In February 2025, the hospital was ranked 19th among over 2,400 hospitals in the world and the best hospital in New York state by Newsweek.[5] Adjacent to the hospital is the Mount Sinai Kravis Children's Hospital which provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults aged 0–21 throughout the region.[6][7]
History
Early years
At the time of the founding of the hospital in 1852, other hospitals in New York City discriminated against Jewish people by either not hiring doctors or nurses to treat patients and by prohibiting them from being treated in the hospitals' wards.[8]Orthodox Jewish philanthropist Sampson Simson (1780–1857) founded the hospital to address the needs of New York City's rapidly growing Jewishimmigrant community. It was the second Jewish hospital in the United States, after the Jewish Hospital, located in Cincinnati, Ohio, which was established in 1847.[9]
The Jews' Hospital in the City of New York, as it was called until adopting its current name in 1866,[10] was built on West 28th Street in Manhattan, between Seventh and Eighth Avenues, on land donated by Simson. It opened two years before Simson's death. Four years later, it was unexpectedly filled to capacity with soldiers injured in the American Civil War.[11][12]
The Jews' Hospital felt the effects of the escalating Civil War in other ways, as staff doctors and board members were called into service. Dr. Israel Moses served four years as lieutenant colonel in the 72nd New York Infantry Regiment;[13]Joseph Seligman had to resign as a member of the board of directors, as he was increasingly called upon by President Lincoln for advice on the country's growing financial crisis.[14][15]
The New York Draft Riots of 1863 also strained the hospital's resources, as it struggled to tend to the many wounded.
The hospital in 1893
More and more, the Jews' Hospital was finding itself an integral part of the general community. In 1866, to reflect this new-found role, it changed its name to Mount Sinai Hospital. In 1872, the hospital moved uptown to the east side of Lexington Avenue between East 66th and 67th streets.[16][17]
20th century
Now called Mount Sinai Hospital, the institution forged relationships with many physicians who made contributions to medicine, including Henry N. Heineman, Frederick S. Mandelbaum, Bernard Sachs, Charles A. Elsberg, Emanuel Libman, and, most significantly, Abraham Jacobi, known as the father of American pediatrics and a champion of construction at the hospital's new site on Manhattan's Upper East Side in 1904.[18]
The hospital with proposed buildings map in 1916
The hospital established a school of nursing in 1881. Created by Alma deLeon Hendricks and a small group of women, Mount Sinai Hospital Training School for Nurses was taken over by the hospital in 1895. In 1923, its name was changed to Mount Sinai Hospital School of Nursing. This school closed in 1971 after graduating 4,700 women and one man in the last class. An active alumnae association continues to exist. Since 2013, the nursing school of the Mount Sinai Health System has been called Mount Sinai Phillips School of Nursing (PSON).[19]
The hospital pictured in a 1920 postcard
The early 20th century saw the population of New York City explode. That, coupled with many new discoveries at Mount Sinai (including significant advances in blood transfusions and the first endotracheal anesthesia apparatus), meant that Mount Sinai's pool of doctors and specialists was in increasing demand. A $1.35 million ($47,200,000 in current dollar terms) expansion of the 1904 hospital site raced to keep pace with demand. The opening of the new buildings was delayed by the advent of World War I. Mount Sinai responded to a request from the United States Army Medical Corps with the creation of Base Hospital No.3. This unit went to France in early 1918, and treated 9,127 patients with 172 deaths: 54 surgical and 118 medical, the latter due mainly to influenza and pneumonia.
World War II
Two decades later, with tensions in Europe escalating, a committee dedicated to finding placements for doctors fleeing Nazi Germany was founded in 1933. With the help of the National Committee for the Resettlement of Foreign Physicians, Mount Sinai Hospital became a new home for a large number of émigrés. When World War II broke out, Mount Sinai was the first hospital to throw open its doors to Red Cross nurses' aides; the hospital trained many in its effort to reduce the nursing shortage in the United States. Meanwhile, the president of the medical board, George Baehr, M.D., was called by President Roosevelt to serve as the nation's chief medical director of the Office of Civilian Defense.[20]
These wartime roles were eclipsed, however, when the men and women of Mount Sinai's 3rd General Hospital set sail for Casablanca, Morocco, eventually setting up a 1,000-bed hospital in war-torn Tunisia. Before moving to tend to the needs of soldiers in Italy and France, the 3rd General Hospital had treated more than 5,000 wounded soldiers.[21]
Postwar
The Icahn Medical Institute at 1425 Madison Avenue, built in 1997
Among the innovations at Mount Sinai were performing the first blood transplant into the vein of a fetus in 1986, and the development of a technique for inserting radioactive seeds into the prostate to treat cancer in 1995.[22]
21st century
Milestones
2000s
At Mount Sinai the staff performed the first successful composite tracheal transplant, which was performed at the hospital in 2005.
First gene variant linked to autism identified.[23]
Zahi Fayad, PhD, and Valentin Fuster, MD, PhD, develop a technique called “black blood MRI” to detect vulnerable arterial plaque.[24]
Bruce Gelb, MD, with collaborators, co-discovers that mutations in PTPN11 cause Noonan syndrome, inaugurating the Ras/MAPK “RASopathies” disease family.[26]
Fabrazyme approved by FDA to treat Fabry disease, developed by Robert Desnick, PhD, MD, David Bishop, PhD, and Yiannis Ioannou, PhD.[27]
First successful composite tracheal transplant is performed by Eric Genden, MD, using tissue from a donor and the recipient.[28]
Advanced imaging of leukocyte microdomains (white blood cell movement) developed.[32]
Standard definitions for bleeding in trials established by Roxana Mehran, MD.[33]
2010s
In January 2013 David L. Reich was the first openly gay medical doctor named interim president of Mount Sinai Hospital as reported by The New York Times.[34] In October of the same year he was named president.[35][36]
Mechanism for a Parkinson’s gene mutation uncovered.[37]
Vivek Reddy, MD implanted the first U.S. leadless cardiac pacemaker (St. Jude/Abbott Nanostim), launching the LEADLESS II pivotal trial.[38]
First U.S. use of an FDA-approved drug-coated balloon for leg arteries.[39]
Saadi Ghatan, MD, and team implant the NeuroPace RNS® system in a 14-year-old—then the youngest patient treated with this device—helping establish pediatric use of RNS for drug-resistant epilepsy.[40]
May, 20215 Kidney Stone Center opens for advanced and preventive care.
First HIV-positive–to–HIV-positive organ transplant in New York State, performed by Sander Florman, MD, and Susan Lerner, MD.[41]
First tau-PET pattern of CTE reported in a living person. reavealing a CTE-typical tau pattern in a former NFL player—an early step toward in-life detection of the disease.[42]
Immune map of eczema by Emma Guttman, MD, PhD, and colleagues guides a breakthrough therapy.[43]
Two strains of human herpesvirus are found in the brains of people with Alzheimer’s disease at levels up to twice as high as in those without Alzheimer’s, as shown by Joel Dudley, PhD, and Samuel Gandy, MD, PhD.[44]
2020s
Dr. David Reich, president and COO of the hospital, announced in March 2020 that the hospital was converting its lobbies into extra patient rooms to "meet the growing volume of patients" that contracted COVID-19.[45][46]
Florian Krammer, PhD, and Viviana Simon, MD, PhD, lead a team that develops, validates, and launches a test that detects the quantity as well as the presence or absence of antibodies to SARS-CoV-2.[47]
Common prostate cancer gene fusion identified, ransforming diagnosis and research into disease subtypes.[48]
Gustave L. Levy Stroke Unit earns certification as Comprehensive Stroke Center.[49]
Lauren Singelakis, Women We Admire's Top 50 Women Leaders in Medicine for 2025[67]
Controversies
Dr. Jack M. Gorman, formerly Department Chairman of Psychiatry at Mount Sinai, engaged in a long-term inappropriate sexual relationship with a patient prior to October 2005.[68]
In August 2016, Dennis S. Charney, then dean of the medical school, was shot and wounded as he left a deli in his home town of Chappaqua, New York. Hengjun Chao, a former Mount Sinai medical researcher who had been fired by Charney for research misconduct in 2010, was convicted of attempted second degree murder and two other charges in 2017, and received a sentence of 28 years.[69][70][71][72]
In 2017, Dr. David H. Newman, a former emergency room physician at Mount Sinai Hospital, was sentenced to two years in prison for sexually abusing four female patients in the emergency room between 2015 and 2016, including touching their breasts.[73][74]
Three doctors were convicted of violating anti-kickback laws by accepting bribes disguised as speaker fees to write prescriptions to a highly addictive fentanylopioid painkiller. Gordon Freedman, an anesthesiologist at Mount Sinai, was convicted in December 2019 in Manhattan federal court.[75][76][77] Alexandru Burducea, a pain management doctor and anesthesiologist who previously worked at Mount Sinai, was sentenced in January 2020 to 57 months in prison.[75][76][77] Dialecti Voudouris, who specialized in oncology and hematology at Lenox Hill Hospital and Mount Sinai, was sentenced in 2020 to time served.[78][79]
In April 2019, a lawsuit was filed against Mount Sinai Health System and several employees of the hospital and the Icahn School's Arnhold Institute for Global Health.[80] The suit was filed by eight current and former doctors and employees for alleged age and sex discrimination and based on a list of other allegations.[81] The school denied the claims.[80]
Mount Sinai Kravis Children's Hospital (KCH) at Mount Sinai is a nationally ranked pediatric acute care children's hospital located at the Mount Sinai campus in Manhattan, New York City, New York. The hospital has 102 pediatric beds.[82] It is affiliated with The Icahn School of Medicine at Mount Sinai, and is a member of the Mount Sinai Health System. The hospital provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults aged 0–21 throughout the region.[6][7]
Employment
As of 2025, the entire Mount Sinai Health System had over 9,000 physicians, 2,700 residents and clinical fellows, and 48,000 employees, as well as 3,221 beds and 140 operating rooms, and delivered over 13,940 babies a year.[83]
In March 2025, the hospital was ranked 19th among over 2,400 hospitals in the world and the best hospital in New York state by Newsweek.[86]
Mount Sinai's logo prior to 2012
In 2025-2026, Mount Sinai Hospital was recognized on the U.S. News & World Report "Best Hospitals Honor Roll," with multiple specialties ranked in the top 20 nationwide (cardiology #2, geriatrics #3, gastroenterology #5, cancer #6, urology #6, neurology & neurosurgery #11, orthopedics #14, obstetrics & gynecology #17, diabetes & endocrinology #19).[87]
Notable individuals
Benefactors
Leon Black donated $10 million in 2005 to create the Black Family Stem Cell Institute.[88]
Emily and Len Blavatnik made a $10 million gift in 2018 to establish The Blavatnik Family Women's Health Research Institute at the Icahn School of Medicine at Mount Sinai and The Blavatnik Family – Chelsea Medical Center at Mount Sinai.[89]
Carl Icahn donated $25 million to Mount Sinai Medical Center for advanced medical research in 2004; a large building primarily devoted to research was renamed from the "East Building" to the "Icahn Medical Institute."[90][91] In 2012, Icahn pledged $200 million to the institution.[92] In exchange, the medical school was renamed the Icahn School of Medicine at Mount Sinai and the genomics institute led by Eric Schadt was renamed the Icahn Institute for Genomics and Multiscale Biology.
Frederick Klingenstein, former CEO of Wertheim & Co., and wife Sharon Klingenstein donated $75 million in 1999 to the medical school, the largest single gift in the history of Mount Sinai medical school at the time, to establish an institute for scientific research and create a scholarship fund.[93]
Henry Kravis and wife Marie-Josée Kravis donated $15 million to establish the "Center for Cardiovascular Health" as well as funding a professorship.
Samuel A. Lewis, NYC political leader and philanthropist who served for 21 years (1852–1873) as the first director, then honorary secretary, and finally chairman of the executive committee.
Hermann Merkin gave $2 million in dedication of the kosher kitchen at the hospital.
Derald Ruttenberg donated $7 million in 1986 to establish the Ruttenberg Cancer Center at Mount Sinai and later contributed $8 million more.[94]
Martha Stewart donated $5 million in 2007 to start the Martha Stewart Center for Living at Mount Sinai Hospital. The center promotes access to medical care and offers support to caregivers needing referrals or education.[95]
James Tisch and wife Merryl Tisch donated $40 million in 2008 to establish The Tisch Cancer Institute, a state-of-the-art, patient-oriented comprehensive cancer care and research facility.[96][97]
Valentín Fuster (born 1943), director of Mount Sinai Heart, The Zena and Michael A. Wiener Cardiovascular Institute, The Marie-Josée and Henry R. Kravis Center for Cardiovascular Health, The Richard Gorlin, MD/Heart Research Foundation Professor, Icahn School of Medicine at Mount Sinai.
Eric M. Genden, Isidore Friesner Professor and Chair of Otolaryngology – Head and Neck Surgery, Senior Associate Dean for Clinical Affairs, and Professor of Neurosurgery and Immunology at the Icahn School of Medicine at Mount Sinai. He is Chair of Otolaryngology – Head and Neck Surgery, Executive Vice President of Ambulatory Surgery, and Director of the Head and Neck Institute at the Mount Sinai Health System. Named one of the most innovative surgeons alive today, in 2006 he became the first surgeon ever to perform a successful jaw transplant.
Irving B. Goldman (1898–1975), first president of the American Academy of Facial Plastic and Reconstructive Surgery, 1964.
Jonathan L. Halperin (born 1949), director of Clinical Cardiology in the Zena and Michael A. Wierner Cardiovascular Institute.
Michael Heidelberger (1888–1991), immunologist regarded as the father of modern immunology.
Eimear Kenny, known for novel approaches to computational genomics that examine human genetic variation and its link to disease, thereby laying the groundwork for integrating AI and genomics into routine clinical care.
Helen S. Mayberg (born 1956), founding director of the Center for Advanced Circuit Therapeutics.
John Puskas, performed the first totally thoracoscopic bilateral pulmonary vein isolation procedure.[103]
David L. Reich, academic anesthesiologist, president and chief operating officer of Mount Sinai, chair of the department of anesthesiology, Horace W. Goldsmith Professor of Anesthesiology.
Jonas Salk (1914–1995), inventor of the polio vaccine, worked as a staff physician at Mount Sinai after medical school.[104]
Milton Sapirstein (1914–1996), clinical psychiatrist. Sought "to mesh the advances being made in neurobiology in the 1940s with psychoanalytic concepts."[105]
Samin Sharma (born 1955), interventional cardiologist, co-founder of the Eternal Heart Care Centre and Research Institute, Jaipur, and director, Dr. Samin K. Sharma Family Foundation Cardiac Catheterization Laboratory.
↑ Communications, Emmis (May 25, 2019). "Cincinnati Magazine". Emmis Communications. Archived from the original on October 30, 2023. Retrieved October 27, 2020– via Google Books.
↑ US5401650A,Desnick, Robert J.; Bishop, David F.& Ioannou, Yiannis A.,"Cloning and expression of biologically active α-galactosidase A",issued March 28, 1995
↑ Genden, Eric M.; Miles, Brett A.; Harkin, Timothy J.; DeMaria, Samuel; Kaufman, Andrew J.; Mayland, Erica; Kaul, Vivian F.; Florman, Sander S. (October 2021). "Single-stage long-segment tracheal transplantation". American Journal of Transplantation: Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 21 (10): 3421–3427. doi:10.1111/ajt.16752. ISSN1600-6143. PMID34236746.
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