Inflammation is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators. The function of inflammation is to eliminate the initial cause of cell injury, clear out necrotic cells and tissues damaged from the original insult and the inflammatory process, and initiate tissue repair.
Phlegm is mucus produced by the respiratory system, excluding that produced by the nasal passages. It often refers to respiratory mucus expelled by coughing, otherwise known as sputum. Phlegm, and mucus as a whole, is in essence a water-based gel consisting of glycoproteins, immunoglobulins, lipids and other substances. Its composition varies depending on climate, genetics, and state of the immune system. Its color can vary from transparent to pale or dark yellow and green, from light to dark brown, and even to dark grey depending on the constituents. The body naturally produces about 1 quart of phlegm every day to capture and clear substances in the air and bacteria from the nose and throat.
C-reactive protein (CRP) is an annular (ring-shaped) pentameric protein found in blood plasma, whose circulating concentrations rise in response to inflammation. It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells. Its physiological role is to bind to lysophosphatidylcholine expressed on the surface of dead or dying cells in order to activate the complement system via C1q.
An academic journal or scholarly journal is a periodical publication in which scholarship relating to a particular academic discipline is published. Academic journals serve as permanent and transparent forums for the presentation, scrutiny, and discussion of research. They nearly universally require peer review or other scrutiny from contemporaries competent and established in their respective fields. Content typically takes the form of articles presenting original research, review articles, or book reviews. The purpose of an academic journal, according to Henry Oldenburg, is to give researchers a venue to "impart their knowledge to one another, and contribute what they can to the Grand design of improving natural knowledge, and perfecting all Philosophical Arts, and Sciences."
Enteritis is inflammation of the small intestine. It is most commonly caused by food or drink contaminated with pathogenic microbes, such as serratia, but may have other causes such as NSAIDs, radiation therapy as well as autoimmune conditions like Crohn's disease and celiac disease. Symptoms include abdominal pain, cramping, diarrhea, dehydration, and fever. Related diseases of the gastrointestinal system include inflammation of the stomach and large intestine.
The BMJ is a weekly peer-reviewed medical trade journal, published by the trade union the British Medical Association (BMA). The BMJ has editorial freedom from the BMA. It is one of the world's oldest general medical journals. Originally called the British Medical Journal, the title was officially shortened to BMJ in 1988, and then changed to The BMJ in 2014. The journal is published by BMJ Publishing Group Ltd, a subsidiary of the British Medical Association (BMA). The editor-in-chief of The BMJ is Kamran Abbasi, who was appointed in January 2022.
Vasculitis is a group of disorders that destroy blood vessels by inflammation. Both arteries and veins are affected. Lymphangitis is sometimes considered a type of vasculitis. Vasculitis is primarily caused by leukocyte migration and resultant damage. Although both occur in vasculitis, inflammation of veins (phlebitis) or arteries (arteritis) on their own are separate entities.
Leukotrienes are a family of eicosanoid inflammatory mediators produced in leukocytes by the oxidation of arachidonic acid (AA) and the essential fatty acid eicosapentaenoic acid (EPA) by the enzyme arachidonate 5-lipoxygenase.
WEHI, previously known as the Walter and Eliza Hall Institute of Medical Research, and as the Walter and Eliza Hall Institute, is Australia's oldest medical research institute. Sir Frank Macfarlane Burnet, who won the Nobel Prize in 1960 for his work in immunology, was director from 1944 to 1965. Burnet developed the ideas of clonal selection and acquired immune tolerance. Later, Professor Donald Metcalf discovered and characterised colony-stimulating factors. As of 2015, the institute hosted more than 750 researchers who work to understand, prevent and treat diseases including blood, breast and ovarian cancers; inflammatory diseases (autoimmunity) such as rheumatoid arthritis, type 1 diabetes and coeliac disease; and infectious diseases such as malaria, HIV and hepatitis B and C.
Carprofen is a non-steroidal anti-inflammatory drug (NSAID) of the carbazole and propionic acid class that was previously for use in humans and animals, but is now only available to veterinarians for prescribing as a supportive treatment for various conditions in only animals. Carprofen reduces inflammation by inhibition of COX-1 and COX-2; its specificity for COX-2 varies from species to species. Marketed under many brand names worldwide, carprofen provides day-to-day treatment for pain and inflammation from various kinds of joint pain, as well as post-operative pain.
Anthony (Tony) Segal MD PhD FRS FMedSci is a British physician/scientist.
Journal of Experimental Medicine is a monthly peer-reviewed medical journal published by Rockefeller University Press that publishes research papers and commentaries on the physiological, pathological, and molecular mechanisms that encompass the host response to disease. The journal prioritizes studies on intact organisms and has made a commitment to publishing studies on human subjects. Topics covered include immunology, inflammation, infectious disease, hematopoiesis, cancer, stem cells and vascular biology. The journal has no single editor-in-chief, but thirteen academic editors.
Infection and Immunity is a peer-reviewed medical journal published by the American Society for Microbiology. It focuses on interactions between bacterial, fungal, or parasitic pathogens and their hosts. Areas covered include molecular pathogenesis, cellular microbiology, bacterial infection, host responses and inflammation, fungal and parasitic infections, microbial immunity and vaccines, and molecular genomics. The journal publishes primary research articles, editorials, commentaries, minireviews, and a spotlight report highlighting articles of particular interest selected by the editors. Articles are freely accessible after 6 months. Through its "Global Outreach Program," free online access is available to qualified microbiologists in eligible developing countries.
Ralph Snyderman is Chancellor Emeritus at Duke University, James B. Duke Professor of Medicine, and Executive Director of the Duke Center for Personalized Health Care. He served as chancellor for health affairs and dean of the School of Medicine from 1989 to July 2004. Under his leadership, Duke University created the Duke University Health System (DUHS) to develop and operate a comprehensive health delivery system, and he was its founding President and Chief Executive Officer. DUHS, with its practice networks, ambulatory care centers, home health services, community hospitals, university hospital, and satellite collaborations demonstrated the power of academic medicine to deliver the best of care to broad communities. Snyderman helped lead the creation of the largest academic clinical research organization worldwide. During his tenure, Duke University Hospital was ranked 6th overall in the nation and its medical school ranked 4th. Snyderman is a leader in the conception and development of personalized health care, an evolving model of national health care delivery. He has articulated the need to move the current focus of health care from the treatment of disease-events to personalized, predictive, preventive, and participatory care that is focused on the patient. As Senior Vice-President at Genentech, he led the development of powerful new molecular biology therapeutics. Ralph Snyderman was the recipient of the 2012 David E. Rogers Award from the Association of American Medical Colleges which recognized him as "The Father of Personalized Medicine." He is a member of the Association of American Medical Colleges, Association of American Physicians, American Academy of Arts & Sciences, and the National Academy of Medicine.
Kevin J. Tracey, a neurosurgeon and inventor, is the president and CEO of the Feinstein Institute for Medical Research, professor of neurosurgery and molecular medicine at the Zucker School of Medicine, and president of the Elmezzi Graduate School of Molecular Medicine in Manhasset, New York. The Public Library of Science Magazine, PLOS Biology, recognized Tracey in 2019 as one of the most cited researchers in the world.
Palmitoylethanolamide (PEA) is an endogenous fatty acid amide, and lipid modulator PEA has been studied in in vitro and in vivo systems using exogenously added or dosed compound; there is evidence that it binds to a nuclear receptor, through which it exerts a variety of biological effects, some related to chronic inflammation and pain.
Inflammation Research is a monthly peer-reviewed medical journal covering immunology. It was established in 1969 as Agents and Actions, obtaining its current name in 1995. It is the official journal of the European Histamine Research Society and the International Association of Inflammation Societies. The editor-in-chief is John A. Di Battista.
Anurag Agrawal is an Indian pulmonologist, medical researcher, Dean of the Trivedi School of Biosciences at Ashoka University, and the former director of the Institute of Genomics and Integrative Biology, a CSIR institution. Known for his studies on lung diseases, Agrawal has been a senior fellow of the DBT-Wellcome Trust. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards for his contributions to Medical Sciences in 2014. He is also a recipient of the National Bioscience Award for Career Development of the Department of Biotechnology which he received in 2015 and the 2020 Sun Pharma Science Foundation award in Medical Sciences.
