John S. Fossey

Last updated
John S. Fossey
Scientific career
Fields
Institutions University of Birmingham
Henan Normal University
East China University of Science and Technology [1]
Website johnfossey.com

John S. Fossey was a British chemist. He was a professor of synthetic chemistry at the University of Birmingham in the United Kingdom, and a visiting professor at Henan Normal University and guest professor at East China University of Science and Technology, both in China. His research was in molecular recognition and catalysis, and he was a user of boronic acid derivatives. [1] He was a former industry fellow of the Royal Society. [2]

Contents

Education

Fossey received his four-year MChem from Cardiff University in 2000 and was awarded a PhD from Queen Mary University of London in January 2004.

Research and career

Fossey’s research looks at synthetic chemistry to develop new therapies for tuberculosis and diabetes. This work on diabetes involves an alternative drug delivery for type 1 diabetes management. [3] This research is in collaboration with the Chinese Academy of Sciences research institute Guangzhou Institutes of Biomedical Health (GIBH)., [1] to develop new drugs that could help tackle global epidemics. Specifically, Fossey is developing a ‘smart insulin’, a gel that dissolves in the presence of glucose, as an alternative to insulin injection. The idea is that the smart insulin, as a smart drug delivery, can be administered perhaps once a week and will deliver insulin as and only when glucose levels are raised. [4] [5]

He was on the advisory board of two Royal Society of Chemistry journals, Organic Chemistry Frontiers [6] and Catalysis Science & Technology , [7] and the editorial board of the Chemistry Central Journal . [8] He was a co-editor of Boron: Sensing, Synthesis and Supramolecular Self-Assembly. [9]

Recognition

Fossey received a Japan Society for the Promotion of Science postdoctoral fellowship in 2004, and its Bridge Fellowship in 2010; he is chair of the alumni executive committee of the society in the UK and Republic of Ireland. [10] He is also the international student tutor and international representative for the school of chemistry in the University of Birmingham. [11]

He has received funding from the JDRF, CRUK, Leverhulme Trust, the EPSRC, the Royal Society, the Sasakawa Foundation, and the National Natural Science Foundation China. [12] [1] He was a member of a team headed by Tony D. James which received the Daiwa Adrian Prize in 2013 for research into 'chemonostics'. [13] In 2016, he received the Czarnik Emerging Investigator Award for work on catalysis and sensing. [14]

He was awarded the CRUK Pioneer Award in 2018 to support his research in establishing early detection potential from single molecule chemosensors. [15] He is the principal investigator of a JDRF project focused on translating boronic acid-mediated recognition to smart drug delivery for diabetes. [16]

Related Research Articles

<span class="mw-page-title-main">Insulin</span> Peptide hormone

Insulin is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the INS gene. It is considered to be the main anabolic hormone of the body. It regulates the metabolism of carbohydrates, fats and protein by promoting the absorption of glucose from the blood into liver, fat and skeletal muscle cells. In these tissues the absorbed glucose is converted into either glycogen via glycogenesis or fats (triglycerides) via lipogenesis, or, in the case of the liver, into both. Glucose production and secretion by the liver is strongly inhibited by high concentrations of insulin in the blood. Circulating insulin also affects the synthesis of proteins in a wide variety of tissues. It is therefore an anabolic hormone, promoting the conversion of small molecules in the blood into large molecules inside the cells. Low insulin levels in the blood have the opposite effect by promoting widespread catabolism, especially of reserve body fat.

Supramolecular chemistry refers to the branch of chemistry concerning chemical systems composed of a discrete number of molecules. The strength of the forces responsible for spatial organization of the system range from weak intermolecular forces, electrostatic charge, or hydrogen bonding to strong covalent bonding, provided that the electronic coupling strength remains small relative to the energy parameters of the component. While traditional chemistry concentrates on the covalent bond, supramolecular chemistry examines the weaker and reversible non-covalent interactions between molecules. These forces include hydrogen bonding, metal coordination, hydrophobic forces, van der Waals forces, pi–pi interactions and electrostatic effects.

JDRF is a nonprofit 501(c)(3) organization that funds type 1 diabetes (T1D) research, provides a broad array of community and activist services to the T1D population and actively advocates for regulation favorable to medical research and approval of new and improved treatment modalities. It was initially founded as the JDF, the Juvenile Diabetes Foundation. It later changed its name to the Juvenile Diabetes Research Foundation and is now known as JDRF.

<span class="mw-page-title-main">Biguanide</span> Chemical compound

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Arthur Dale Riggs was an American geneticist who worked with Genentech to express the first artificial gene in bacteria. His work was critical to the modern biotechnology industry because it was the first use of molecular techniques in commercial production of drugs and enabled the large-scale manufacturing of protein drugs, including insulin. He was also a major factor in the origin of epigenetics.

<span class="mw-page-title-main">Lisofylline</span> Chemical compound

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Tobin Jay Marks is the Vladimir N. Ipatieff Professor of Catalytic Chemistry, Professor of Material Science and Engineering, Professor of Chemical and Biological Engineering, and Professor of Applied Physics at Northwestern University in Evanston, Illinois. Among the themes of his research are synthetic organo-f-element and early-transition metal organometallic chemistry, polymer chemistry, materials chemistry, homogeneous and heterogeneous catalysis, molecule-based photonic materials, superconductivity, metal-organic chemical vapor deposition, and biological aspects of transition metal chemistry.

Steven Victor Ley is Professor of Organic Chemistry in the Department of Chemistry at the University of Cambridge, and is a Fellow of Trinity College, Cambridge. He was President of the Royal Society of Chemistry (2000–2002) and was made a CBE in January 2002, in the process. In 2011, he was included by The Times in the list of the "100 most important people in British science".

Dame Frances Mary Ashcroft is a British ion channel physiologist. She is Royal Society GlaxoSmithKline Research Professor at the University Laboratory of Physiology at the University of Oxford. She is a fellow of Trinity College, Oxford, and is a director of the Oxford Centre for Gene Function. Her research group has an international reputation for work on insulin secretion, type II diabetes and neonatal diabetes. Her work with Andrew Hattersley has helped enable children born with diabetes to switch from insulin injections to tablet therapy.

Howard Colquhoun is Emeritus Professor of Materials Chemistry in the University of Reading. He was born (1951) in County Durham and was educated at Washington Grammar School and at the University of Cambridge, before moving to the University of London as a research student in chemistry. At Cambridge he was a member of the University athletics team and was awarded a half-blue for throwing the discus. He carried out postdoctoral work at the University of Warwick, and was then a researcher at the ICI Corporate Laboratory in Cheshire where he and Fraser Stoddart developed a useful collaboration. In 1994 he moved to Manchester University as a Royal Society Industry Fellow. From 1997 he was Professor of Inorganic Chemistry at the University of Salford. In 2000 he was appointed to the Chair of Materials Chemistry in the University of Reading where, from 2002 to 2006, he served as Head of the School of Chemistry. In 2007 he was elected a Visiting Fellow of Clare Hall, University of Cambridge. His research has contributed to the fields of silicon chemistry, boron chemistry, transition-metal chemistry, dinitrogen chemistry, supramolecular chemistry and polymer chemistry, resulting in some 250 publications. Awards for his work include the RSC Medal and Prize for Materials Chemistry (2005), the degree of Doctor of Science (ScD) of the University of Cambridge (2008), the Wilsmore Fellowship of the University of Melbourne (2007), the Macro Group UK Medal for contributions to polymer science (2012), and the "Leverhulme" Senior Research Fellowship of the Royal Society (2006). He retired, becoming Professor Emeritus, in December 2018.

John Andrew Todd FMedSci FRS is Professor of Precision Medicine at the University of Oxford, director of the Wellcome Center for Human Genetics and the JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, in addition to Jeffrey Cheah Fellow in Medicine at Brasenose College. He works in collaboration with David Clayton and Linda Wicker to examine the molecular basis of type 1 diabetes.

Bruce Bode, MD, FACE is a diabetes specialist with the Atlanta Diabetes Associates in Atlanta, GA and is a clinical associate professor at Emory University in the Department of Medicine. He has served on the board of directors of the Atlanta chapters of the Juvenile Diabetes Research Foundation (JDRF), the American Diabetes Association (ADA), and various Georgia-based diabetes camps. Bode is a member of the board of directors of Glytec and an active member of the JDRF research team validating the efficacy and safety of real-time continuous glucose monitoring (CGMS), and is a former president of the ADA Georgia Affiliate and editor of the ADA's 2004 edition of Medical Management of Type 1 Diabetes.

<span class="mw-page-title-main">Paul Attfield</span>

John Paul Attfield is a Professor of Materials science in the School of Chemistry at the University of Edinburgh and Director of the Centre for Science at Extreme Conditions (CSEC).

<span class="mw-page-title-main">Ben Feringa</span> Dutch Nobel laureate in chemistry

Bernard Lucas Feringa is a Dutch synthetic organic chemist, specializing in molecular nanotechnology and homogeneous catalysis. He is the Jacobus van 't Hoff Distinguished Professor of Molecular Sciences, at the Stratingh Institute for Chemistry, University of Groningen, Netherlands, and an Academy Professor of the Royal Netherlands Academy of Arts and Sciences. He was awarded the 2016 Nobel Prize in Chemistry, together with Sir J. Fraser Stoddart and Jean-Pierre Sauvage, "for the design and synthesis of molecular machines".

Julie Macpherson is a professor of chemistry at the University of Warwick. In 2017 she was awarded the Royal Society Innovation award for her research into boron doped diamond electrochemical sensors.

Rachel O'Reilly is a British chemist and Professor at the University of Birmingham. She works at the interface of biology and materials, creating polymers that can mimic natural nanomaterials such as viruses and cells. She is a Fellow of the Royal Society of Chemistry and of the Royal Society.

Feng "Franklin" Tao is a chemical engineer who has been a Miller Associate Professor at the University of Kansas since 2014. His research areas of specialization are heterogeneous catalysis, energy chemistry, nanoscience and surface science. He has published over 180 papers in international journals. He received the National Science Foundation Career Award by the Chemical Catalysis Program for research and became a fellow of the Royal Society of Chemistry in 2013.

<span class="mw-page-title-main">Anthony Czarnik</span> American biochemist and inventor

Anthony W. Czarnik is an American chemist and inventor. He is best known for pioneering studies in the field of fluorescent chemosensors and co-founding Illumina, Inc., a biotechnology company in San Diego. Czarnik was also the founding editor of ACS Combinatorial Science. He currently serves as an adjunct visiting professor at the University of Nevada, Reno.

William V. Tamborlane has been Professor and Chief of Pediatric Endocrinology at Yale School of Medicine since 1986.

References

  1. 1 2 3 4 5 "Professor John Fossey". birmingham.ac.uk.
  2. "Royal Society". royalsociety.org.
  3. "University of Birmingham and GIBH in China collaborate to develop new drugs for global epidemics". epmmagazine.com. 2018.
  4. "'Smart' insulin could drastically reduce injections". bbc.co.uk. 2016.
  5. Fossey, John S.; Male, Louise; Zhai, Wenlei (2017). "Glucose selective bis-boronic acid click-fluor". ChemComm . 53 (14): 2218–2221. doi: 10.1039/C6CC08534B . PMID   27904892.
  6. "Organic Chemistry Frontiers". rsc.org.
  7. "Catalysis Science & Technology". rsc.org.
  8. "Chemistry Central Journal". rsc.org.
  9. M. Li, J. S. Fossey and T. D. James, eds., Boron: Sensing, synthesis and supramolecular self-assembly , The Royal Society of Chemistry (Cambridge, 2015)
  10. "Alumni". jsps.org.
  11. "JSF Research Group".
  12. "John S. Fossey". orcid.org.
  13. "2013 Daiwa Adrian Prize Winners". dajf.org.uk.
  14. "2016 Czarnik Emerging Investigator Award". 12 July 2016.
  15. "Thinking differently to drive innovation in cancer research". 6 April 2018.
  16. "Glucose-Responsive Insulin Therapy (GRIT)". jdrf.org.uk.