IFT74

IFT74
Identifiers
Aliases	IFT74 , CCDC2, CMG-1, CMG1, intraflagellar transport 74, BBS20, BBS22, SPGF58, JBTS40
External IDs	OMIM: 608040; MGI: 1914944; HomoloGene: 11831; GeneCards: IFT74; OMA:IFT74 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9p21.2 Start 26,947,039 bp [1] End 27,066,134 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 C5 Start 94,614,491 bp [2] End 94,693,229 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell caput epididymis right uterine tube Achilles tendon corpus epididymis left testis right testis testicle gonad mucosa of paranasal sinus Top expressed in seminiferous tubule olfactory epithelium spermatid spermatocyte maxillary prominence mandibular prominence saccule Gonadal ridge otic vesicle Epithelium of choroid plexus More reference expression data BioGPS n/a
Gene ontology Molecular function chromatin binding beta-tubulin binding protein binding Cellular component intraciliary transport particle B centrosome cell projection ciliary tip motile cilium cytoplasmic vesicle nucleus cilium Biological process Notch signaling pathway intraciliary transport heart development keratinocyte development determination of left/right symmetry cell projection organization epidermis development negative regulation of epithelial cell proliferation positive regulation of cell adhesion mediated by integrin positive regulation of transcription by RNA polymerase II intraciliary transport involved in cilium assembly cilium assembly non-motile cilium assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80173 67694 Ensembl ENSG00000096872 ENSMUSG00000028576 UniProt Q96LB3 Q8BKE9 RefSeq (mRNA) NM_001099222 NM_001099223 NM_001099224 NM_025103 NM_001349928 NM_001290568 NM_026319 RefSeq (protein) NP_001092692 NP_001092693 NP_001092694 NP_079379 NP_001336857 NP_001277497 NP_080595 Location (UCSC) Chr 9: 26.95 – 27.07 Mb Chr 4: 94.61 – 94.69 Mb PubMed search [3] [4]
Wikidata
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Intraflagellar transport protein 74 homolog (IFT74), also known as coiled-coil domain-containing protein 2 (CCDC2) and capillary morphogenesis gene 1 protein (CMG1), is a protein that in humans is encoded by the IFT74 gene. ^{[5] [6]}

BCMG1 is upregulated by umbilical vein endothelial cells during capillary morphogenesis. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000096872 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028576 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: intraflagellar transport 74 homolog (Chlamydomonas)".
6. Bell SE, Mavila A, Salazar R, Bayless KJ, Kanagala S, Maxwell SA, Davis GE (August 2001). "Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling". J. Cell Sci. 114 (Pt 15): 2755–73. doi:10.1242/jcs.114.15.2755. PMID   11683410.

Further reading

• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Xiao S, Sato C, Kawarai T, et al. (2008). "Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis". Neurobiol. Aging. 29 (8): 1279–82. doi:10.1016/j.neurobiolaging.2007.02.022. PMID   17383054. S2CID   10392826.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.