Jacques Banchereau

Last updated
Jacques Banchereau
Alma materUniversity of Angers (BS) University of Paris (PhD)
Known forDendritic Cells
AwardsAAI-Steinman Award
Scientific career
FieldsBiochemistry, Immunology, Molecular Biology

Jacques Banchereau is an internationally prominent French American immunologist and molecular biologist. As of 2018, he is professor and director of immunological sciences at the Jackson Laboratory for Genomic Medicine. He was also the former chief science officer, senior vice president, and DTA (Discovery and Translational Area) head of inflammation & virology at Hoffman-La Roche. [1] He is best known for his extensive research on dendritic cells [2] with Nobel Laureate Ralph M. Steinman. He is the fifth most cited immunologist ranked by Times Higher Education's report. [3]

Contents

Experience

Banchereau was born in France. He graduated from University of Angers as a pharmacist in 1975. He completed his PhD study in biochemistry from University of Paris in 1980. Then he completed his post-doctorate study at Columbia University. [4] During his PhD and post-doctorate time, he was involved with the discovery and functional analysis of GM-CSF, IL-4, IL-5, IL-10, IL-13, and IL-17. [5] After his time at Columbia, he started his career as a scientist at Schering-Plough France in 1981, and quickly rose to the post of director for immunological research in 1984. In 1996, he left the company to found the Baylor Institute for Immunology Research. [4] He served as adjunct professor at UT Southwestern Medical Center, and is now adjunct professor at Mount Sinai School of Medicine, Texas A&M University College of Dentistry, and Baylor University. [1] In 2010, he joined Hoffman-La Roche at Nutley to become the chief scientific officer, senior vice president, and head of inflammation and virology. In 2012, he accepted the invitation from the Jackson Laboratory to be appointed as director of immunological sciences.

Research

In addition to Banchereau's contribution on discovery of multiple interluekins and understanding them, his most well-known researches include the dendritic cells and vaccines. While Ralph M. Steinman discovered the dendritic cells, Banchereau was one of the first to find a way to grow them. His major work on dendritic cells include cancer vaccines and immunotherapy. [6] He is the author of more than 300 peer-reviewed scientific articles and about 275 book chapters and reviews. He also holds 41 patents. [4] His current research interest is on understanding RNA splicing for receptors.

Works

Related Research Articles

Dendritic cell specialized cells of the hematopoietic system with branch-like extensions

Dendritic cells (DCs) are antigen-presenting cells of the mammalian immune system. Their main function is to process antigen material and present it on the cell surface to the T cells of the immune system. They act as messengers between the innate and the adaptive immune systems.

Polly Matzinger American immunologist

Polly Celine Eveline Matzinger is an immunologist who proposed the danger model theory of how the immune system works. In 2002, Discover magazine recognized Matzinger as one of the 100 most important women in science.

Timeline of immunology:

Follicular dendritic cells (FDCs) are cells of the immune system found in primary and secondary lymph follicles of the B cell areas of the lymphoid tissue. Unlike DCs, FDCs are not derived from the bone-marrow hematopoietic stem cell, but are of mesenchymal origin.

Emil Raphael Unanue (born September 13, 1934) is an immunologist and the current Paul & Ellen Lacy Professor at Washington University School of Medicine. He is a member of the National Academy of Sciences, the American Academy of Arts and Sciences and the Institute of Medicine. He previously served as chair of the National Academy of Sciences Section of Microbiology and Immunology.

Ralph M. Steinman Canadian immunologist and cell biologist

Ralph Marvin Steinman was a Canadian physician and medical researcher at Rockefeller University, who in 1973 discovered and named dendritic cells while working as a postdoctoral fellow in the laboratory of Zanvil A. Cohn, also at Rockefeller University. Steinman was one of the recipients of the 2011 Nobel Prize in Physiology or Medicine.

Cancer immunology

Cancer immunology is an interdisciplinary branch of biology that is concerned with understanding the role of the immune system in the progression and development of cancer; the most well known application is cancer immunotherapy, which utilises the immune system as a treatment for cancer. Cancer immunosurveillance and immunoediting are based on protection against development of tumors in animal systems and (ii) identification of targets for immune recognition of human cancer.

Nicholas P. Restifo is an American immunologist, physician and educator in cancer immunotherapy. Until July 2019, he was a tenured senior investigator in the intramural National Cancer Institute of the National Institutes of Health at Bethesda, Maryland.Nicholas is now the Executive Vice President of Research at Lyell based in San Francisco.

Zanvil Alexander Cohn was a cell biologist and immunologist who upon his death was described by The New York Times as being "in the forefront of current studies of the body's defenses against infection.", professor at Rockefeller University. There Cohn had been the Henry G. Kunkel Professor for seven years. Cohn was senior physician at the university as well as vice president for medical affairs. Until two years before his death, he also served as principal investigator of the Irvington Institute for Medical Research. Although Cohn never won the Nobel Prize, Ralph M. Steinman, with whom he ran a laboratory at Rockefeller University for many years, was named to win the 2011 Nobel Prize in Physiology or Medicine for the work on dendritic cells done in their lab, eighteen years after Cohn's death.

Paola Ricciardi-Castagnoli, is an Italian Immunologist presently Scientific Director of Toscana Life Sciences Foundation (TLS) in Siena and former Scientific Director and founder of the Singapore Immunology Network (SIgN), a research institute of the Agency for Science, Technology and Research (A*STAR).

James P. Allison American immunologist and Nobel laureate (born 1948)

James Patrick Allison is an American immunologist and Nobel laureate who holds the position of professor and chair of immunology and executive director of immunotherapy platform at the MD Anderson Cancer Center at the University of Texas.

Gabrielle Belz Australian immunologist

Gabrielle T. Belz is an Australian molecular immunologist and viral immunologist. She is a faculty member of the Walter and Eliza Hall Institute of Medical Research, within the Molecular Immunology division. Belz has made important contributions to the understanding of immune system function, especially in relation to the molecular and cellular signalling pathways of immune response to viruses. Her research has focused on understanding the signals that drive the initial development of protective immunity against pathogen infections, such as influenza and herpes viruses. This includes research into how cytotoxic T cells recognise and remove virally-infected cells from the body following infection. Research into the description of the specific factors and response during infection will contribute towards the long term development of vaccines for infectious disease, and the development of better treatments for autoimmune diseases.

Kayo Inaba is a Professor at Kyoto University where she heads the Graduate School of Biostudies. She is also the Vice-President for Gender Equality and the Director of the Centre for Women Researchers.

Michel C. Nussenzweig researcher ORCID ID = 0000-0003-0592-8564

Michel C. Nussenzweig is a professor and head of the Laboratory of Molecular Immunology at The Rockefeller University and a Howard Hughes Medical Institute investigator. He is a member of both the US National Academy of Medicine and the US National Academy of Sciences.

Javed Naim Agrewala is an Indian immunologist, the Dean of research at Indian Institute of Technology Ropar and the chief scientist and professor at the Institute of Microbial Technology, Chandigarh. Known for his research on Tuberculosis, Agrewala is an elected fellow of all the three major Indian science academies viz. National Academy of Sciences, India, Indian National Science Academy and Indian Academy of Sciences. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards for his contributions to Medical Sciences in 2005. He is also a recipient of the National Bioscience Award for Career Development of the Department of Biotechnology.

Immunological memory is the ability of the immune system to quickly and specifically recognize an antigen that the body has previously encountered and initiate a corresponding immune response. Generally these are secondary, tertiary and other subsequent immune responses to the same antigen. Immunological memory is responsible for the adaptive component of the immune system, special T and B cells — the so-called memory T and B cells. Immunological memory is the basis of vaccination.

Dendritic cells (DCs) are powerful antigen presenting cells for the induction of antigen specific T cell response. DC vaccine has been introduced as a new therapeutic strategy in cancer patients. DC-based immunotherapy is safe and can promote antitumor immune responses and prolonged survival of cancer patients.

Seung-Yong Seong is a South Korean immunologist and microbiologist known for his study of innate immune system response and his development of the damage-associated molecular pattern (DAMP) model of immune response initiation in collaboration with Polly Matzinger. Seong is also known for his research on the bacterium Orientia tsutsugamushi and his research on immunological adjuvant when he was a student. Since 2013 he has served as Director of the Wide River Institute of Immunology – Seoul National University in conjunction with his Professor position in the Microbiology and Immunology department of Seoul National University College of Medicine. In 2012, he became Editor in Chief of the World Journal of Immunology.

Sebastian Amigorena is an Argentinian-French immunologist and a Team Leader at the Institut Curie.

References

  1. 1 2 "Jacques Banchereau, Ph.D." The Jackson Laboratory. Retrieved 2018-12-09.
  2. Steinman, Ralph M.; Banchereau, Jacques (March 1998). "Dendritic cells and the control of immunity". Nature. 392 (6673): 245–252. Bibcode:1998Natur.392..245B. doi:10.1038/32588. ISSN   1476-4687. PMID   9521319.
  3. "Top scientists in immunology by total citations". Times Higher Education (THE). 2009-02-12. Retrieved 2018-12-09.
  4. 1 2 3 Peterson, Joyce. "Jacques Banchereau, Ph.D., appointed director of immunological sciences at The Jackson Laboratory". The Jackson Laboratory. Retrieved 2018-12-17.
  5. Maxmen, Amy (2009-08-03). "Jacques Banchereau: On a quest for cures". The Journal of Experimental Medicine. 206 (8): 1640–1641. doi:10.1084/jem.2068pi. ISSN   0022-1007. PMC   2722176 . PMID   19652019.
  6. Palucka, A. Karolina; Banchereau, Jacques (April 2005). "Dendritic cells as therapeutic vaccines against cancer". Nature Reviews Immunology. 5 (4): 296–306. doi:10.1038/nri1592. ISSN   1474-1741. PMID   15803149.