Hepatoprotection

Hepatoprotection or antihepatotoxicity is the ability of a chemical substance to prevent damage to the liver. This is opposite to hepatotoxicity.

Hepatoprotective molecules used in emergency medicine

• Acetylcysteine is considered the hepatoprotective drug of choice when treating an overdose of acetaminophen/paracetamol. ^[1]
• Silymarin is given intravenously to treat poisoning from Amanita mushrooms according to the Santa Cruz protocol devised by Dr Todd Mitchell at UCSC.

Herbs with potentially hepatoprotective constituents

• Astragalus membranaceus ^[2]
• Curcuma longa ^[3]
• Brassica ^[4]
• Silybum marianum , from which silymarin is derived
• Andrographis paniculata ^[5]

References

1. "Archived copy" (PDF). Archived from the original (PDF) on 2021-06-23. Retrieved 2019-11-07.
2. Chien, CF; Wu, YT; Tsai, TH (Jan 2011). "Biological analysis of herbal medicines used for the treatment of liver diseases". Biomedical Chromatography. 25 (1–2): 21–38. doi:10.1002/bmc.1568. PMID   21204110.
3. Ghosh, N; Ghosh, R; Mandal, V; Mandal, SC (Sep 2011). "Recent advances in herbal medicine for treatment of liver diseases". Pharmaceutical Biology. 49 (9): 970–88. doi: 10.3109/13880209.2011.558515 . PMID   21595500.
4. Steinkellner, H; Rabot, S; Freywald, C; Nobis, E; Scharf, G; Chabicovsky, M; Knasmüller, S; Kassie, F (Sep 1, 2001). "Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens". Mutation Research. 480–481: 285–97. Bibcode:2001MRFMM.480..285S. doi:10.1016/S0027-5107(01)00188-9. PMID   11506821.
5. Andrographis paniculata http://www.stuartxchange.com/Sinta.html