Katherine Kedzierska

Professor Katherine Kedzierska FAHMS
Katherine Kedzierska in 2016 at the Doherty Institute
Alma mater	Monash University (PhD)
Known for	Immunity to viral infections
Awards	2023 Eureka Prize [1] 2018 Woodward Medal [2] 2016 Selwyn Smith Prize [3] 2016 Jacques Miller Medal [4]
Scientific career
Fields	Immunology
Institutions	University of Melbourne Peter Doherty Institute for Infection and Immunity [5]

Katherine (Katarzyna) Kedzierska FAHMS ^[6] is a Polish born internationally recognised Australian immunologist, Professor of Immunology and Deputy Head of Department of Microbiology and Immunology at the University of Melbourne. ^{[7] [8]} Kedzierska is a Laboratory Head at the Peter Doherty Institute for Infection and Immunity (Melbourne, Australia) ^[7] and also holds the positions of Honorary Professor at Hong Kong University (Hong Kong) ^[9] and Adjunct Professor at Hokkaido University (Sapporo, Japan). ^[10]

Early life and education

Kedzierska completed her undergraduate Bachelor of Science degree in 1994 and Bachelor of Science (Hons) in 1995 at Monash University. She received her PhD from Monash University in 2002, studying the mechanisms underlying defective phagocytosis by human monocytes and macrophages following HIV-infection ^[11] under the supervision of Professor Suzanne Crowe at the Burnet Institute. ^[8] This research earned her a 2001 Premier's Commendation for Medical Research ^[7] and the 2002 Monash University Mollie Holman Doctoral Medal. ^[7] Kedzierska undertook postdoctoral training with Nobel Laureate Professor Peter Doherty at the University of Melbourne defining features that underpin long-lasting protective immunity to influenza viruses. ^[8]

Career, research and accomplishments

In 2007 Kedzierska established her Laboratory in the Department of Microbiology and Immunology, University of Melbourne. She was appointed Associate Professor in 2012 and full Professor in 2015. Since 2020 Kedzierska has also been Deputy Head of the Department of Microbiology and Immunology at the University of Melbourne. ^[7] Kedzierska is recognised for her significant contributions to the field of immunity to pandemic, seasonal and newly emerged respiratory viruses, including influenza viruses and SARS-CoV-2. ^{[12] [13] [14] [15] [16]} Her work (see Selected Publications) has described immune networks underpinning the severity of viral disease and recovery from viral infections in the young, the elderly and high risk populations such as pregnant women and Australian First Nations people. She was at the forefront of SARS-CoV-2 research, leading a research group that was the first in the world to publish on immunity to SARS-CoV-2 in one of Australia's first COVID-19 patients. ^{[17] [13] [18]} Her research was recognised by the 2023 Eureka Prize for Infectious Disease Research, ^[12] with Kedzierska being listed as a Highly Cited Researcher annually since 2023. ^{[19] [20]}

Scientific Outreach

Kedzierska serves on the Editorial Boards of PLoS Biology, ^[21] Vaccine, ^[22] Immunology & Cell Biology ^[23] and Clinical & Translational Immunology. ^[24]

Awards, honours and recognition

• 2023 - Australian Museum Eureka Prize for Infectious Diseases ^[12]
• 2020 - 100 Most Influential Women in 2020, Forbes Women (Poland) ^{[25] [26]}
• 2019 - University of Melbourne Dame Kate Campbell Fellow ^[27]
• 2019 - Fellow of the Australian Academy of Health and Medical Sciences ^[6]
• 2018 - Woodward Medal in Science and Technology ^[28]
• 2016 - The Selwyn Smith Medical Research Prize ^[15]
• 2016 - Australian Academy of Science Jacques Miller Medal for Experimental Biomedicine ^{[29] [16]}
• 2011 - Scopus Young Researcher of the Year Award for Medicine and Medical Sciences ^[7]
• 2011 - National Health and Medical Research Council Excellence Award ^[8]
• 2001 - Premier's Commendation for Medical Research ^[7]

Selected Publications

• Jia, X; Crawford, JC; Gebregzabher, D; Monson, EA; Mettelman, RC; Wan, Y; Ren, Y; Chou, J; Novak, T; McQuilten, HA; Clarke, M; Bachem, A; Foo, IJ; Fritzlar, S; Carrera Montoya, J; Trenerry, AM; Nie, S; Leeming, MG; Nguyen, THO; Kedzierski, L; Littler, DR; Kueh, A; Cardamone, T; Wong, CY; Hensen, L; Cabug, A; Laguna, JG; Agrawal, M; Flerlage, T; Boyd, DF; Van de Velde, LA; Habel, JR; Loh, L; Koay, HF; van de Sandt, CE; Konstantinov, IE; Berzins, SP; Flanagan, KL; Wakim, LM; Herold, MJ; Green, AM; Smallwood, HS; Rossjohn, J; Thwaites, RS; Chiu, C; Scott, NE; Mackenzie, JM; Bedoui, S; Reading, PC; Londrigan, SL; Helbig, KJ; Randolph, AG; Thomas, PG; Xu, J; Wang, Z; Chua, BY; Kedzierska, K (22 August 2024). "High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases". Cell. 187 (17): 4586–4604.e20. doi:10.1016/j.cell.2024.07.026. ISSN   1097-4172. PMID   39137778.
• Loh, L; Saunders, PM; Faoro, C; Font-Porterias, N; Nemat-Gorgani, N; Harrison, GF; Sadeeq, S; Hensen, L; Wong, SC; Widjaja, J; Clemens, EB; Zhu, S; Kichula, KM; Tao, S; Zhu, F; Montero-Martin, G; Fernandez-Vina, M; Guethlein, LA; Vivian, JP; Davies, J; Mentzer, AJ; Oppenheimer, SJ; Pomat, W; Ioannidis, AG; Barberena-Jonas, C; Oceanian Genome Variation Project, Consortium; Moreno-Estrada, A; Miller, A; Parham, P; Rossjohn, J; Tong, SYC; Kedzierska, Katherine; Brooks, AG; Norman, PJ (27 November 2024). "An archaic HLA class I receptor allele diversifies natural killer cell-driven immunity in First Nations peoples of Oceania". Cell. 187 (24): 7008–7024.e19. doi:10.1016/j.cell.2024.10.005. ISSN   1097-4172. PMC  11606752. PMID   39476840.
• Thevarajan, Irani; Nguyen, Thi H. O.; Koutsakos, Marios; Druce, Julian; Caly, Leon; van de Sandt, Carolien E.; Jia, Xiaoxiao; Nicholson, Suellen; Catton, Mike; Cowie, Benjamin; Tong, Steven Y. C.; Lewin, Sharon R.; Kedzierska, Katherine (April 2020). "Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19". Nature Medicine. 26 (4): 453–455. doi: 10.1038/s41591-020-0819-2 . ISSN   1546-170X. PMC   7095036 . PMID   32284614.
• Koutsakos, Marios; Illing, Patricia T.; Nguyen, Thi H. O.; Mifsud, Nicole A.; Crawford, Jeremy Chase; Rizzetto, Simone; Eltahla, Auda A.; Clemens, E. Bridie; Sant, Sneha; Chua, Brendon Y.; Wong, Chinn Yi; Allen, E. Kaitlynn; Teng, Don; Dash, Pradyot; Boyd, David F.; Grzelak, Ludivine; Zeng, Weiguang; Hurt, Aeron C.; Barr, Ian; Rockman, Steve; Jackson, David C.; Kotsimbos, Tom C.; Cheng, Allen C.; Richards, Michael; Westall, Glen P.; Loudovaris, Thomas; Mannering, Stuart I.; Elliott, Michael; Tangye, Stuart G.; Wakim, Linda M.; Rossjohn, Jamie; Vijaykrishna, Dhanasekaran; Luciani, Fabio; Thomas, Paul G.; Gras, Stephanie; Purcell, Anthony W.; Kedzierska, Katherine (May 2019). "Human CD8+ T cell cross-reactivity across influenza A, B and C viruses". Nature Immunology. 20 (5): 613–625. doi:10.1038/s41590-019-0320-6. ISSN   1529-2916. PMID   30778243.
• Zhang, W; Kedzierski, L; Chua, BY; Mayo, M; Lonzi, C; Rigas, V; Middleton, BF; McQuilten, HA; Rowntree, LC; Allen, LF; Purcell, RA; Tan, HX; Petersen, J; Chaurasia, P; Mordant, F; Pogorelyy, MV; Minervina, AA; Crawford, JC; Perkins, GB; Zhang, E; Gras, S; Clemens, EB; Juno, JA; Audsley, J; Khoury, DS; Holmes, NE; Thevarajan, I; Subbarao, K; Krammer, F; Cheng, AC; Davenport, MP; Grubor-Bauk, B; Coates, PT; Christensen, B; Thomas, PG; Wheatley, AK; Kent, SJ; Rossjohn, J; Chung, AW; Boffa, J; Miller, A; Lynar, S; Nelson, J; Nguyen, THO; Davies, J; Kedzierska, Katherine (June 2023). "Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities". Nature Immunology. 24 (6): 966–978. doi: 10.1038/s41590-023-01508-y . ISSN   1529-2916. PMC   10232372 . PMID   37248417.
• van de Sandt, Carolien E.; Nguyen, Thi H. O.; Gherardin, Nicholas A.; Crawford, Jeremy Chase; Samir, Jerome; Minervina, Anastasia A.; Pogorelyy, Mikhail V.; Rizzetto, Simone; Szeto, Christopher; Kaur, Jasveen; Ranson, Nicole; Sonda, Sabrina; Harper, Alice; Redmond, Samuel J.; McQuilten, Hayley A.; Menon, Tejas; Sant, Sneha; Jia, Xiaoxiao; Pedrina, Kate; Karapanagiotidis, Theo; Cain, Natalie; Nicholson, Suellen; Chen, Zhenjun; Lim, Ratana; Clemens, E. Bridie; Eltahla, Auda; La Gruta, Nicole L.; Crowe, Jane; Lappas, Martha; Rossjohn, Jamie; Godfrey, Dale I.; Thomas, Paul G.; Gras, Stephanie; Flanagan, Katie L.; Luciani, Fabio; Kedzierska, Katherine (November 2023). "Newborn and child-like molecular signatures in older adults stem from TCR shifts across human lifespan". Nature Immunology. 24 (11): 1890–1907. doi: 10.1038/s41590-023-01633-8 . ISSN   1529-2916. PMC   10602853 . PMID   37749325.
• Nguyen, Thi H. O.; Rowntree, Louise C.; Petersen, Jan; Chua, Brendon Y.; Hensen, Luca; Kedzierski, Lukasz; van de Sandt, Carolien E.; Chaurasia, Priyanka; Tan, Hyon-Xhi; Habel, Jennifer R.; Zhang, Wuji; Allen, Lilith F.; Earnest, Linda; Mak, Kai Yan; Juno, Jennifer A.; Wragg, Kathleen; Mordant, Francesca L.; Amanat, Fatima; Krammer, Florian; Mifsud, Nicole A.; Doolan, Denise L.; Flanagan, Katie L.; Sonda, Sabrina; Kaur, Jasveen; Wakim, Linda M.; Westall, Glen P.; James, Fiona; Mouhtouris, Effie; Gordon, Claire L.; Holmes, Natasha E.; Smibert, Olivia C.; Trubiano, Jason A.; Cheng, Allen C.; Harcourt, Peter; Clifton, Patrick; Crawford, Jeremy Chase; Thomas, Paul G.; Wheatley, Adam K.; Kent, Stephen J.; Rossjohn, Jamie; Torresi, Joseph; Kedzierska, Katherine (11 May 2021). "CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity". Immunity. 54 (5): 1066–1082.e5. doi: 10.1016/j.immuni.2021.04.009 . ISSN   1097-4180. PMC   8049468 . PMID   33951417.
• Rowntree, Louise C.; Nguyen, Thi H. O.; Kedzierski, Lukasz; Neeland, Melanie R.; Petersen, Jan; Crawford, Jeremy Chase; Allen, Lilith F.; Clemens, E. Bridie; Chua, Brendon; McQuilten, Hayley A.; Minervina, Anastasia A.; Pogorelyy, Mikhail V.; Chaurasia, Priyanka; Tan, Hyon-Xhi; Wheatley, Adam K.; Jia, Xiaoxiao; Amanat, Fatima; Krammer, Florian; Allen, E. Kaitlynn; Sonda, Sabrina; Flanagan, Katie L.; Jumarang, Jaycee; Pannaraj, Pia S.; Licciardi, Paul V.; Kent, Stephen J.; Bond, Katherine A.; Williamson, Deborah A.; Rossjohn, Jamie; Thomas, Paul G.; Tosif, Shidan; Crawford, Nigel W.; van de Sandt, Carolien E.; Kedzierska, Katherine (12 July 2022). "SARS-CoV-2-specific T cell memory with common TCRαβ motifs is established in unvaccinated children who seroconvert after infection". Immunity. 55 (7): 1299–1315.e4. doi: 10.1016/j.immuni.2022.06.003 . ISSN   1097-4180. PMC   9174177 . PMID   35750048.
• Koutsakos, Marios; Wheatley, Adam K.; Loh, Liyen; Clemens, E. Bridie; Sant, Sneha; Nüssing, Simone; Fox, Annette; Chung, Amy W.; Laurie, Karen L.; Hurt, Aeron C.; Rockman, Steve; Lappas, Martha; Loudovaris, Thomas; Mannering, Stuart I.; Westall, Glen P.; Elliot, Michael; Tangye, Stuart G.; Wakim, Linda M.; Kent, Stephen J.; Nguyen, Thi H. O.; Kedzierska, Katherine (14 February 2018). "Circulating TFH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity". Science Translational Medicine. 10 (428) eaan8405. doi:10.1126/scitranslmed.aan8405. hdl:11343/221875. ISSN   1946-6242. PMID   29444980.
• Wang, Zhongfang; Wan, Yanmin; Qiu, Chenli; Quiñones-Parra, Sergio; Zhu, Zhaoqin; Loh, Liyen; Tian, Di; Ren, Yanqin; Hu, Yunwen; Zhang, Xiaoyan; Thomas, Paul G.; Inouye, Michael; Doherty, Peter C.; Kedzierska, Katherine; Xu, Jianqing (13 May 2015). "Recovery from severe H7N9 disease is associated with diverse response mechanisms dominated by CD8⁺ T cells". Nature Communications. 6 6833. doi: 10.1038/ncomms7833 . ISSN   2041-1723. PMC   4479016 . PMID   25967273.

References

1. "2023 Australian Museum Eureka Prize winners". The Australian Museum. Retrieved 7 May 2025.
2. "Woodward Medallists". The University of Melbourne. 25 September 2024. Retrieved 7 May 2025.
3. "Katherine Kedzierska awarded Selwyn-Smith Medical Research Prize". The University of Melbourne, School of Biomedical Sciences. 18 November 2016. Retrieved 7 May 2025.
4. "Jacques Miller Medal". Australian Academy of Health Sciences. Retrieved 7 May 2025.
5. "Professor Katherine Kedzierska | Doherty Website". www.doherty.edu.au. Retrieved 7 May 2025.
6. "Professor Katherine Kedzierska - AAHMS". aahms.org. Retrieved 7 May 2025.
7. "Professor Katherine Kedzierska | Doherty Website". Doherty Institute, www.doherty.edu.au. Retrieved 7 May 2025.
8. "Prof Katherine Kedzierska". The University of Melbourne, findanexpert.unimelb.edu.au. Retrieved 7 May 2025.
9. "Honorary Staff". HKU Med. Retrieved 7 May 2025.
10. "International Collaboration Unit: Members". Hokkaido University International Institute for Zoonosis Control. Retrieved 7 May 2025.
11. Kedzierska, Katarzyna (December 2001). Mechanisms underlying defective phagocytosis by human monocytes and macrophages following HIV-1 infection (PhD thesis). Monash University. doi:10.4225/03/59ca063ff4133.
12. "2023 Australian Museum Eureka Prize winners". The Australian Museum. Retrieved 7 May 2025.
13. "Prestigious Eureka Prize awarded to Doherty Institute team for pioneering COVID-19 immunity research". Doherty Institute, www.doherty.edu.au. 23 August 2023. Retrieved 7 May 2025.
14. "2018 Woodward Medal in Science and Technology: Prof Katherine Kedzierska". The University of Melbourne, School of Biomedical Sciences. 13 November 2018. Retrieved 8 May 2025.
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16. "Innovators and leading thinkers recognised in Science Academy awards | Australian Academy of Science". Australian Academy of Science. Retrieved 8 May 2025.
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18. Thevarajan, Irani; Nguyen, Thi H. O.; Koutsakos, Marios; Druce, Julian; Caly, Leon; van de Sandt, Carolien E.; Jia, Xiaoxiao; Nicholson, Suellen; Catton, Mike; Cowie, Benjamin; Tong, Steven Y. C.; Lewin, Sharon R.; Kedzierska, Katherine (April 2020). "Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19". Nature Medicine. 26 (4): 453–455. doi:10.1038/s41591-020-0819-2. ISSN   1546-170X. PMC   7095036 . PMID   32284614.
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