Houghton Poultry Research Station | |
---|---|
![]() The entrance in March 2009 | |
Former names | Houghton Laboratory |
General information | |
Type | Agricultural research institute |
Address | Houghton, Cambridgeshire PE17 2DA |
Coordinates | 52°20′02″N0°06′00″W / 52.334°N 0.1°W |
Elevation | 15 m (49 ft) |
Completed | 1948 |
Inaugurated | 1948 |
Demolished | 1992 |
The Houghton Poultry Research Station was a poultry disease research station in northern Cambridgeshire.
By the 1970s, the site was the largest centre for poultry disease in the world.
Houghton Poultry Research Station was founded by the UK Animal Health Trust in 1948 as one of “a group of research stations devoted to the study of problems connected with farm livestock, each devoted to a single species but catering as a group for the needs of similar livestock such as goats, rabbits poultry and pigeons, as well as those of larger farm animals” [1] Dr Robert Fraser Gordon, a successful research worker and champion of the UK poultry industry, was appointed as the first director. He established what was to become a world-renowned centre for the study of infectious diseases of poultry from two ex-prisoner-war huts in the grounds of Houghton Grange in Huntingdonshire, near Cambridge. It was government-run from 1956. On the board was Emmanuel Amoroso, [2] Sir Kenneth Mather (vice-chancellor from 1965 to 1971 of the University of Southampton) and Trevor Stamp, 3rd Baron Stamp. The virologist Prof Peter Wildy was a chairman of the site.
The first programme included work on contemporary scourges of the UK poultry industry: salmonellosis, coccidiosis, fowl paralysis (as Marek's disease was then called) and virus diseases. Fowl pest (Newcastle disease) was not included as disease control facilities were inadequate. By 1949 new purpose-built laboratories had been erected and staff at the research station began their work. At the time fowl paralysis was a major problem of developing poultry industries around the world. For instance, in 1947 of the chickens over 8 weeks of age submitted for post mortem to the UK Central Veterinary Laboratories 14.2% had the disease and by 1949 this figure reached 20.4%. The problem was compounded as chickens with fowl paralysis (Marek's disease) had visceral lymphoma and this was confused with lymphoid leukosis. The two diseases, with completely different aetiologies, were included together under the general term ‘Avian Leukosis Complex’ leading to much confusion for diagnosticians and pathologists. Throughout the 1950s debate raged over the causes of different syndromes within the Avian Leukosis Complex, if it was transmitted vertically or by contact and if it could only be controlled by selective breeding, as recommended by some researchers at Cornell University. There was some hope for development of a diagnostic test; however, this proved a false dawn and reliable diagnostic tests were developed much later. Even as early as 1949, there was talk of the developing a vaccine.
Facilities for working on infectious diseases at Houghton in the 1950s were primitive but plans were ambitious, even to the extent of developing a mobile laboratory to house a ‘flying squad’ to investigate disease outbreaks on farms. Experimental facilities improved as birds began to be kept in isolation in purpose-built facilities. In addition, new permanent laboratories were built onto Houghton Grange, which provided the centre for administration and a library.
In 1959 Peter Biggs was employed to head the Leucosis Experimental Unit (LEU) devoted to unravelling the problems of lymphoid leukosis and fowl paralysis and ambitious plans were set in train for purpose-built complex of isolation laboratories and the production of disease-free chickens from another isolation unit built at Boxworth, some 8 miles away.
1961 saw the culmination of many years of confusion, when Biggs [3] and Campbell [4] proposed that the leukosis complex and fowl paralysis be separately classified. At the First World's Poultry Science Conference in Utrecht, Netherlands it was agreed that fowl paralysis be called Marek's disease as a tribute to József Marek who had provided the first published description [5]
In the 1960s LEU team was joined by a number of very able researchers including Tony Churchill and Jim (L.N.) Payne. This proved a very productive period for research on Marek's disease with collaborations, and friendly rivalry, between laboratories on both sides of the Atlantic. In 1967 the investment at Houghton paid dividends when the causative agent of Marek's disease, a highly cell-associated lymphotropic herpesvirus, was identified. [6] This was hailed by the press as a major breakthrough, which had implications for the study of human as well as animal tumour immunology. Although the causative virus was now identified there was still no means of prevention and the threat from acute Marek's disease assumed huge proportions with half of the birds succumbing in some flocks and losses in excess of 25% being frequent. Poultry diseases including Marek's were costing the industry a staggering 20% of annual farm income in 1969. At the time selecting for genetic resistance to Marek's disease was the only means of defence.Techniques developed to grow the Marek's disease herpesvirus in chicken kidney cells enabled researchers to attenuate virulent virus and develop the first effective vaccine. [7] This was the first report of an anti-viral vaccine being used to effectively prevent a naturally occurring cancer.
The site became known in 1986 as the Houghton Laboratory of the Institute for Animal Health. [8] The site closed in the 1992 due to budget realignments. It had been planned to close the site in August 1989.
In 1949 it found a strain of Eimeria tenella known as the Houghton strain, which allowed the researchers to study the Eimeria lifecycle. The site also researched coccidiosis.
It worked in the 1960s with the British Egg Marketing Board, collaborating with the University of Liverpool on research on avian infectious bronchitis. [9]
It developed a vaccine for Marek's disease in the 1960s. [10] In 1967 this disease was costing the industry £7m or about 2.5% of revenue.
Peter Biggs attended the 1967 World Poultry Congress in Kiev. He showed that cancer in poultry was heritable, due to the cancer complex of Leucosis, Marek's disease and acute Marek's disease. Leucosis alone caused 40% of mortality in egg-producing breeds. [11]
Herbert Williams-Smith FRS was head of microbiology until May 1984. [12] In 1969 a report on antibiotic growth promoters (AGPs) recommended a restriction of tetracycline, due to antibiotic resistance, which had been investigated by Herbert Williams-Smith in the early 1970s.
It was sited in Huntingdonshire off the A1123 near the junction with the B1090 Sawtry Way. The site has been redeveloped.
It had 33 laboratories. Its chickens laid around 2000 eggs a week.
Virulent Newcastle disease (VND), formerly exotic Newcastle disease, is a contagious viral avian disease affecting many domestic and wild bird species; it is transmissible to humans. Though it can infect humans, most cases are non-symptomatic; rarely it can cause a mild fever and influenza-like symptoms and/or conjunctivitis in humans. Its effects are most notable in domestic poultry due to their high susceptibility and the potential for severe impacts of an epizootic on the poultry industries. It is endemic to many countries. No treatment for VND is known, but the use of prophylactic vaccines and sanitary measures reduces the likelihood of outbreaks.
The Pirbright Institute is a research institute in Surrey, England, dedicated to the study of infectious diseases of farm animals. It forms part of the UK government's Biotechnology and Biological Sciences Research Council (BBSRC). The institute employs scientists, vets, PhD students and operations staff.
Coccidiosis is a parasitic disease of the intestinal tract of animals caused by coccidian protozoa. The disease spreads from one animal to another by contact with infected feces or ingestion of infected tissue. Diarrhea, which may become bloody in severe cases, is the primary symptom. Most animals infected with coccidia are asymptomatic, but young or immunocompromised animals may suffer severe symptoms and death.
Eimeria tenella is a species of Eimeria that causes hemorrhagic cecal coccidiosis in young poultry. It is found worldwide.
Eimeria is a genus of apicomplexan parasites that includes various species capable of causing the disease coccidiosis in animals such as cattle, poultry and smaller ruminants including sheep and goats. Eimeria species are considered to be monoxenous because the life cycle is completed within a single host, and stenoxenous because they tend to be host specific, although a number of exceptions have been identified. Species of this genus infect a wide variety of hosts. Thirty-one species are known to occur in bats (Chiroptera), two in turtles, and 130 named species infect fish. Two species infect seals. Five species infect llamas and alpacas: E. alpacae, E. ivitaensis, E. lamae, E. macusaniensis, and E. punonensis. A number of species infect rodents, including E. couesii, E. kinsellai, E. palustris, E. ojastii and E. oryzomysi. Others infect poultry, rabbits and cattle. For full species list, see below.
Poultry diseases occur in poultry, which are domesticated birds kept for their meat, eggs or feathers. Poultry species include the chicken, turkey, duck, goose and ostrich.
Marek's disease is a highly contagious viral neoplastic disease in chickens. It is named after József Marek, a Hungarian veterinarian who described it in 1907. Marek's disease is caused by an alphaherpesvirus known as "Marek's disease virus" (MDV) or Gallid alphaherpesvirus 2 (GaHV-2). The disease is characterized by the presence of T cell lymphoma as well as infiltration of nerves and organs by lymphocytes. Viruses related to MDV appear to be benign and can be used as vaccine strains to prevent Marek's disease. For example, the related herpesvirus found in turkeys (HVT), causes no apparent disease in the birds, and continues to be used as a vaccine strain for prevention of Marek's disease.
Gallid alphaherpesvirus 1 (GaHV-1) is a species of virus in the order Herpesvirales, family Herpesviridae, subfamily Alphaherpesvirinae, and genus Iltovirus. Originally recognised in chickens in the United States in 1926, this virus causes avian infectious laryngotracheitis, a potentially fatal, economically deleterious disease, widely recognised as one of the most contagious diseases in the poultry industry. The virus and its associated disease also occur in pheasants.
Lymphoid leucosis is a disease that affects chickens, caused by the retrovirus Avian leukosis virus.
Leucosis is a leukemia-like malignant viral disease that is found in animals, particularly poultry and cattle.
Specific-pathogen-free (SPF) is a term used for laboratory animals that are guaranteed free of particular pathogens. Use of SPF animals ensures that specified diseases do not interfere with an experiment. For example, absence of respiratory pathogens such as influenza is desirable when investigating a drug's effect on lung function.
Argas persicus, also known as fowl tick or poultry tick, is a small soft-bodied tick that is found primarily on domestic fowl such as chickens, ducks, and geese. It was first recorded by Lorenz Oken in 1818 in Mianeh, Persia, and named Rhynochoprion persicum.
Avian sarcoma leukosis virus (ASLV) is an endogenous retrovirus that infects and can lead to cancer in chickens; experimentally it can infect other species of birds and mammals. ASLV replicates in chicken embryo fibroblasts, the cells that contribute to the formation of connective tissues. Different forms of the disease exist, including lymphoblastic, erythroblastic, and osteopetrotic.
ATCvet code QI01Immunologicals for Aves is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System for veterinary medicinal products, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products for veterinary use. Subgroup QI01 is part of the anatomical group QI Immunologicals.
Pacheco's disease is a highly infectious and acute bird disease caused by a species of herpesvirus, Psittacid alphaherpesvirus 1 (PsHV-1). All psittacine species are susceptible to Pacheco's disease, mainly those in zoological collections and aviaries in any geographic regions. Specifically, Pacheco's disease has a high occurrence rate in Amazon parrots, followed by African grey parrots, parrots, macaws, cockatoos and conures. Due to a very high mortality rate within these susceptible species, concerns are brought to companion bird markets and breeders.
The avian immune system is the system of biological structures and cellular processes that protects birds from disease.
Egg drop syndrome '76 is a viral disease that affects birds, notably chickens, ducks, geese and swans. It is characterised by a sudden drop in production of eggs as well as its eggshell quality in apparent healthy laying birds.
Reticuloendotheliosis (RE) designates a group of pathologic syndromes caused by the reticuloendotheliosis virus (REV) group of avian retroviruses. The disease syndromes associated with REV include 1) a runting disease syndrome, 2) chronic neoplasia of lymphoid and other tissues, and 3) acute reticulum cell neoplasia.
Jessie Isabelle Price was a veterinary microbiologist. She isolated and reproduced the cause of the most common life-threatening disease in duck farming in the 1950s and developed vaccines for this and other avian diseases. A graduate of Cornell University, where she gained a PhD (1959), she worked first at the Cornell Duck Research Laboratory and later at the USGS National Wildlife Health Center. She served as chair of the Predoctoral Minority Fellowship Ad Hoc Review Committee of the American Society for Microbiology (ASM), and as president of Graduate Women in Science.
The National Veterinary Research Institute (NVRI) is a research institute in Nigeria that was established in 1924 and has the mandate to conduct research into how to ably identify, treat and control animal diseases as well as the development of vaccines for such and training and the provision of support services to livestock and poultry farmers. The institute is under the supervision of Federal Ministry of Agriculture and Rural Development. The chief executive is Maryam Muhammad, a veterinary doctor with research interests in the molecular epidemiology of Salmonella in poultry, public health and environment and development.