Immunologic activation

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In immunology, activation is the transition of leucocytes and other cell types involved in the immune system. On the other hand, deactivation is the transition in the reverse direction. [1] This balance is tightly regulated, since a too small degree of activation causes susceptibility to infections, while, on the other hand, a too large degree of activation causes autoimmune diseases.

Contents

Factors

Activation and deactivation results from a variety of factors, including cytokines, soluble receptors, arachidonic acid metabolites, steroids, receptor antagonists, adhesion molecules, bacterial products and viral products. [1]

Overview of activating and deactivating factors.
ActivationDeactivation
Cytokines
Soluble receptors
Arachidonic acid metabolites
Steroids
Receptor antagonists
Adhesion molecules
Bacterial products
Viral products

See also

References

  1. 1 2 Kane, Barry A.; Bryant, Katherine J.; McNeil, H. Patrick; Tedla, Nicodemus T. (2014). "Termination of immune activation: an essential component of healthy host immune responses". Journal of Innate Immunity. 6 (6): 727–738. doi:10.1159/000363449. ISSN   1662-8128. PMC   6741560 . PMID   25033984.
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