International Society for Extracellular Vesicles

Last updated
International Society for Extracellular Vesicles
Founded2011
Type Professional organization
Focus Extracellular vesicles
Area served
Worldwide
MethodConferences, publications, education
Members
>2000
Key people
 Kenneth W. Witwer (president]
Edit Buzás (immediate past-president)
Clotilde Théry (past-president and founding secretary general)
Andrew Hill (past-president)
Jan Lötvall (founding president)
Website isev.org

The International Society for Extracellular Vesicles (ISEV) is an international scientific organization that focuses on advancing global extracellular vesicle (EV) research. [1] These membrane-bound particles are released from all known cells and include exosomes, ectosomes, exophers, oncosomes, and more. Established in 2011, the society is a nonprofit organization. It is governed by an executive committee. The current president is Kenneth Witwer. Previous presidents were Edit Buzás (2022-2024), Clotilde Théry (2018-2022), Andrew Hill (2016-2018) and founding president Jan Lötvall (2011-2016). The society's journals are the Journal of Extracellular Vesicles and the Journal of Extracellular Biology . [2] ISEV also publishes the international consensus guidelines for EV studies, the "Minimal information for studies of EVs" (MISEV). [3] [4]

Contents

ISEV has several committees (Meetings and Programs, Science and Journals, Rigor and Standardization, Education, Translation, Regulation, and Advocacy Committee, and Communications and Membership) focused on advancing research and promoting awareness in the EVs. Each committee has specific roles and goals.

Meetings

As part of its mission to promote scientific research and education, the society hosts annual meetings and educational event as well as numerous workshops on defined EV-related topics. The society also co-sponsors or endorses related events.

Annual meetingLocation
ISEV2024Melbourne, Australia
ISEV2023Seattle, USA
ISEV2022Lyon, France
ISEV2021Virtual Meeting
ISEV2020Virtual Meeting
ISEV2019Kyoto, Japan
ISEV2018Barcelona, Spain
ISEV2017Toronto, Canada
ISEV2016Rotterdam, Netherlands
ISEV2015Washington DC, USA
ISEV2014Rotterdam, Netherlands
ISEV2013Boston, USA
ISEV2012Gothenburg, Sweden

Workshops and scientific seminars

ISEV workshops began with a meeting on extracellular RNA (New York City, 2012), [5] [6] [7] and continue to include one to two meetings per year. During widespread restrictions on in-person meetings during the COVID-19 pandemic, ISEV introduced the "Extracellular Vesicle Club," a weekly virtual event featuring presentations and moderated discussion of scientific publications. [8]

TopicLocationYear
Blood EVsSouth KoreaSeptember 2024
Large Extracellular VesiclesUnited StatesMarch 2024
EV-based BiomarkersDenmarkOctober 2023
Workshop by EV-TRACK Task ForceVirtualMarch 2023
The second Urine EV Task Force Virtual Symposium on Urinary Extracellular VesiclesVirtualFebruary 2023
QuantitatEVs: Multiscale analyses, from bulk to single vesicleRome and MilanJanuary-February 2023
Blood EVs: an ISEV WorkshopFinlandSeptember 2022
massivEVs WorkshopItaly/VirtuallyOctober 2021
Infectious Diseases MeetingVirtualJanuary 2021
EV Imaging in VivoFranceSeptember 2020
EVs in ImmunologyBuenos AiresMarch 2020
Open, Reproducible and Standardized EV ResearchBelgiumDecember 2019
EV-based Clinical TheranosticsChinaNovember 2018
Membranes and EVs WorkshopUnited StatesMarch 2018
Extracellular Vesicles as Biomarkers of DiseaseUnited KingdomDecember 2017
Diet, Environment and Extracellular VesiclesAustraliaJanuary 2017
Cross-Organism Communication by Extracellular Vesicles: Hosts, Microbes, ParasitesBrazilNovember 2016
Research Seminar: EV-associated RNA: Is there a purpose?NetherlandsSeptember 2015
ISEV Workshop on Isolation and Characterization of Extracellular VesiclesHungaryOctober 2013
ISEV RNA WorkshopUnited StatesOctober 2012

Endorsed or co-sponsored events

The society has directly or indirectly supported EV-related events around the world. These include meetings of the UK, French, and Spanish and Portuguese EV Societies (GEIVEX), a course of the European Molecular Biology Laboratory, Keystone Symposia (2016 and 2018), [9] Gordon Research Conferences (2016, 2018, and 2022), [10] a Cold Spring Harbor Asia Meeting (2016), [11] and others.

Journal of Extracellular Vesicles, Journal of Extracellular Biology, and standardization initiatives

To disseminate research in the field, the society established the peer-reviewed open access Journal of Extracellular Vesicles in 2012. [12] The journal was initially published by Co-Action Publishing, by Taylor & Francis from 2016-2020, and by Wiley since 2020. In addition to research and review articles, the journal periodically publishes position papers of the society that are meant to advance standardization efforts. [6] [7] In 2014, the Executive Board of Directors published a set of minimal information guidelines for publication of EV studies. [13] [14] These requirements, known as "MISEV" or "MISEV2014," mirrored similar initiatives in the fields of microarray (MIAME) and proteomics (MIAPE) analysis, among others. In 2017, the society's board announced its intent to update these requirements with community involvement. [15] The "MISEV2018" requirements were published in 2018 by Clotilde Théry and Kenneth Witwer with input from 380 co-authors. [16] The current consensus guidelines, known as "MISEV2023", were prepared with input from more than 1050 co-authors, using extensive crowdsourcing of expert opinion to build consensus. [4] The corresponding authors are Joshua Welsh, Deborah Goberdhan, Lorraine O'Driscoll, Clotilde Théry and Kenneth Witwer. [3]

In 2021, ISEV founded a second journal, the Journal of Extracellular Biology, focusing on EVs but also other extracellular particles (EPs) and phenomena. [2] [17] The editor-in-chief is Andrew Hill.

Education

Among the educational initiatives of the society are massive open online courses (MOOCs), launched in 2016. MOOC 1&II are available through Coursera [18] [19] and co-sponsored by the University of Gothenburg, Pohang University of Science and Technology, and the University of California, Irvine. [20] MOOC III is available on YouTube

Student Network on Extracellular Vesicles

In 2020, the Student Network on Extracellular Vesicles (SNEV) was founded as a virtual network for early-career researchers in EV research. SNEV’s activities include organizing online scientific talks, a monthly newsletter, industry talks and informal meet-and-greets (coffee catch ups). SNEV has organized two virtual conferences, one in 2021 and the second in 2023. Since 2024, SNEV has become the official early career within ISEV.

[TD1]Link to Student Network on Extracellular Vesicles (wordpress.com)

Related Research Articles

<span class="mw-page-title-main">Endocytosis</span> Cellular process

Endocytosis is a cellular process in which substances are brought into the cell. The material to be internalized is surrounded by an area of cell membrane, which then buds off inside the cell to form a vesicle containing the ingested materials. Endocytosis includes pinocytosis and phagocytosis. It is a form of active transport.

<span class="mw-page-title-main">Vesicle (biology and chemistry)</span> Any small, fluid-filled, spherical organelle enclosed by a membrane

In cell biology, a vesicle is a structure within or outside a cell, consisting of liquid or cytoplasm enclosed by a lipid bilayer. Vesicles form naturally during the processes of secretion (exocytosis), uptake (endocytosis), and the transport of materials within the plasma membrane. Alternatively, they may be prepared artificially, in which case they are called liposomes. If there is only one phospholipid bilayer, the vesicles are called unilamellar liposomes; otherwise they are called multilamellar liposomes. The membrane enclosing the vesicle is also a lamellar phase, similar to that of the plasma membrane, and intracellular vesicles can fuse with the plasma membrane to release their contents outside the cell. Vesicles can also fuse with other organelles within the cell. A vesicle released from the cell is known as an extracellular vesicle.

Microparticles are particles between 0.1 and 100 μm in size. Commercially available microparticles are available in a wide variety of materials, including ceramics, glass, polymers, and metals. Microparticles encountered in daily life include pollen, sand, dust, flour, and powdered sugar. The study of microparticles has been called micromeritics, although this term is not very common.

<span class="mw-page-title-main">Exosome (vesicle)</span> Membrane-bound extracellular vesicles

Exosomes, ranging in size from 30 to 150 nanometers, are membrane-bound extracellular vesicles (EVs) that are produced in the endosomal compartment of most eukaryotic cells. In multicellular organisms, exosomes and other EVs are found in biological fluids including saliva, blood, urine and cerebrospinal fluid. EVs have specialized functions in physiological processes, from coagulation and waste management to intercellular communication.

<span class="mw-page-title-main">Adrenal tumor</span> Tumors of the adrenal gland, usually resulting in hormone overproduction

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<span class="mw-page-title-main">Microvesicle</span> Type of extracellular vesicle

Microvesicles are a type of extracellular vesicle (EV) that are released from the cell membrane. In multicellular organisms, microvesicles and other EVs are found both in tissues and in many types of body fluids. Delimited by a phospholipid bilayer, microvesicles can be as small as the smallest EVs or as large as 1000 nm. They are considered to be larger, on average, than intracellularly-generated EVs known as exosomes. Microvesicles play a role in intercellular communication and can transport molecules such as mRNA, miRNA, and proteins between cells.

<span class="mw-page-title-main">CD63</span> Mammalian protein found in humans

CD63 antigen is a protein that, in humans, is encoded by the CD63 gene. CD63 is mainly associated with membranes of intracellular vesicles, although cell surface expression may be induced.

Jan Lötvall is a Swedish clinical allergist and scientist working on translational research primarily in the field of asthma. He is the former director of the Krefting Research Centre at the University of Gothenburg and is the Chief Scientific Officer of ExoCoBio.

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Extracellular RNA (exRNA) describes RNA species present outside of the cells in which they were transcribed. Carried within extracellular vesicles, lipoproteins, and protein complexes, exRNAs are protected from ubiquitous RNA-degrading enzymes. exRNAs may be found in the environment or, in multicellular organisms, within the tissues or biological fluids such as venous blood, saliva, breast milk, urine, semen, menstrual blood, and vaginal fluid. Although their biological function is not fully understood, exRNAs have been proposed to play a role in a variety of biological processes including syntrophy, intercellular communication, and cell regulation. The United States National Institutes of Health (NIH) published in 2012 a set of Requests for Applications (RFAs) for investigating extracellular RNA biology. Funded by the NIH Common Fund, the resulting program was collectively known as the Extracellular RNA Communication Consortium (ERCC). The ERCC was renewed for a second phase in 2019.

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Tunable resistive pulse sensing (TRPS) is a single-particle technique used to measure the size, concentration and zeta potential of particles as they pass through a size-tunable nanopore.

Extracellular vesicles (EVs) are lipid bilayer-delimited particles that are naturally released from almost all types of cells but, unlike a cell, cannot replicate. EVs range in diameter from near the size of the smallest physically possible unilamellar liposome to as large as 10 microns or more, although the vast majority of EVs are smaller than 200 nm. EVs can be divided according to size and synthesis route into exosomes, microvesicles and apoptotic bodies. The composition of EVs varies depending on their parent cells, encompassing proteins, lipids, nucleic acids, metabolites, and even organelles. Most cells that have been studied to date are thought to release EVs, including some archaeal, bacterial, fungal, and plant cells that are surrounded by cell walls. A wide variety of EV subtypes have been proposed, defined variously by size, biogenesis pathway, cargo, cellular source, and function, leading to a historically heterogenous nomenclature including terms like exosomes and ectosomes.

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<i>Journal of Extracellular Vesicles</i> Academic journal

The Journal of Extracellular Vesicles, JEV, is a peer-reviewed open-access scientific journal of the International Society for Extracellular Vesicles (ISEV). As one of two official journals of ISEV, the other being the Journal of Extracellular Biology, JEV covers research on lipid bilayer-delimited particles known as extracellular vesicles (EVs). EVs are released from cells and include endosome-origin exosomes and plasma membrane-derived ectosomes/microvesicles. The journal was established in 2012 and is currently published by Wiley. The founding editors-in-chief were Clotilde Théry, Yong Song Gho, and Peter Quesenberry. The current editor-in-chief is Jan Lötvall.

<span class="mw-page-title-main">Clotilde Théry</span> French cell biologist

Clotilde Théry is a professor and INSERM director of research (DR2) at Institut Curie in Paris, France. She is president of the International Society for Extracellular Vesicles (ISEV), where she previously served as founding secretary general and as editor-in-chief of the Journal of Extracellular Vesicles. She is the team leader of the group "Extracellular Vesicles, Immune Responses and Cancer" within the INSERM Unit 932 focusing on "Immunity and Cancer." Théry researches extracellular vesicles that are released by immune and tumor cells, including exosomes that originate in the multivesicular body.

<span class="mw-page-title-main">Kenneth Witwer</span> American biologist

Kenneth W. Witwer is an associate professor of molecular and comparative pathobiology and neurology at the Johns Hopkins University School of Medicine in Baltimore, Maryland, United States. He is President of the International Society for Extracellular Vesicles (ISEV) and previously served as Secretary General and Executive Chair of Science and Meetings of the society. His laboratory studies extracellular vesicles (EVs), noncoding and extracellular RNA (exRNA), and enveloped viruses, including HIV and SARS-CoV-2. Witwer is the managing editor of the journal Cytotherapy and a member of the Richman Family Precision Medicine Center of Excellence in Alzheimer's Disease. He has advised the US Environmental Protection Agency and the US National Institutes of Health and is an associate editor of the Journal of Extracellular Vesicles.

<span class="mw-page-title-main">Jessica A. Scoffield</span> American microbiologist

Jessica A. Scoffield is an American microbiologist and an assistant professor in the Department of Microbiology at the University of Alabama at Birmingham School of Medicine. Scoffield studies the mechanisms by which oral commensal bacteria interfere with pathogenic bacterial growth in order to inform the development of active therapeutic tools to prevent drug resistant pathogen infection. In 2019, Scoffield became the inaugural recipient of the American Association for Dental Research Procter and Gamble Underrepresented Faculty Research Fellowship.

<span class="mw-page-title-main">Exopher</span>

Exophers are a type of membrane-bound extracellular vesicle (EV) that are released by budding out of cells into the extracellular space. Exophers can be released by neurons and muscle in the nematode Caenorhabditis elegans and also from murine cardiomyocytes. Exophers were first discovered in 2017 by an undergraduate student in the lab of Monica Driscoll at Rutgers University.

<span class="mw-page-title-main">Intercellular communication</span>

Intercellular communication (ICC) refers to the various ways and structures that biological cells use to communicate with each other directly or through their environment. Often the environment has been thought of as the extracellular spaces within an animal. More broadly cells may also communicate with other animals, either of their own group or species, or other species in the wider ecosystem. Different types of cells use different proteins and mechanisms to communicate with one another using extracellular signalling molecules or electric fluctuations which could be likened to an intercellular ethernet. Components of each type of intercellular communication may be involved in more than one type of communication making attempts at clearly separating the types of communication listed somewhat futile. Broadly speaking, intercellular communication may be categorized as being within a single animal, or between an animal and other animals in the ecosystem in which it lives. In this article intercellular communication has been further collated into various areas of research rather than by functional or structural characteristics.

<span class="mw-page-title-main">Stefano Pluchino</span> Italian researcher

Stefano Pluchino is Professor of Regenerative Neuroimmunology, within the Department of Clinical Neurosciences, at the University of Cambridge. His research studies whether the accumulation of neurological disability observed in patients with chronic inflammatory neurological conditions can be slowed down using next generation molecular therapies. The overarching aim is to understand the basic mechanisms that allow exogenously delivered stem cells, gene therapy vectors and/or exosomes to create an environment that preserves damaged axons or prevents neurons from dying. Such mechanisms are being harnessed and used to modulate disease states to repair and/or regenerate critical components of the nervous system.

References

  1. ↑ "Better living through mitochondrial derived vesicles". MedicalXpress.
  2. 1 2 Hill AF, Sahoo S (March 2022). "Launching the Journal of Extracellular Biology (J Ex Bio) – A new journal from the International Society for Extracellular Vesicles (ISEV)". Journal of Extracellular Biology. 1 (1). e19. doi: 10.1002/jex2.19 . PMC   11080626 . S2CID   247483494.
  3. 1 2 Welsh JA, et al. (2024). "Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches". J. Extracell. Vesicles. 13 (2): e12404. doi:10.1002/jev2.12404. PMC   10850029 . PMID   38326288.
  4. 1 2 Welsh JA, et al. (2024). "MISEV2023: An updated guide to EV research and applications". J. Extracell. Vesicles. 13 (2): 12416. doi:10.1002/jev2.12416. PMC   10891433 . PMID   38400602.
  5. ↑ "RNA Workshop". Archived from the original on 2014-05-30. Retrieved 2014-04-29.
  6. 1 2 Witwer, K. W.; Buzás, E.I.; Bemis, L.T.; Bora, A.; Lässer, C.; Lötvall, J.; Nolte-'t Hoen, E.N.; Piper, M.G.; Sivaraman, S.; Skog, J.; Théry, C.; Wauben, M.H.; Hochberg, F. (2013). "Standardization of sample collection, isolation and analysis methods in extracellular vesicle research". Journal of Extracellular Vesicles. 2: 20360. doi:10.3402/jev.v2i0.20360. PMC   3760646 . PMID   24009894.
  7. 1 2 Hill, A.F.; Pegtel, D.M.; Lambertz, U.; Leonardi, T.; O'Driscoll, L.; Pluchino, S.; Ter-Ovanesyan, D.; Nolte-'t Hoen, E.N. (2013). "ISEV position paper: Extracellular vesicle RNA analysis and bioinformatics". Journal of Extracellular Vesicles. 2: 22859. doi:10.3402/jev.v2i0.22859. PMC   3873759 . PMID   24376909.
  8. ↑ "International Society for Extracellular Vesicles Launches EV Club". WFMZ-TV News Allentown. 20 April 2021. Retrieved 22 April 2021.
  9. ↑ "Scientific Conferences on Biomedical and Life Science Topics". Keystone Symposia .
  10. ↑ "2016 Extracellular Vesicles Conference GRC". Gordon Research Conferences.
  11. ↑ "CSH Asia 2016 Conference on Biology & Function of Extracellular Vesicles: Exosomes, Microvesicles & Beyond". Cold Spring Harbor Asia.
  12. ↑ "Journal information". Journal of Extracellular Vesicles.
  13. ↑ Lötvall, J.; Hill, A.F.; Hochberg, F.; Buzás, E.I.; Di Vizio, D.; Gardiner, C.; Gho, Y.S.; Kurochkin, I.V.; Mathivanan, S.; Quesenberry, P.; Sahoo, S.; Tahara, H.; Wauben, M.H.; Witwer, K.W.; Théry, C. (2014). "Minimal experimental requirements for definition of extracellular vesicles and their functions: A position statement from the International Society for Extracellular Vesicles". Journal of Extracellular Vesicles. 3: 26913. doi:10.3402/jev.v3.26913. PMC   4275645 . PMID   25536934.
  14. ↑ "Enhanced Analysis of Extracellular Vesicles with Imaging Flow Cytometry". Archived from the original on 2015-12-08. Retrieved 2015-11-28.
  15. ↑ Witwer, Kenneth W.; Soekmadji, Carolina; Hill, Andrew F.; Wauben, Marca H.; Buzás, Edit I.; Di Vizio, Dolores; Falcon-Perez, Juan M.; Gardiner, Chris; Hochberg, Fred; Kurochkin, Igor V.; Lötvall, Jan; Mathivanan, Suresh; Nieuwland, Rienk; Sahoo, Susmita; Tahara, Hidetoshi; Torrecilhas, Ana Claudia; Weaver, Alissa M.; Yin, Hang; Zheng, Lei; Gho, Yong Song; Quesenberry, Peter; Théry, Clotilde (2017). "Updating the MISEV minimal requirements for extracellular vesicle studies: building bridges to reproducibility". Journal of Extracellular Vesicles. 6 (1): 1396823. doi:10.1080/20013078.2017.1396823. ISSN   2001-3078. PMC   5698937 . PMID   29184626.
  16. ↑ Théry, C. (2018). "Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines". Journal of Extracellular Vesicles. 7 (1): 1535750. doi:10.1080/20013078.2018.1535750. PMC   6322352 . PMID   30637094.
  17. ↑ "Journal of Extracellular Biology (Wiley)".
  18. ↑ "Basics of Extracellular Vesicles". Coursera.
  19. ↑ "Extracellular Vesicles in Health and Disease".
  20. ↑ "Well-Attended Two-Track Education Day Precedes Opening of International Society for Extracellular Vesicles (ISEV 2016) Annual Meeting in Rotterdam May 4-7". BioQuick News.com (Press release). 3 May 2016.
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