In 1992, Germano joined the neurosurgery faculty at Mount Sinai, where she worked on developing brain tumors and stereotactic clinical programs. She is the director of the comprehensive tumor program and co-director of the radiosurgery program there. She has worked in the field of image-guided brain and spine surgery[4]. Since cca. 2004, she directed a practical course for neurosurgeons around the world in order to help these tehnological advances become the standard of care. These technologies are used to perform minimally invasive surgery for patients with brain tumors, epilepsy, Parkinson's disease, movement disorders, and spine disease or tumors. She also established a basic science laboratory within the neurosurgery department to focus on brain tumor translational research with particular emphases on gene therapy, stem cells, and induced pluripotent stem cells (iPSC).[5]
Germano IM (Editor). Advanced Techniques in Image-Guided Brain and Spine Surgery. 2002, Thieme Publishers, New York, NY, pages 233 Library of Congress ISBN1-58890-067-3
Germano IM (Editor). LINAC and Gamma Knife Radiosurgery. American Association of Neurological Surgeons Press, Park Ridge, IL, pages 295. Library of Congress ISBN1879284707
Germano IM (Editor). Neurosurgery Treatment of Movement Disorders. American Association of Neurological Surgeons Press, Park Ridge, IL, pages 275 Library of Congress ISBN9781879284586[12]
Mormone E, D'Souza S, Alexeeva V, Bederson M, Germano IM. "Footprint-free" human induced Pluripotent Stem Cell-derived astrocytes for in vivo cell-based therapy. Stem Cells and Dev [in press 2014]. PMID24914471
Lo SS, Gore EM, Bradley JD, Buatti JM, Germano IM, Ghafoori AP, Henderson MA, Murad GJ, Patchell RA, Patel SH, Robbins JR, Robins HI, Vassil AD, Wippold FJ 2nd, Yunes MJ, Videtic GM. ACR Appropriateness Criteria® Pre-Irradiation Evaluation and Management of Brain Metastases. J Palliat Med. 2014 Jun 27.
Germano IM and Binello E. Stem cells and gliomas: past, present, and future. J Neuro-Oncology [in press, 2014].
Binello E, Emdad l, Mormone E, Germano IM. Characterization of fenofibrate-mediated anti-proliferative pro-apoptotic effects on high-grade glioma and anti-invasive effects on glioma stem cells. J Neurooncol, 117(2):225-34, 2014. PMID24493576
Barthélemy EJ, Benjamin E, Jean-Pierre MY, Poitevien G, Ernst S, Osborn I, Germano IM. A prospective emergency department-based study of pattern and outcome of neurologic and neurosurgical diseases in Haiti. World Neurosurg. Oct 9. S1878-8750(13)01298-9, 2013 PIMD 24121294
Binello E, Qadeer ZA, Kothari H, Emdad L,Germano IM. Stemness of the CT-2A Immunocompetent Mouse Brain Tumor Model: Characterization in Vitro. Journal of Cancer, 3:166-174, 2012. PMID22514559
Binello E, Germano IM. Stem cells as therapeutic vehicles for the treatment of high-grade gliomas. Neuro Oncol, 14:256-265, 2012. PMID22166262
Emdad L, D'Souza, Qadeer ZA, Kothari HP, Germano IM. Efficient Differentiation of Human Embryonic and induced pluripotent Stem Cells into Functional Astrocytes. Stem Cells and Development, 21(3):404-4120, 2012. PMID21631388
Patel S, Robbins JR, Gore EM, Bradley JD, Gaspar LE, Germano IM, et al. ACR Appropriateness Criteria: Follow-up and Retreatment of Brain Metastasis. Am J Clin Oncology, 35(3):302-306, 2012. PMID22609733
Binello E and Germano IM. Targeting glioma stem cells: a novel framework for brain tumors. Cancer Sci, 102:1958-1966, 2011. PMID21848914
Binello E, Green S, Germano IM. Radiosurgery for high-grade glioma. Surg Neurol Int, 3(S2) 118-126, 2012. PMID22826815
Patel S, Robbins JR, Gore EM, Bradley JD, Gaspar LE, Germano IM, et al. ACR Appropriateness Criteria Follow-up and Retreatment of Brain Metastasis. Am J Clin Oncology, 2012 Jun;35(3):302-306. PMID22609733
Emdad L, Qadeer ZA, Bederson LB, Kothari HP, Uzzaman M, Germano IM. Is there a common upstream link for autophagic and apoptotic cell death in human high-grade gliomas? Neuro-Oncology, 13(7)725-35, 2011. PMID21727211
Germano IM, Emdad l, Qader Z, Binello E, Uzzaman M. Embryonic stem cell (ESC) –mediated transgene delivery induces growth suppression, apoptosis, radiosensitization, and overcomes temozolomide resistance in malignant gliomas. Cancer Gene Therapy 17(9):664 – 74, 2010. PMID20523363.
Germano IM, Swiss V, Casaccia P. Primary brain Tumors, Neural stem cells, and brain tumor cancer cells: where is the link? Neuropharmacology 58(6):903-10, 2010 PMID20045420
Germano IM and Binello E. Gene therapy as an adjuvant treatment of malignant gliomas: from bench to bedside. J Neuro-Oncology 93:79-87, 2009. PMID19430884
Binello E, Germano IM. Tonsillary carcinoma after temozolomide treatment for glioblastoma multiforme: treatment-related or dual-pathology? J Neuro-Oncol 94(1): 145-8, 2009. PMID19199004
Uzzaman M, Keller G, Germano IM. In vivo Gene Delivery by embryonic stem cell-derived astrocytes for malignant gliomas. Neuro-Oncology, 11:102-108 2009. PMID18676359
Videtic GMM, Gaspar LE, Aref AM, Germano IM, Goldsmith BJ, Imperato JP, Marcus KJ, McDermott MW, McDonald MW, Patchell RA, Robins HI, Rogers CL, Suh JH, Wolfson AH, Wippold FJ. American College of Radiology appropriateness criteria on multiple brain metastases. J Rad Oncol Biol Physics 75:961-965, 2009. PMID19857783
Germano IM, Uzzaman M, Keller G. Gene delivery by embryonic stem cells for malignant glioma therapy: hype or hope? Cancer Biology and Therapy 7(9): 1341-7, 2008. PMID1879364
Benzil D, Abosch A, Germano IM, Gilmer Holy, Maraire N, Muraszko K, Pannullo S, Rosseau G, Schwartz L, Todor, R, Ullman J, Zusman E. The future of neurosurgery: a white paper on the recruitment and retention of women in neurosurgery. J Neurosurgery 109: 367-375, 2008. PMID18759565
Uzzaman M, Keller G, Germano IM. Enhanced pro-apoptotic effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on temozolomide-resistant glioma cells. J Neurosurgery 106: 646-651, 2007. PMID17432717
Germano IM, Uzzaman M, Benveniste R, Zaurova M, Keller G. Apoptosis in human glioma cells produced using embryonic stem cell-derived astrocytes expressing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Neurosurgery 105:88-95, 2006. PMID16871882
Uzzaman M, Benveniste R, Keller G,Germano IM. Embryonic stem cell-derived astrocytes: novel gene therapy vector for brain tumors. Neurosurgical Focus 19(3) E6, 2005. PMID16190605
Benveniste R, Keller G, Germano IM. Embryonic stem cell-derived astrocytes expressing drug-inducible transgenes: Differentiation and allotransplantation into the mouse brain. J Neurosurgery 103:115-123,2005. PMID16121982
Benveniste R. and Germano IM. Correlation of factors predicting intraoperative brain shift with successful resection of malignant brain tumors using image-guided techniques. Surg Neurol 63:542-549, 2005. PMID15936381
Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y, Kondo S. Arsenic trioxide induces autophagic cell death in malignant glioma cells by up-regulation of mitochondrial cell death protein BNIP3. Oncogene 24: 980-91, 2005. PMID15592527
Germano IM,Gracies JM, Weisz DJ,Tse W,Koller WC, Olanow CW. Unilateral stimulation of the subthalamic nucleus in Parkinson's disease- a double-blind 12-month evaluation study. J Neurosurgery 101:36-42, 2004. PMID15255249
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