James Kang

Last updated
James D. Kang
James K-opt.jpg
Born
Seoul, South Korea
NationalityAmerican
Alma materWashington University in St. Louis, University of Oklahoma College of Medicine
Known forResearch on intervertebral disc degeneration
Scientific career
FieldsOrthopedic Surgery, Spinal Surgery
InstitutionsBrigham and Women's Hospital, Harvard Medical School, University of Pittsburgh

James D. Kang is an American academic, orthopedic surgeon, and scientist, specializing in spinal surgery. He is Chair Emeritus of the Department of Orthopaedic Surgery at Brigham and Women's Hospital (BWH) and holds the Thomas S. Thornhill and Karen N. Thornhill Distinguished Professorship at Harvard Medical School. [1]

Contents

Early life and education

Kang was born in Seoul, South Korea, and immigrated to the United States in 1967. He attended Putnam City High School in Oklahoma City, graduating in 1978. He earned a degree in chemical engineering from Washington University in St. Louis in 1982 and obtained his medical degree from the University of Oklahoma College of Medicine in 1986. Kang completed his orthopedic surgery residency at the University of Pittsburgh School of Medicine in 1992, followed by a fellowship in spine surgery at Case Western Reserve University in 1993 under the direction of Henry Bohlman. [2]

Career

Following his fellowship, Kang joined the faculty of the Department of Orthopaedic Surgery at the University of Pittsburgh School of Medicine, where he was later promoted to full professor and appointed the UPMC Endowed Chair in Orthopaedic Surgery in 2007. [3] He also served as the executive vice chairman for clinical services and director of the Ferguson Laboratory Musculoskeletal Research Center for Spine Research at the University of Pittsburgh Medical Center (UPMC). [4]

In 2015, Kang was appointed chair of the Department of Orthopaedic Surgery at BWH, succeeding Thomas S. Thornhill. [5] In 2016, he received the Thomas and Karen Thornhill Professorship at Harvard Medical School. After a ten-year tenure as chair, he transitioned to chair emeritus and distinguished professor at Harvard Medical School in 2025. [6]

Kang served as President of the American Board of Orthopaedic Surgery for the 2023–2024 term, a role that kept him centrally engaged with issues of board certification, maintenance of certification, and professional standards for orthopaedic surgeons nationwide. As ABOS president he publicly addressed evolving issues such as the responsible use of artificial intelligence in assessment and exam workflows [7] [8]

In 2016, he was also president of the International Society for the Study of the Lumbar Spine. [9]

Research and contributions

Kang has performed research on intervertebral disc degeneration (IDD), focusing on its biological and molecular pathomechanisms. His research established that disc cells are biochemically active, producing inflammatory cytokines that may contribute to back pain and radicular pain. [10] His studies explored the interactions between aging and disc degeneration using animal models, leading to insights into inflammation and matrix degradation in IDD. [11]

Kang also investigated molecular therapies for disc degeneration, including gene therapy. [12] His studies demonstrated the feasibility of gene transfer into the disc and the therapeutic potential of enhancing matrix proteins. Additionally, he has conducted clinical research on spinal disorders, evaluating functional outcomes following cervical, thoracic, and lumbar spinal surgeries. [13]

Kang has performed more than 14,000 spinal surgeries. He has authored over 300 peer-reviewed publications and more than 73 book chapters, as well as authoring a text book on Hip-Spine Syndrome. [14] He has served as deputy editor of Spine as well for the spine section of the Journal of Orthopaedic Research (JOR). [15] [16]

Kang's recent publications underscore his ongoing commitment to advancing spine research and fostering equity in the field. In August 2025, he co-authored Sex Disparities in Spine Surgeon Leadership of Clinical Trials for Degenerative Spine Disease Research, a study assessing the representation of women as principal investigators in spine surgery clinical trials, highlighting persistent underrepresentation and advocating for greater diversity in leadership roles. [17] That same month, he published Shifts in Diversity Along the Spine Surgery Training Pathway, a cross-sectional analysis examining racial, ethnic, and gender diversity among academic orthopedic spine surgeons in the United States, emphasizing the need for improved inclusion throughout the training and professional pipeline. [18]

In 2024, Kang explored translational therapies in Rapamycin Mitigates Inflammation-Mediated Disc Matrix Degradation, investigating the potential of rapamycin to regulate the PI3K/Akt/mTOR signaling pathway and counteract inflammation-induced disc degeneration. [19]

Selected publications

References

  1. "Kang Named Thornhill Family Professor of Orthopedic Surgery | Harvard Medical School". Harvard Medical School . 1 December 2016.
  2. "James Kang | Harvard Catalyst Profiles | Harvard Catalyst". Harvard Medical School .
  3. "James D. Kang, MD - Brigham and Women's Hospital". Brigham and Women's Hospital .
  4. "James D. Kang, MD". bwhneurosciences. 20 June 2017.
  5. "Kang Appointed Chair of Department of Orthopedic Surgery". Brigham and Women's Hospital . 23 July 2015.
  6. "James D. Kang". MedCentral.
  7. M.Ed, Elizabeth Hofheinz, M. P. H. (2023-10-31). "James D. Kang, M.D. Elected ABOS President". Orthopedics This Week. Retrieved 2025-09-22.{{cite web}}: CS1 maint: multiple names: authors list (link)
  8. "James D. Kang, M.D. Elected ABOS President". Orthopedics This Week. 31 October 2023.
  9. "PAST PRESIDENTS". The International Society for the Study of the Lumbar Spine.
  10. Peloso, Marissa (21 December 2021). "Can Degenerative Disc Disease Be Treated Without Invasive Surgery?". Brigham On a Mission.
  11. Rider, Sean M.; Mizuno, Shuichi; Kang, James D. (25 January 2019). "Molecular Mechanisms of Intervertebral Disc Degeneration". Spine Surgery and Related Research. 3 (1): 1–11. doi:10.22603/ssrr.2017-0095. PMC   6690117 . PMID   31435545.
  12. Kang, James D. (31 March 2020). "Commentary on "Gene Therapy Approach for Intervertebral Disc Degeneration: An Update"". Neurospine. 17 (1): 15–16. doi:10.14245/ns.2040092.046. PMC   7136106 . PMID   32252150.
  13. Hofheinz, Elizabeth (18 September 2015). "James D. Kang, M.D.: New Orthopedic Chair at BWH". Orthopedics This Week.
  14. "Hip-Spine Syndrome: It's Complicated (and Often Overlooked) | Mass General Brigham". www.massgeneralbrigham.org.
  15. "Dr. James Kang Named a Top Spine Surgeon". McGowan Institute for Regenerative Medicine . 27 March 2012.
  16. "Dr. James Kang to receive 2016 McEllroy Award | Department of Orthopaedic Surgery | University of Pittsburgh". www.orthonet.pitt.edu.
  17. Silvestre, Jason; Walker, Jasmine J.; Kang, James D.; Ravinsky, Robert A.; Lawrence, James P.; Van Nortwick, Sarah S.; Reitman, Charles A. (2025-08-28). "Sex Disparities in Spine Surgeon Leadership of Clinical Trials for Degenerative Spine Disease Research". Journal of the American Academy of Orthopaedic Surgeons. doi:10.5435/JAAOS-D-24-00222. ISSN   1067-151X. PMID   40907001.
  18. Silvestre, Jason; Hernandez, Jaslyn A.; Ravinsky, Robert A.; Kang, James D.; Wu, Hao Hua; Reitman, Charles A.; Lawrence, James P. (2025). "Shifts in diversity along the spine surgery training pathway: racial, ethnic, and gender representation from medical school to fellowship". The Spine Journal. doi:10.1016/j.spinee.2025.08.332.
  19. Yurube, Takashi; Buchser, William J.; Zhang, Zhongying; Silwal, Prashanta; Lotze, Michael T.; Kang, James D.; Sowa, Gwendolyn A.; Vo, Nam V. (2024). "Rapamycin mitigates inflammation-mediated disc matrix homeostatic imbalance by inhibiting mTORC1 and inducing autophagy through Akt activation". JOR Spine. 7 (1) e1303. doi:10.1002/jsp2.1303. ISSN   2572-1143. PMC   10782056 . PMID   38222800.