IFI6

IFI6
Identifiers
Aliases	IFI6 , 6-16, FAM14C, G1P3, IFI-6-16, IFI616, interferon alpha inducible protein 6
External IDs	OMIM: 147572 HomoloGene: 49720 GeneCards: IFI6
Gene location (Human)
Chr.	Chromosome 1 (human)
End	27,672,212 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; right lung; ; monocyte; ; Right adrenal gland; ; right coronary artery; ; periodontal fiber; ; right uterine tube; ; left lobe of thyroid gland; ; Left adrenal gland; ; ascending aorta;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	integral component of membrane ; plasma membrane ; membrane ; mitochondrion ;
Biological process	negative regulation of mitochondrial depolarization ; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ; type I interferon signaling pathway ; immune response ; release of cytochrome c from mitochondria ;
	Sources:Amigo / QuickGO
Orthologs
	2537
	n/a
	ENSG00000126709
	n/a
	P09912
	n/a
	NM_022873 ; NM_002038 ; NM_022872
	n/a
	NP_002029 ; NP_075010 ; NP_075011
	n/a
	Wikidata
View/Edit Human

Last updated October 12, 2022

Interferon alpha-inducible protein 6 is a protein that in humans is encoded by the IFI6 gene.^[3]

This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A mini-satellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described.^[3]

An antiviral function has been attributed to IFI6 against several members of theFlaviviridae family (DENV, YFV, ZIKV, WNV). IFI6 was able to interfere with the virus replication by preventing the formation of virus-induced membrane structures that represent a replication organelle.^[4]

Related Research Articles

Interferons are a group of signaling proteins made and released by host cells in response to the presence of several viruses. In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten their anti-viral defenses.

Endogenous retroviruses (ERVs) are endogenous viral elements in the genome that closely resemble and can be derived from retroviruses. They are abundant in the genomes of jawed vertebrates, and they comprise up to 5–8% of the human genome.

Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. It is a member of the STAT protein family.

Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor.

Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene. It is a member of the STAT protein family. This protein is critical to the biological response of type I interferons (IFNs). STAT2 sequence identity between mouse and human is only 68%.

Interferon-alpha/beta receptor beta chain is a protein that in humans is encoded by the IFNAR2 gene.

Interferon regulatory factor 1 is a protein that in humans is encoded by the IRF1 gene.

Interferon alpha-2 is a protein that in humans is encoded by the IFNA2 gene.

Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a protein that in humans is encoded by the IFI16 gene.

Interferon regulatory factor 9 is a protein that in humans is encoded by the IRF9 gene, previously known as ISGF3G.

Interferon-induced protein with tetratricopeptide repeats 1 is a protein that in humans is encoded by the IFIT1 gene.

Interferon alpha-inducible protein 27 is a protein that in humans is encoded by the IFI27 gene.

Interferon-induced protein with tetratricopeptide repeats 2 or IFIT2 is a protein found in humans which is encoded by the IFIT2 gene.

Myeloid cell Nuclear Differentiation Antigen is a protein that in humans is encoded as MNDA gene.

Interferon-induced transmembrane protein 1 is a protein that in humans is encoded by the IFITM1 gene. IFITM1 has also recently been designated CD225. This protein has several additional names: fragilis, IFI17 [interferon-induced protein 17], 9-27 [Interferon-inducible protein 9-27] and Leu13.

Interferon-induced 35 kDa protein is a protein that in humans is encoded by the IFI35 gene.

Interferon omega-1 is a protein that in humans is encoded by the IFNW1 gene.

Interferon-induced GTP-binding protein MX2/MXB is a protein that in humans is encoded by the MX2 gene.

Interferon-induced transmembrane protein 3 (IFITM3) is a protein that in humans is encoded by the IFITM3 gene. It plays a critical role in the immune system's defense against Swine Flu, where heightened levels of IFITM3 keep viral levels low, and the removal of IFITM3 allows the virus to multiply unchecked. This observation has been further advanced by a recent study from Paul Kellam's lab that shows that a single nucleotide polymorphism in the human IFITM3 gene purported to increase influenza susceptibility is overrepresented in people hospitalised with pandemic H1N1. The prevalence of this mutation is thought to be approximately 1/400 in European populations.

Interferon-induced transmembrane protein 2 is a protein that in humans is encoded by the IFITM2 gene. IFITM1 is a member of the IFITM family which is encoded by IFITM genes.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000126709 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: IFI6 interferon, alpha-inducible protein 6".
↑ Richardson RB, Ohlson MB, Eitson JL, Kumar A, McDougal MB, Boys IN, et al. (November 2018). "A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus replication". Nature Microbiology. 3 (11): 1214–1223. doi:10.1038/s41564-018-0244-1. PMC 6202210 . PMID 30224801.

Itzhaki JE, Barnett MA, MacCarthy AB, Buckle VJ, Brown WR, Porter AC (December 1992). "Targeted breakage of a human chromosome mediated by cloned human telomeric DNA". Nature Genetics. 2 (4): 283–287. doi:10.1038/ng1292-283. PMID 1303280. S2CID 38466985.
Clauss IM, Wathelet MG, Szpirer J, Content J, Islam MQ, Levan G, et al. (1990). "Chromosomal localization of two human genes inducible by interferons, double-stranded RNA, and viruses". Cytogenetics and Cell Genetics. 53 (2–3): 166–168. doi:10.1159/000132920. PMID 1695131.
Itzhaki JE, Porter AC (July 1991). "Targeted disruption of a human interferon-inducible gene detected by secretion of human growth hormone". Nucleic Acids Research. 19 (14): 3835–3842. doi:10.1093/nar/19.14.3835. PMC 328471 . PMID 1713665.
Kelly JM, Porter AC, Chernajovsky Y, Gilbert CS, Stark GR, Kerr IM (July 1986). "Characterization of a human gene inducible by alpha- and beta-interferons and its expression in mouse cells". The EMBO Journal. 5 (7): 1601–1606. doi:10.1002/j.1460-2075.1986.tb04402.x. PMC 1166985 . PMID 3017706.
Porter AC, Chernajovsky Y, Dale TC, Gilbert CS, Stark GR, Kerr IM (January 1988). "Interferon response element of the human gene 6-16". The EMBO Journal. 7 (1): 85–92. doi:10.1002/j.1460-2075.1988.tb02786.x. PMC 454218 . PMID 3359997.
Friedman RL, Manly SP, McMahon M, Kerr IM, Stark GR (October 1984). "Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells". Cell. 38 (3): 745–755. doi:10.1016/0092-8674(84)90270-8. PMID 6548414. S2CID 37810920.
Turri MG, Cuin KA, Porter AC (June 1995). "Characterisation of a novel minisatellite that provides multiple splice donor sites in an interferon-induced transcript". Nucleic Acids Research. 23 (11): 1854–1861. doi:10.1093/nar/23.11.1854. PMC 306954 . PMID 7596809.
Hofmann WA, Stojiljkovic L, Fuchsova B, Vargas GM, Mavrommatis E, Philimonenko V, et al. (November 2004). "Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II". Nature Cell Biology. 6 (11): 1094–1101. doi:10.1038/ncb1182. PMID 15502823. S2CID 23909479.
Tahara E, Tahara H, Kanno M, Naka K, Takeda Y, Matsuzaki T, et al. (August 2005). "G1P3, an interferon inducible gene 6-16, is expressed in gastric cancers and inhibits mitochondrial-mediated apoptosis in gastric cancer cell line TMK-1 cell". Cancer Immunology, Immunotherapy. 54 (8): 729–740. doi:10.1007/s00262-004-0645-2. PMID 15685448. S2CID 13399785.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000126709 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] 1 2 "Entrez Gene: IFI6 interferon, alpha-inducible protein 6".

[pmid30224801-4] Richardson RB, Ohlson MB, Eitson JL, Kumar A, McDougal MB, Boys IN, et al. (November 2018). "A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus replication". Nature Microbiology. 3 (11): 1214–1223. doi:10.1038/s41564-018-0244-1. PMC 6202210 . PMID 30224801.

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IFI6

Related Research Articles

References

Further reading