (help)PD-icon.svg This article incorporates text from this source, which is in the public domain.
  2. 1 2 Fonger GC (1995). "Hazardous substances data bank (HSDB) as a source of environmental fate information on chemicals". Toxicology. 103 (2): 137–45. doi:10.1016/0300-483x(95)03145-6. PMID   8545846.
  3. 1 2 3 Fonger GC, Hakkinen P, Jordan S, Publicker S (2014). "The National Library of Medicine's (NLM) Hazardous Substances Data Bank (HSDB): background, recent enhancements and future plans". Toxicology. 325: 209–16. doi:10.1016/j.tox.2014.09.003. PMC   4195797 . PMID   25223694.
  4. Fact Sheet – Hazardous Substances Data Bank (HSDB), National Library of Medicine, September 2006, retrieved 29 August 2009
  5. 1 2 "Fact Sheet – TOXNET®: Toxicology Data Network". United States National Library of Medicine. Toxicology Data Network. Retrieved 4 January 2018.
  6. "TOXNET Databases". United States National Library of Medicine. Toxicology Data Network. Retrieved 4 January 2018.