Senden was born in Brisbane, Queensland and turned pro in 1992. Senden has played all over the world. He is a regular competitor on the PGA Tour of Australasia and has spent time playing in Asia. In Europe he won twice on the second tier Challenge Tour in 1998 and was a member of the main European Tour from 1999 to 2001.
In 2002, Senden joined the PGA Tour in the United States, after coming through the qualifying school in 2001. During his first year on tour he successfully kept his playing status with eight top-25 finishes in 30 events. He claimed his first PGA Tour title on 16 July 2006 at the John Deere Classic, a one-shot victory over American J. P. Hayes. Later in 2006 he won his national open for the first time. In 2007, he was the leading Australian at the PGA Championship which was won by Tiger Woods and reached the top 50 of the Official World Golf Ranking.[2]
In March 2014, Senden won his second PGA Tour title (and first in eight years) at the Valspar Championship by one stroke over Kevin Na.[3] In the final round, he came from two strokes back to shoot a one-under 70 to seal victory. The win qualified Senden for the 2014 Masters Tournament[3] where he finished T-8.
Senden's son was diagnosed with a brain tumor in April 2017. Senden played the next two seasons using a Major Medical Extension under the family crisis provision, but he was unable to meet the terms and was demoted to the Past Champions Category. He played the 2019–20 season using an exemption for those who made 300 PGA Tour cuts.
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