JYQ-42

Last updated

JYQ-42
JYQ-42 structure.png
Clinical data
Drug class Sirtuin-6 (SIRT6) inhibitor
Identifiers
  • 1-(4-amino-1,2,5-oxadiazol-3-yl)-N-[(E)-[3-chloro-5-(trifluoromethyl)phenyl]methylideneamino]triazole-4-carboxamide
CAS Number
PubChem CID
Chemical and physical data
Formula C13H8ClF3N8O2
Molar mass 400.71 g·mol−1
3D model (JSmol)
  • C1=C(C=C(C=C1C(F)(F)F)Cl)/C=N/NC(=O)C2=CN(N=N2)C3=NON=C3N
  • InChI=1S/C13H8ClF3N8O2/c14-8-2-6(1-7(3-8)13(15,16)17)4-19-21-12(26)9-5-25(24-20-9)11-10(18)22-27-23-11/h1-5H,(H2,18,22)(H,21,26)/b19-4+
  • Key:YUEMOICLRSWFIT-RMOCHZDMSA-N

JYQ-42 is a drug which acts as a sirtuin-6 (SIRT6) inhibitor. It has potential applications in cancer treatment, having been found to inhibit the migration of pancreatic cancer cells and thereby reduce tumor invasiveness. [1] [2]

References

  1. Zhang Q, Chen Y, Ni D, Huang Z, Wei J, Feng L, et al. (2022). "Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells". Acta Pharmaceutica Sinica B. 12 (2): 876–889. doi:10.1016/j.apsb.2021.06.015. PMC   8897208 . PMID   35256952.
  2. Chouhan S, Kumar A, Muhammad N, Usmani D, Khan TH (2024). "Sirtuins as Key Regulators in Pancreatic Cancer: Insights into Signaling Mechanisms and Therapeutic Implications". Cancers. 16 (23): 4095. doi: 10.3390/cancers16234095 . PMC   11640239 . PMID   39682281.