INPP4A

INPP4A
Identifiers
Aliases	INPP4A , INPP4, TVAS1, inositol polyphosphate-4-phosphatase type I A
External IDs	OMIM: 600916; MGI: 1931123; HomoloGene: 2871; GeneCards: INPP4A; OMA:INPP4A - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q11.2 Start 98,444,854 bp [1] End 98,594,392 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 B|1 15.46 cM Start 37,338,946 bp [2] End 37,449,817 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 endothelial cell tibia entorhinal cortex postcentral gyrus superior frontal gyrus buccal mucosa cell middle temporal gyrus lateral nuclear group of thalamus visceral pleura Top expressed in perirhinal cortex entorhinal cortex CA3 field trigeminal ganglion primary visual cortex superior frontal gyrus granulocyte dentate gyrus of hippocampal formation granule cell cerebellar cortex Region I of hippocampus proper More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity protein binding hydrolase activity inositol-3,4-bisphosphate 4-phosphatase activity phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity inositol-1,3,4-trisphosphate 4-phosphatase activity Cellular component cytosol cytoplasm Biological process phosphatidylinositol biosynthetic process phosphatidylinositol-3-phosphate biosynthetic process inositol phosphate metabolic process signal transduction dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3631 269180 Ensembl ENSG00000040933 ENSMUSG00000026113 UniProt Q96PE3 Q9EPW0 RefSeq (mRNA) NM_001134224 NM_001134225 NM_001566 NM_004027 NM_001351424 NM_001351425 NM_001351426 NM_001351427 NM_001351428 NM_001351429 NM_001290797 NM_001290798 NM_001290799 NM_030266 NM_172971 NM_001374629 NM_001374630 RefSeq (protein) NP_001127696 NP_001127697 NP_001557 NP_004018 NP_001338353 NP_001338354 NP_001338355 NP_001338356 NP_001338357 NP_001338358 NP_001277726 NP_001277727 NP_001277728 NP_084542 NP_766559 NP_001361558 NP_001361559 Location (UCSC) Chr 2: 98.44 – 98.59 Mb Chr 1: 37.34 – 37.45 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Type I inositol-3,4-bisphosphate 4-phosphatase is an enzyme that in humans is encoded by the INPP4A gene. ^{[5] [6] [7]}

INPP4A encodes the inositol polyphosphate 4-phosphatase type I, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000040933 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026113 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Norris FA, Auethavekiat V, Majerus PW (Aug 1995). "The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase". J Biol Chem. 270 (27): 16128–33. doi: 10.1074/jbc.270.27.16128 . PMID   7608176.
6. Norris FA, Atkins RC, Majerus PW (Oct 1997). "The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family". J Biol Chem. 272 (38): 23859–64. doi: 10.1074/jbc.272.38.23859 . PMID   9295334.
7. "Entrez Gene: INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa".

Further reading

• Zhang X, Majerus PW (1998). "Phosphatidylinositol signalling reactions". Semin. Cell Dev. Biol. 9 (2): 153–60. doi:10.1006/scdb.1997.0220. PMID   9599410.
• Norris FA, Atkins RC, Majerus PW (1997). "Inositol polyphosphate 4-phosphatase is inactivated by calpain-mediated proteolysis in stimulated human platelets". J. Biol. Chem. 272 (17): 10987–9. doi: 10.1074/jbc.272.17.10987 . PMID   9110986.
• Munday AD, Norris FA, Caldwell KK, et al. (1999). "The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol". Proc. Natl. Acad. Sci. U.S.A. 96 (7): 3640–5. Bibcode:1999PNAS...96.3640M. doi: 10.1073/pnas.96.7.3640 . PMC   22347 . PMID   10097090.
• Joseph RE, Walker J, Norris FA (2000). "Assignment of the inositol polyphosphate 4-phosphatase type I gene (INPP4A) to human chromosome band 2q11.2 by in situ hybridization". Cytogenet. Cell Genet. 87 (3–4): 276–7. doi:10.1159/000015448. PMID   10702694. S2CID   40002118.
• Shearn CT, Walker J, Norris FA (2001). "Identification of a novel spliceoform of inositol polyphosphate 4-phosphatase type Ialpha expressed in human platelets: structure of human inositol polyphosphate 4-phosphatase type I gene". Biochem. Biophys. Res. Commun. 286 (1): 119–25. doi:10.1006/bbrc.2001.5331. PMID   11485317.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ivetac I, Munday AD, Kisseleva MV, et al. (2005). "The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane". Mol. Biol. Cell. 16 (5): 2218–33. doi:10.1091/mbc.E04-09-0799. PMC   1087230 . PMID   15716355.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.