ILKAP

ILKAP
Identifiers
Aliases	ILKAP , ILKAP2, ILKAP3, PP2C-DELTA, PPM1O, ILK associated serine/threonine phosphatase, PP2CD
External IDs	MGI: 1914694 HomoloGene: 31525 GeneCards: ILKAP
Gene location (Human)
Chr.	Chromosome 2 (human)
End	238,203,708 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	91,398,815 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; gastric mucosa; ; anterior pituitary; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; tibial nerve; ; sural nerve; ; canal of the cervix; ; skin of abdomen; ; left uterine tube;
	Top expressed in
	neural tube; ; thymus; ; lip; ; abdominal wall; ; superior frontal gyrus; ; ganglionic eminence; ; cerebellar cortex; ; adrenal gland; ; maxillary prominence; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein serine/threonine phosphatase activity ; protein binding ; catalytic activity ; phosphoprotein phosphatase activity ; hydrolase activity ; metal ion binding ; cation binding ;
Cellular component	cytoplasm ; nucleus ; nucleoplasm ; cytosol ;
Biological process	protein dephosphorylation ;
	Sources:Amigo / QuickGO
Orthologs
	80895
	67444
	ENSG00000132323
	ENSMUSG00000026309
	Q9H0C8
	Q8R0F6
	NM_030768 ; NM_176799
	NM_023343 ; NM_001355152
	NP_110395
	NP_075832 ; NP_001342081
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Integrin-linked kinase-associated serine/threonine phosphatase 2C is an enzyme that in humans is encoded by the ILKAP gene.^[5]

The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway.^[5]

Interactions

ILKAP has been shown to interact with Integrin-linked kinase.^[6]

Related Research Articles

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Integrin-linked kinase is an enzyme that in humans is encoded by the ILK gene involved with integrin-mediated signal transduction. Mutations in ILK are associated with cardiomyopathies. It is a 59kDa protein originally identified in a yeast-two hybrid screen with integrin β1 as the bait protein. Since its discovery, ILK has been associated with multiple cellular functions including cell migration, proliferation, and adhesion.

Protein kinase C delta type is an enzyme that in humans is encoded by the PRKCD gene.

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit is an enzyme that in humans is encoded by the PPP1CA gene.

Serine/threonine-protein phosphatase 5 is an enzyme that in humans is encoded by the PPP5C gene.

Serine/threonine-protein kinase D1 is an enzyme that in humans is encoded by the PRKD1 gene.

Calcium and integrin-binding protein 1 is a protein that in humans is encoded by the CIB1 gene.

Polo-like kinase 3 (Drosophila), also known as PLK3, is an enzyme which in humans is encoded by the PLK3 gene.

Receptor-type tyrosine-protein phosphatase epsilon is an enzyme that in humans is encoded by the PTPRE gene.

Protein phosphatase 1D is an enzyme that in humans is encoded by the PPM1D gene.

Protein phosphatase 1A is an enzyme that in humans is encoded by the PPM1A gene.

MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform is an enzyme that in humans is encoded by the PPP2R5B gene.

MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MKNK2 gene.

Serine/threonine-protein kinase 38 is an enzyme that in humans is encoded by the STK38 gene.

Serine/threonine-protein kinase PLK2 is an enzyme that in humans is encoded by the PLK2 gene.

STE20-related kinase adapter protein beta is an enzyme that in humans is encoded by the STRADB gene.

Death-associated protein kinase 2 is an enzyme that in humans is encoded by the DAPK2 gene.

Protein tyrosine phosphatase receptor type C-associated protein is an enzyme that in humans is encoded by the PTPRCAP gene.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000132323 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026309 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: ILKAP integrin-linked kinase-associated serine/threonine phosphatase 2C".
↑ Leung-Hagesteijn C, Mahendra A, Naruszewicz I, Hannigan GE (May 2001). "Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1". The EMBO Journal. 20 (9): 2160–70. doi:10.1093/emboj/20.9.2160. PMC 125446 . PMID 11331582.

Tong Y, Quirion R, Shen SH (December 1998). "Cloning and characterization of a novel mammalian PP2C isozyme". The Journal of Biological Chemistry. 273 (52): 35282–90. doi: 10.1074/jbc.273.52.35282 . PMID 9857069.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Leung-Hagesteijn C, Mahendra A, Naruszewicz I, Hannigan GE (May 2001). "Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1". The EMBO Journal. 20 (9): 2160–70. doi:10.1093/emboj/20.9.2160. PMC 125446 . PMID 11331582.
Kumar AS, Naruszewicz I, Wang P, Leung-Hagesteijn C, Hannigan GE (April 2004). "ILKAP regulates ILK signaling and inhibits anchorage-independent growth". Oncogene. 23 (19): 3454–61. doi: 10.1038/sj.onc.1207473 . PMID 14990992.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000132323 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026309 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: ILKAP integrin-linked kinase-associated serine/threonine phosphatase 2C".

[pmid11331582-6] Leung-Hagesteijn C, Mahendra A, Naruszewicz I, Hannigan GE (May 2001). "Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1". The EMBO Journal. 20 (9): 2160–70. doi:10.1093/emboj/20.9.2160. PMC 125446 . PMID 11331582.

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ILKAP

Contents

Interactions

Related Research Articles

References

Further reading