AstraZeneca plc (AZ) is a British-Swedish multinational pharmaceutical and biotechnology company with its headquarters at the Cambridge Biomedical Campus in Cambridge,England. It has a portfolio of products for major diseases in areas including oncology,cardiovascular,gastrointestinal,infection,neuroscience,respiratory,and inflammation. It was involved in developing the Oxford–AstraZeneca COVID-19 vaccine.
Frank Edward Young was an American physician who served as Commissioner of Food and Drugs from 1984 to 1989 and later as a deputy assistant secretary in the United States Department of Health and Human Services. In 2013 he joined Braeburn Pharmaceuticals as executive vice president,clinical and regulatory affairs. In 2018,he became the executive vice president of clinical and regulatory affairs at TissueTech Inc.
Esomeprazole,sold under the brand name Nexium [or Neksium] among others,is a medication which reduces stomach acid. It is used to treat gastroesophageal reflux disease,peptic ulcer disease,and Zollinger–Ellison syndrome. Its effectiveness is similar to that of other proton pump inhibitors (PPIs). It is taken by mouth or injection into a vein.
Andrew C. von Eschenbach was the Commissioner of the United States Food and Drug Administration from 2006 to 2009. He became acting Commissioner on September 26,2005,after the resignation of his predecessor Lester Crawford,and was confirmed as Commissioner by the Senate on December 7,2006. He was previously the 12th director of the National Cancer Institute.
Emergent BioSolutions Inc. is an American multinational specialty biopharmaceutical company headquartered in Gaithersburg,Maryland. It develops vaccines and antibody therapeutics for infectious diseases and opioid overdoses,and it provides medical devices for biodefense purposes.
Tremelimumab,sold under the brand name Imjudo,is a fully human monoclonal antibody used for the treatment of hepatocellular carcinoma. Tremelimumab is designed to attach to and block CTLA-4,a protein that controls the activity of T cells,which are part of the immune system.
Sir Menelaos (Mene) Nicolas Pangalos is a British neuroscientist of Greek descent.
Stephen Michael Hahn is an American physician who served as the commissioner of food and drugs from 2019 to 2021. Before becoming commissioner,he was an oncologist serving as chief medical executive of the MD Anderson Cancer Center. In 2021,he became chief medical officer at Flagship Pioneering,the venture capital firm that launched Moderna.
Margaret Ann "Peggy" Hamburg is an American physician and public health administrator,who is serving as the chair of the board of the American Association for the Advancement of Science (AAAS) and co-chair of the InterAcademy Partnership (IAP). She served as the 21st Commissioner of the U.S. Food and Drug Administration from May 2009 to April 2015.
Olaparib,sold under the brand name Lynparza,is a medication for the maintenance treatment of BRCA-mutated advanced ovarian cancer in adults. It is a PARP inhibitor,inhibiting poly ADP ribose polymerase (PARP),an enzyme involved in DNA repair. It acts against cancers in people with hereditary BRCA1 or BRCA2 mutations,which include some ovarian,breast,and prostate cancers.
The Ontario Institute for Cancer Research (OICR) is a not-for-profit organization based in Toronto,Ontario,Canada that focuses on research into the prevention,early detection,diagnosis and treatment of cancer. OICR intends to make Ontario more effective in knowledge transfer and commercialization while maximizing the health and economic benefits of research findings for the people of Ontario. OICR was launched in 2005 by the Government of Ontario,which provides funding through the Ministry of Colleges and Universities. The Institute employs more than 300 people at its research hub at the MaRS Centre in downtown Toronto and funds more than 1,900 scientific staff at hospital-based research institutes and universities around the province. In 2018 it was the highest funder of cancer research in Canada.
The Reagan-Udall Foundation for the Food and Drug Administration is a private nonprofit (501c3) organization,created to support the mission of the U.S. Food and Drug Administration (FDA) to help equip FDA staff with the highest caliber,regulatory science and technology in order to enhance the safety and effectiveness of FDA regulated products. Although it was mandated by Congress in the Food and Drug Administration Amendments Act of 2007 to help support and promote FDA's regulatory science priorities,it is independent of the agency,with its own Board of Directors,staff and research agenda. The Reagan-Udall Foundation creates public–private partnerships to advance research in regulatory science,enhance medical decision making,and promote innovation. It also advances regulatory science through fellowships and other training programs,both for private scientists and for FDA staff.
Brett P. Giroir is an American pediatrician. He was formerly the U.S. assistant secretary for health,a four-star admiral in the U.S. Public Health Service Commissioned Corps and an acting Food and Drug Administration commissioner.
Robert McKinnon Califf is an American cardiologist who currently serves as the 25th Commissioner of the Food and Drug Administration.
The Institute for Clinical and Economic Review (ICER) is a Boston-based independent nonprofit organization that seeks to place a value on medical care by providing comprehensive clinical and cost-effectiveness analyses of treatments,tests,and procedures.
Janet Woodcock is an American physician who served as Principal Deputy Commissioner of Food and Drugs from February 2022 until February 2024,having previously served as Acting Commissioner of the U.S. Food and Drug Administration (FDA). She joined the FDA in 1986,and has held a number of senior leadership positions there,including terms as the Director of Center for Drug Evaluation and Research (CDER) from 1994 to 2004 and 2007 to 2021.
Doris M. Honig Merritt was an American physician and the first woman to serve on a board for the National Library of Medicine. Her contributions included serving as the first women on both the National Library of Medicine and the Assistant Dean of Medical research at Indiana University School of Medicine. Her inspiration to become a doctor came after serving in the Navy during World War II when she had to begin searching for a long-term profession.
Stella Kyriakides is a Cypriot psychologist and politician of the conservative Democratic Rally party who has been serving as European Commissioner for Health and Food Safety since 2019. She was the first Cypriot national and third woman to serve as President of the Parliamentary Assembly of the Council of Europe.
Mikael Dolsten is a Swedish-American physician scientist,and the President of research and development-Medical of the American Pharmaceutical company Pfizer.
Tixagevimab/cilgavimab,sold under the brand name Evusheld,is a combination of two human monoclonal antibodies,tixagevimab (AZD8895) and cilgavimab (AZD1061) targeted against the surface spike protein of SARS-CoV-2 used to prevent COVID-19. It is being developed by British-Swedish multinational pharmaceutical and biotechnology company AstraZeneca. It is co-packaged and given as two separate consecutive intramuscular injections.
