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Jory Bell is an American executive who is a general partner at Playground Global, a venture capital firm based in Palo Alto, California. [1] [2] [3] He joined the firm in 2015 as vice president and has been involved in investments in deep tech areas such as advanced manufacturing, aerospace, genomics, and synthetic/computational biology. [1] [4]
Bell grew up in Rochester, New York, and attended the Massachusetts Institute of Technology, where he earned undergraduate degrees in architecture, literature, and earth, atmospheric, and planetary sciences. [3] [5] [4] He worked as a researcher with the MIT/Woods Hole Oceanographic Institute climate change program, designing, building, and deploying autonomous deep-sea robotics. [3] [4]
Bell spent six years at Apple as a product designer before founding OQO in 2000, a company credited by the Guinness World Records as having created the world’s smallest Windows PC. [6] [7] [8] He then joined Playground Global, where he has played a part in investments in Nervana Systems (acquired by Intel), Velo3D (which went public in October 2021), and Relativity Space. [3] [4] He leads Playground’s engineered biology investing practice with investments in companies including Ultima Genomics, Strand Therapeutics and Manifold Bio. [3] [4] [9]
Bell serves on the boards of Amber Bio, Atomic AI, Manifold Bio, Relativity Space, Strand Therapeutics, and Ultima Genomics. [10] [11] [12] [13] [1] [4]
In genetics, complementary DNA (cDNA) is DNA that was reverse transcribed from an RNA. cDNA exists in both single-stranded and double-stranded forms and in both natural and engineered forms.
Gene silencing is the regulation of gene expression in a cell to prevent the expression of a certain gene. Gene silencing can occur during either transcription or translation and is often used in research. In particular, methods used to silence genes are being increasingly used to produce therapeutics to combat cancer and other diseases, such as infectious diseases and neurodegenerative disorders.
Molecular genetics is a branch of biology that addresses how differences in the structures or expression of DNA molecules manifests as variation among organisms. Molecular genetics often applies an "investigative approach" to determine the structure and/or function of genes in an organism's genome using genetic screens.
F. Hoffmann-La Roche AG, commonly known as Roche, is a Swiss multinational holding healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has shares listed on the SIX Swiss Exchange. The company headquarters are located in Basel. Roche is the fifth-largest pharmaceutical company in the world by revenue and the leading provider of cancer treatments globally. In 2023, the company’s seat in Forbes Global 2000 was 76.
Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded non-coding RNA molecules, typically 20–24 base pairs in length, similar to microRNA (miRNA), and operating within the RNA interference (RNAi) pathway. It interferes with the expression of specific genes with complementary nucleotide sequences by degrading messenger RNA (mRNA) after transcription, preventing translation. It was discovered in 1998 by Andrew Fire at the Carnegie Institution for Science in Washington, D.C. and Craig Mello at the University of Massachusetts in Worcester.
Sarepta Therapeutics, Inc. is a medical research and drug development company with corporate offices and research facilities in Cambridge, Massachusetts, United States. Incorporated in 1980 as AntiVirals, shortly before going public the company changed its name from AntiVirals to AVI BioPharma soon with stock symbol AVII and in July 2012 changed name from AVI BioPharma to Sarepta Therapeutics and SRPT respectively. As of 2023, the company has four approved drugs.
George McDonald Church is an American geneticist, molecular engineer, chemist, serial entrepreneur, and pioneer in personal genomics and synthetic biology. He is the Robert Winthrop Professor of Genetics at Harvard Medical School, Professor of Health Sciences and Technology at Harvard University and Massachusetts Institute of Technology, and a founding member of the Wyss Institute for Biologically Inspired Engineering at Harvard University.
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and non-coding genes. During gene expression, DNA is first copied into RNA. RNA can be directly functional or be the intermediate template for the synthesis of a protein.
Yvonne Choquet-Bruhat is a French mathematician and physicist. She has made seminal contributions to the study of general relativity, by showing that the Einstein field equations can be put into the form of an initial value problem which is well-posed. In 2015, her breakthrough paper was listed by the journal Classical and Quantum Gravity as one of thirteen 'milestone' results in the study of general relativity, across the hundred years in which it had been studied.
Jennifer Anne Doudna is an American biochemist who has pioneered work in CRISPR gene editing, and made other fundamental contributions in biochemistry and genetics. She received the 2020 Nobel Prize in Chemistry, with Emmanuelle Charpentier, "for the development of a method for genome editing." She is the Li Ka Shing Chancellor's Chair Professor in the department of chemistry and the department of molecular and cell biology at the University of California, Berkeley. She has been an investigator with the Howard Hughes Medical Institute since 1997.
Jonathan "Joe" Betts-LaCroix is an American scientist and entrepreneur known for his discoveries in biophysics and for creating the world's smallest personal computer. He is working to optimize medical research priorities in the U.S.
Moderna, Inc. is an American pharmaceutical and biotechnology company based in Cambridge, Massachusetts, that focuses on RNA therapeutics, primarily mRNA vaccines. These vaccines use a copy of a molecule called messenger RNA (mRNA) to carry instructions for proteins to produce an immune response. The company's name is derived from the terms "modified", "RNA", and "modern".
Standard BioTools Inc., previously known as Fluidigm Corp., offers analytical mass cytometry systems for flow cytometry and tissue imaging, along with associated assays and reagents, as well as an automated genomic analysis instrument and a variety of microfluidic arrays, or integrated fluidic circuits (IFCs), and consumables with fully kitted reagents. Custom assays and services are available with all systems and applications.
Playground Global, LLC is a venture capital firm established in 2015 and located in Palo Alto, CA, which focuses on early-stage deep tech investments.
Positive-strand RNA viruses are a group of related viruses that have positive-sense, single-stranded genomes made of ribonucleic acid. The positive-sense genome can act as messenger RNA (mRNA) and can be directly translated into viral proteins by the host cell's ribosomes. Positive-strand RNA viruses encode an RNA-dependent RNA polymerase (RdRp) which is used during replication of the genome to synthesize a negative-sense antigenome that is then used as a template to create a new positive-sense viral genome.
Manifold Garden is a puzzle video game developed by American artist William Chyr. It was released on Windows, macOS, and iOS on October 18, 2019. The player must navigate an abstract series of structures that appear to repeat into infinity, while solving a progression of puzzles. Ports for PlayStation 4, Nintendo Switch and Xbox One were released on August 18, 2020. An upgraded version of the game was released for Xbox Series X and Series S as a launch title on November 10, 2020, and an upgraded PlayStation 5 version released on May 20, 2021.
An mRNAvaccine is a type of vaccine that uses a copy of a molecule called messenger RNA (mRNA) to produce an immune response. The vaccine delivers molecules of antigen-encoding mRNA into cells, which use the designed mRNA as a blueprint to build foreign protein that would normally be produced by a pathogen or by a cancer cell. These protein molecules stimulate an adaptive immune response that teaches the body to identify and destroy the corresponding pathogen or cancer cells. The mRNA is delivered by a co-formulation of the RNA encapsulated in lipid nanoparticles that protect the RNA strands and help their absorption into the cells.
Ultragenyx Pharmaceutical Inc. is an American biopharmaceutical company involved in the research and development of novel products for treatment of rare and ultra-rare genetic diseases for which there are typically no approved treatments and high unmet medical need. The company works with multiple drug modalities including biologics, small molecule, gene therapies, and ASO and mRNAs in the disease categories of bone, endocrine, metabolic, muscle and CNS diseases.
John Maraganore is an American scientist, entrepreneur, and life sciences industry leader.
Pieter Rutter Cullis is a Canadian physicist and biochemist known for his contributions to the field of lipid nanoparticles (LNP). Cullis and co-workers have been responsible for fundamental advances in the development of nanomedicines employing lipid nanoparticle (LNP) technology for cancer therapies, gene therapies and vaccines. This work has contributed to five drugs that have received clinical approval by the US Food and Drug Agency (FDA), the European Medicines Agency, and Health Canada.
