| Year | Title | Actor | Writer | Executive Producer | Role | Notes |
|---|
| 2003–08 | Mad TV | Yes | Yes | No | Various | 94 episodes |
| 2008 | Chocolate News | Yes | No | No | Kelvin Melvin | 7 episodes |
| 2009 | Reno 911! | Yes | No | No | Three-Card Monte Guy | Episode: "Extradition to Thailand" |
| 2009–10 | SuperNews! | Yes | No | No | Various voices | 15 episodes |
| 2010–15 | Childrens Hospital | Yes | No | No | Dr. Brian | 10 episodes |
| 2011 | Love Bites | Yes | No | No | Eli | Episode: "Too Much Information" |
| 2012–15 | Key & Peele | Yes | Yes | Yes | Himself, Various | 54 episodes; also co-creator |
| 2013 | The Mindy Project | Yes | No | No | Nick | Episode: "Mindy's Minute" |
| Workaholics | Yes | No | No | Mark | Episode: "The Worst Generation" |
| Comedy Bang! Bang! | Yes | No | No | Tan Fu | Episode: "Andy Samberg Wears a Plaid Shirt & Glasses" |
| Modern Family | Yes | No | No | Derrick | Episode: "A Fair to Remember" |
| 2013 | Axe Cop | Yes | No | No | Super Axe (voice) | Episode: "Super Axe" |
| 2013–14 | Kroll Show | Yes | No | No | Ref Rondy, Various | 2 episodes |
| 2014 | Fargo | Yes | No | No | Agent Webb Pepper | 4 episodes |
| Drunk History | Yes | No | No | Percy Julian | Episode: "Montgomery, AL" |
| Robot Chicken | Yes | No | No | Blade, various voices | 2 episodes |
| Rick and Morty | Yes | No | No | 4th-Dimensional Being (voice) | Episode: "A Rickle in Time" |
| 2014–16 | Bob's Burgers | Yes | No | No | Various voices | 8 episodes |
| 2015 | Life in Pieces | Yes | No | No | Chad | 3 episodes |
Wet Hot American Summer:
First Day of Camp | Yes | No | No | Alan | 3 episodes |
| TripTank | Yes | No | No | Various voices | 2 episodes |
| 2015–18 | SuperMansion | Yes | No | No | Bugula (voice) | 2 episodes |
| 2016 | The Muppets | Yes | No | No | Himself | Episode: "Swine Song" |
| American Dad! | Yes | No | No | Street Thug (voice) | Episode: "Criss-Cross Applesauce: The Ballad of Billy Jesusworth" |
| 2017–25 | Big Mouth | Yes | No | No | The Ghost of Duke Ellington
/ various voices | 71 episodes |
| 2018 | The Shivering Truth | Yes | No | No | Prison Guard | Episode: "Ogled Inklings" |
| 2018–21 | The Last O.G. | No | Yes | Yes | — | 40 episodes; also co-creator |
| 2019 | Weird City | No | Yes | Yes | — | 6 episodes; also co-creator |
| Lorena | No | No | Yes | — | 4 episodes |
| 2019–20 | The Twilight Zone | Yes | Yes | Yes | Host / Narrator | 20 episodes |
| 2020–23 | Hunters | No | No | Yes | — | 18 episodes |
| 2020 | Lovecraft Country | No | No | Yes | — | 10 episodes |
| 2024 | Scare Tactics | Yes | No | Yes | Host | Unknown |
