Jacques Banchereau

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Jacques Banchereau
Alma materUniversity of Angers (BS) University of Paris (PhD)
Known forDendritic Cells
AwardsAAI-Steinman Award
Scientific career
FieldsBiochemistry, Immunology, Molecular Biology

Jacques Banchereau is an internationally prominent French American immunologist and molecular biologist. As of 2024, he is Chief Scientific Officer at Javelin Biotech. [1] He was formerly professor and director of immunological sciences at the Jackson Laboratory for Genomic Medicine and also the former chief science officer, senior vice president, and DTA (Discovery and Translational Area) head of inflammation & virology at Hoffman-La Roche. [2] He is best known for his extensive research on dendritic cells [3] with Nobel Laureate Ralph M. Steinman. He is the fifth most cited immunologist ranked by Times Higher Education's report. [4]

Contents

Experience

Banchereau was born in France. He graduated from University of Angers as a pharmacist in 1975. He completed his PhD study in biochemistry from University of Paris in 1980. Then he completed his post-doctorate study at Columbia University. [5] During his PhD and post-doctorate time, he was involved with the discovery and functional analysis of GM-CSF, IL-4, IL-5, IL-10, IL-13, and IL-17. [6] After his time at Columbia, he started his career as a scientist at Schering-Plough France in 1981, and quickly rose to the post of director for immunological research in 1984. In 1996, he left the company to found the Baylor Institute for Immunology Research. [5] He served as adjunct professor at UT Southwestern Medical Center, and is now adjunct professor at Mount Sinai School of Medicine, Texas A&M University College of Dentistry, and Baylor University. [2] In 2010, he joined Hoffman-La Roche at Nutley to become the chief scientific officer, senior vice president, and head of inflammation and virology. In 2012, he accepted the invitation from the Jackson Laboratory to be appointed as director of immunological sciences.

Research

In addition to Banchereau's contribution on discovery of multiple interluekins and understanding them, his most well-known researches include the dendritic cells and vaccines. While Ralph M. Steinman discovered the dendritic cells, Banchereau was one of the first to find a way to grow them. His major work on dendritic cells include cancer vaccines and immunotherapy. [7] He is the author of more than 300 peer-reviewed scientific articles and about 275 book chapters and reviews. He also holds 41 patents. [5] His current research interest is on understanding RNA splicing for receptors.

Works

Related Research Articles

<span class="mw-page-title-main">Dendritic cell</span> Accessory cell of the mammalian immune system

A dendritic cell (DC) is an antigen-presenting cell of the mammalian immune system. A DC's main function is to process antigen material and present it on the cell surface to the T cells of the immune system. They act as messengers between the innate and adaptive immune systems.

<span class="mw-page-title-main">CD40 (protein)</span> Mammalian protein found in humans

Cluster of differentiation 40, CD40 is a type I transmembrane protein found on antigen-presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.

<span class="mw-page-title-main">Follicular dendritic cells</span> Immune cells found in lymph nodes

Follicular dendritic cells (FDC) are cells of the immune system found in primary and secondary lymph follicles of the B cell areas of the lymphoid tissue. Unlike dendritic cells (DC), FDCs are not derived from the bone-marrow hematopoietic stem cell, but are of mesenchymal origin. Possible functions of FDC include: organizing lymphoid tissue's cells and microarchitecture, capturing antigen to support B cell, promoting debris removal from germinal centers, and protecting against autoimmunity. Disease processes that FDC may contribute include primary FDC-tumor, chronic inflammatory conditions, HIV-1 infection development, and neuroinvasive scrapie.

<span class="mw-page-title-main">CD80</span> Mammalian protein found in humans

The Cluster of differentiation 80 is a B7, type I membrane protein in the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding. It is closely related to CD86, another B7 protein (B7-2), and often works in tandem. Both CD80 and CD86 interact with costimulatory receptors CD28, CTLA-4 (CD152) and the p75 neurotrophin receptor.

<span class="mw-page-title-main">Ralph M. Steinman</span> Canadian immunologist and cell biologist

Ralph Marvin Steinman was a Canadian physician and medical researcher at Rockefeller University, who in 1973 discovered and named dendritic cells while working as a postdoctoral fellow in the laboratory of Zanvil A. Cohn, also at Rockefeller University. Steinman was one of the recipients of the 2011 Nobel Prize in Physiology or Medicine.

Zanvil Alexander Cohn was a cell biologist and immunologist who upon his death was described by The New York Times as being "in the forefront of current studies of the body's defenses against infection.", professor at Rockefeller University. There Cohn had been the Henry G. Kunkel Professor for seven years. Cohn was senior physician at the university as well as vice president for medical affairs. Until two years before his death, he also served as principal investigator of the Irvington Institute for Medical Research. Although Cohn never won the Nobel Prize, Ralph M. Steinman, with whom he ran a laboratory at Rockefeller University for many years, was named to win the 2011 Nobel Prize in Physiology or Medicine for the work on dendritic cells done in their lab, eighteen years after Cohn's death.

Paola Ricciardi-Castagnoli is an Italian immunologist based in Siena. Paola is the scientific director of Toscana Life Sciences Foundation (TLS) in Siena. She was former scientific director of the Singapore Immunology Network (SIgN).

<span class="mw-page-title-main">James P. Allison</span> American immunologist and Nobel laureate (born 1948)

James Patrick Allison is an American immunologist and Nobel laureate who holds the position of professor and chair of immunology and executive director of immunotherapy platform at the MD Anderson Cancer Center in Houston, Texas. Allison is Regental Professor and Founding-Director of James P. Allison Institute at the MD Anderson Cancer Center.

Kayo Inaba is a professor at Kyoto University where she heads the Graduate School of Biostudies. She is also the Vice-President for Gender Equality and the Director of the Centre for Women Researchers.

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Michel C. Nussenzweig is a professor and head of the Laboratory of Molecular Immunology at The Rockefeller University and a Howard Hughes Medical Institute investigator. He is a member of both the US National Academy of Medicine and the US National Academy of Sciences.

The dendritic cell-based cancer vaccine is an innovation in therapeutic strategy for cancer patients.

Seung-Yong Seong is a South Korean immunologist and microbiologist known for his study of innate immune system response and his development of the damage-associated molecular pattern (DAMP) model of immune response initiation in collaboration with Polly Matzinger. Seong is also known for his research on the bacterium Orientia tsutsugamushi and his research on immunological adjuvant when he was a student. Since 2013 he has served as Director of the Wide River Institute of Immunology – Seoul National University in conjunction with his Professor position in the Microbiology and Immunology department of Seoul National University College of Medicine. In 2012, he became Editor in Chief of the World Journal of Immunology.

<span class="mw-page-title-main">Franca Ronchese</span> Italian-New Zealand immunologist

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<span class="mw-page-title-main">Dipyaman Ganguly</span>

Dipyaman Ganguly is an Indian physician-scientist immunologist and cell biologist, currently a Principal Scientist and Swarnajayanthi Fellow at the CSIR-Indian Institute of Chemical Biology (IICB). He heads the Dendritic Cell Laboratory of IICB, popularly known as the Ganguly Lab, where he hosts several researchers involved in research on regulation of innate Immunity and pathogenesis of inflammatory disorders. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards for his contributions to Medical Sciences in 2022.

Miram Merad is a French-Algerian professor in Cancer immunology and the Director of the Marc and Jennifer Lipschultz Precision Immunology Institute (PrIISM) at the Icahn School of Medicine at Mount Sinai (ISMMS) in New York, NY. She is the corecipient of the 2018 William B. Coley Award for Distinguished Research in Basic Immunology and a member of the United States National Academy of Sciences and the National Academy of Medicine.

Sebastian Amigorena is an Argentine immunologist and a Team Leader at the Institut Curie.

Gail A. Bishop is an American professor of microbiology and immunology at the University of Iowa and director of the Center for Immunology & Immune-Based Diseases at the Carver College of Medicine.

Cornelis Joseph Maria Melief is a Dutch immunologuist specialising in cancer immunology and immunotherapy, with a focus on therapeutic cancer vaccines. He is emeritus Professor, former head of the Department of Immunohematology and Blood Transfusion at the Leiden University Medical Center, and Chief Scientific Officer at ISA Therapeutics in Netherlands. He is known for his work in the field of cancer immunology, devising new cancer therapies based on the activation of the patient's own immune system.

<span class="mw-page-title-main">Moriya Tsuji</span> American academic (born 1958)

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References

  1. ↑ https://www.businesswire.com/news/home/20240417237133/en/Jacques-Banchereau-PhD-Appointed-as-Chief-Scientific-Officer-at-Javelin-Biotech.{{cite web}}: Missing or empty |title= (help)
  2. 1 2 "Jacques Banchereau, Ph.D." The Jackson Laboratory. Retrieved 2018-12-09.
  3. ↑ Steinman, Ralph M.; Banchereau, Jacques (March 1998). "Dendritic cells and the control of immunity". Nature. 392 (6673): 245–252. Bibcode:1998Natur.392..245B. doi:10.1038/32588. ISSN   1476-4687. PMID   9521319. S2CID   4388748.
  4. ↑ "Top scientists in immunology by total citations". Times Higher Education (THE). 2009-02-12. Retrieved 2018-12-09.
  5. 1 2 3 Peterson, Joyce. "Jacques Banchereau, Ph.D., appointed director of immunological sciences at The Jackson Laboratory". The Jackson Laboratory. Retrieved 2018-12-17.
  6. ↑ Maxmen, Amy (2009-08-03). "Jacques Banchereau: On a quest for cures". The Journal of Experimental Medicine. 206 (8): 1640–1641. doi:10.1084/jem.2068pi. ISSN   0022-1007. PMC   2722176 . PMID   19652019.
  7. ↑ Palucka, A. Karolina; Banchereau, Jacques (April 2005). "Dendritic cells as therapeutic vaccines against cancer". Nature Reviews Immunology. 5 (4): 296–306. doi:10.1038/nri1592. ISSN   1474-1741. PMID   15803149. S2CID   1037012.
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