Herbert M. Sauro

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Herbert M. Sauro
BornJuly 1960 (age 64)
Dyfed, Wales
NationalityBritish, USA
Alma mater
Known for metabolic control analysis, metabolic regulation, SBML
Scientific career
Fields Biochemistry, Bioengineering, systems biology
Institutions
Thesis Control analysis and simulation of metabolism  (1986)
Academic advisors David Fell

Herbert M. Sauro (born 19 July 1960) is a Welsh biochemist who works in the field of metabolic control analysis and systems biology.

Contents

Early and education

Sauro grew up in the village of Llangolman in Pembrokeshire and attended the Welsh comprehensive school Ysgol y Preseli. [1]

After obtaining a B.Sc. in biochemistry with microbiology at the University of Kent Canterbury and an M.Sc. in biological computing at the University of York, Sauro moved to Oxford Brookes University for his Ph.D. (1986) under the direction of David Fell, for a thesis entitled Control analysis and simulation of metabolism, work that led to several publications, including one in which new relationships between elasticities and control coefficients were described. [2] Subsequently he obtained a teaching degree at the University of Aberystwyth.

Research

Sauro carried out post-doctoral research at the University of Edinburgh in association with Henrik Kacser, when he worked on time-dependent systems [3] and enzyme-enzyme interactions. [4] [5]

While a student at Oxford Brookes Sauro wrote a program called SCAMP for modelling metabolic systems, [6] later developed as Jarnac [7] and incorporated in his Systems Biology Workbench. [8]

Together with Hamid Bolouri, Andrew Finney and Michael Hucka he was a member of the development team for the creation of SBML (the Systems Biology Mark-up language), [9] which has become a major influence on the subject. [10]

In 2018, Sauro's research group published Tellurium, a Python-based modeling environment with applications in system analysis and synthetic biology. [11]

Books

Sauro is the author of books on metabolic control analysis, [12] enzyme kinetics, [13] and Laplace transforms. [14]

Career

After some years, first at Caltech (2000-2005), then at the Keck Graduate Institute in Claremont, California (2004-2007), Sauro moved to the University of Washington as an Associate professor in the department of Bioengineering in 2007. [15] [16] In 2013 he earned the University of Washington College of Engineering, Community of Innovators Awards, Faculty Innovator: Teaching & Learning. [17]

He is currently the director of the NIH Center for Reproducible Biomedical Modeling. [18]

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References

  1. ↑ ORCID   0000-0002-3659-6817
  2. ↑ Fell, D A; Sauro, H M (1985). "Metabolic control and its analysis: additional relationships between elasticities and control coefficients". Eur. J. Biochem. 148 (3): 555–561. doi: 10.1111/j.1432-1033.1985.tb08876.x . PMID   3996393.
  3. ↑ Acerenza, L; Sauro, H M; Kacser, H (1989). "Control analysis of time-dependent metabolic systems". J. Theor. Biol. 137 (4): 423–444. Bibcode:1989JThBi.137..423A. doi:10.1016/S0022-5193(89)80038-4. PMID   2626059.
  4. ↑ Kacser, H; Sauro, H M; Acerenza, L (1990). "Enzyme-enzyme interactions and control analysis. 1. the case of nonadditivity - monomer-oligomer associations". Eur. J. Biochem. 187 (3): 481–491. doi: 10.1111/j.1432-1033.1990.tb15329.x . PMID   2406132.
  5. ↑ Sauro, H M; Kacser, H (1990). "Enzyme-enzyme interactions and control analysis. 2. The case of nonindependence - heterologous association". Eur. J. Biochem. 187 (3): 493–500. doi: 10.1111/j.1432-1033.1990.tb15330.x . PMID   2406133.
  6. ↑ Sauro, H M (1993). "SCAMP: a general-purpose simulator and metabolic control analysis programs". Comput. Appl. Biosci. 9 (4): 441–450. doi:10.1093/bioinformatics/9.4.441. PMID   8402211.
  7. ↑ Sauro, H M (2000). "Jarnac: a system for interactive metabolic analysis". In Hofmeyr, J.-H.S.; Rohwer, J. M; Snoep, J. L (eds.). Animating the Cellular Map. Stellenbosch University Press. pp. 221–228. ISBN   0-7972-0776-7.
  8. ↑ Wellock, C; Chickarmane, V; Sauro, H M (2005). "The SBW-MATLAB Interface". Bioinformatics. 21 (6): 823–824. doi:10.1093/bioinformatics/bti110. PMID   15531613.
  9. ↑ Hucka, M.; Finney, A.; Sauro, H. M.; Bolouri, H.; Doyle, J. C.; Kitano, H.; Arkin, A. P.; Bornstein, B. J.; Bray, D; Cornish-Bowden, A.; Cuellar, A. A.; Dronov, S.; Gilles, E.D.; Ginkel, M; Gor, V.; Goryanin, I.I.; Hedley, W.J.; Hodgman, T. C.; Hofmeyr, J.-H.; Hunter, P. J.; Juty, N. S.; Kasberger, J. L.; Kremling, A.; Kummer, U.; Le Novère, N.; Loew, L. M.; Lucio, D.; Mendes, P.; Minch, E.; Mjolsness, E.D.; Nakayama, Y.; Nelson, M.R.; Nielsen, P. F.; Sakurada, T.; Schaff, J. C.; Shapiro, B.E.; Shimizu, T. S.; Spence, H. D.; Stelling, J.; Takahashi, K.; Tomita, M.; Wagner, J.; Wang, J. (2003). "The systems biology markup language (SBML): A medium for representation and exchange of biochemical network models". Bioinformatics. 19 (4): 524–531. CiteSeerX   10.1.1.562.1085 . doi: 10.1093/bioinformatics/btg015 . PMID   12611808.
  10. ↑ More than 3800 citations as of late 2024.
  11. ↑ Choi, Kiri; Medley, J. Kyle; König, Matthias; Stocking, Kaylene; Smith, Lucian; Gu, Stanley; Sauro, Herbert M. (July 2018). "Tellurium: An extensible python-based modeling environment for systems and synthetic biology". BioSystems. 171: 74–79. doi:10.1016/j.biosystems.2018.07.006. ISSN   1872-8324. PMC   6108935 . PMID   30053414.
  12. ↑ Sauro, H M (2018). Systems Biology: An Introduction to Metabolic Control Analysis (2nd ed.). Ambrosius. ISBN   978-0982477366.
  13. ↑ Sauro, H M (2023). Enzyme Kinetics for Systems Biology (2nd ed.). Ambrosius Publishing. ISBN   978-0982477335.
  14. ↑ Sauro, H M (2021). The Little Book of Laplace Transforms. Ambrosius Publishing. ISBN   978-1732548619.
  15. ↑ https://depts.washington.edu/bpsd/people/faculty/sauro/
  16. ↑ "Herbert M Sauro". ResearchGate. 14 March 2023. Retrieved 14 March 2023.
  17. ↑ "Past award recipients". UW College of Engineering. 25 June 2009. Retrieved 15 March 2023.
  18. ↑ "Center for Reproducible Biomedical Modeling". Center for Reproducible Biomedical Modeling.
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