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Heroin, also known as diacetylmorphine and diamorphine among other names, is a morphinan opioid substance synthesized from the dried latex of the Papaver somniferum plant; it is mainly used as a recreational drug for its euphoric effects. Medical-grade diamorphine is used as a pure hydrochloride salt. Various white and brown powders sold illegally around the world as heroin are routinely diluted with cutting agents. Black tar heroin is a variable admixture of morphine derivatives—predominantly 6-MAM (6-monoacetylmorphine), which is the result of crude acetylation during clandestine production of street heroin. Heroin is used medically in several countries to relieve pain, such as during childbirth or a heart attack, as well as in opioid replacement therapy.
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Fentanyl is a potent synthetic piperidine opioid primarily used as an analgesic. It is 50 times more potent than heroin and 100 times more potent than morphine; its primary clinical utility is in pain management for cancer patients and those recovering from painful surgeries. Fentanyl is also used as a sedative. Depending on the method of delivery, fentanyl can be very fast acting and ingesting a relatively small quantity can cause overdose. Fentanyl works by activating μ-opioid receptors. Fentanyl is sold under the brand names Actiq, Duragesic and Sublimaze, among others.
Capital punishment is a legal penalty in the U.S. state of Nebraska. In 2015, the state legislature voted to repeal the death penalty, overriding governor Pete Ricketts' veto. However, a petition drive secured enough signatures to suspend the repeal until a public vote. In the November 2016 general election, voters rejected the repeal measure, preserving capital punishment in the state. Nebraska currently has 12 inmates on death row.
Opioids are a class of drugs that derive from, or mimic, natural substances found in the opium poppy plant. Opioids work in the brain to produce a variety of effects, including pain relief. As a class of substances, they act on opioid receptors to produce morphine-like effects.
Pethidine, also known as meperidine and sold under the brand name Demerol among others, is a fully synthetic opioid pain medication of the phenylpiperidine class. Synthesized in 1938 as a potential anticholinergic agent by the German chemist Otto Eisleb, its analgesic properties were first recognized by Otto Schaumann while working for IG Farben, in Germany. Pethidine is the prototype of a large family of analgesics including the pethidine 4-phenylpiperidines, the prodines, bemidones and others more distant, including diphenoxylate and analogues.
Carfentanil or carfentanyl, sold under the brand name Wildnil, is an extremely potent opioid analgesic used in veterinary medicine to anesthetize large animals such as elephants and rhinoceroses. It is typically administered in this context by tranquilizer dart. Carfentanil has also been used in humans to image opioid receptors. It has additionally been used as a recreational drug, typically by injection, insufflation, or inhalation. Deaths have been reported in association with carfentanil.
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Habis Abdulla al Saoub, a.k.a. Abu Tarek, was a Jordanian national and member of the Portland Seven, and later a member of an al Qaeda cell. In February 2003, he was added to the FBI Seeking Information - War on Terrorism list, wanted in connection with a federal grand jury indictment returned on October 3, 2002, in United States District Court for the District of Oregon at Portland, Oregon, in which he was charged with conspiracy to levy war against the United States, conspiracy to provide material support and resources to al-Qaeda, conspiracy to contribute services to al-Qaeda and the Taliban, and possessing firearms in furtherance of crimes of violence. The FBI offered a five million dollar reward for his capture.
Tapentadol, brand names Nucynta among others, is a centrally acting opioid analgesic of the benzenoid class with a dual mode of action as an agonist of the μ-opioid receptor and as a norepinephrine reuptake inhibitor (NRI). Analgesia occurs within 32 minutes of oral administration, and lasts for 4–6 hours.
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Sam Quinones is an American journalist from Los Angeles, California. He is best known for his reporting in Mexico and on Mexicans in the United States, and for his chronicling of the opioid crisis in America through his 2015 book Dreamland, followed by, in 2021, his book, The Least of Us. He has been a reporter for 35 years. He is now a freelance journalist. Prior to that he was a reporter for the Los Angeles Times from 2004 to 2014.
Acetylfentanyl is an opioid analgesic drug that is an analog of fentanyl. Studies have estimated acetylfentanyl to be 15 times more potent than morphine, which would mean that despite being somewhat weaker than fentanyl, it is nevertheless still several times stronger than pure heroin. It has never been licensed for medical use and instead has only been sold on the illicit drug market. Acetylfentanyl was discovered at the same time as fentanyl itself and had only rarely been encountered on the illicit market in the late 1980s. However, in 2013, Canadian police seized 3 kilograms of acetylfentanyl. As a μ-opioid receptor agonist, acetylfentanyl may serve as a direct substitute for oxycodone, heroin or other opioids. Common side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially fatal respiratory depression. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.
There is an ongoing opioid epidemic in the United States, originating out of both medical prescriptions and illegal sources. The epidemic began in the United States in the late 1990s, according to the Centers for Disease Control and Prevention (CDC), when opioids were increasingly prescribed for pain management, resulting in a rise in overall opioid use throughout subsequent years.
The Luppino crime family, also known as the Luppino-Violi crime family, is an 'Ndrangheta organized crime family based and founded in Hamilton, Ontario, Canada, in the 1950s by Giacomo Luppino. The Luppino family is one of three centralized Mafia organizations in Hamilton, with the other two being the Musitano crime family and the Papalia crime family. The Luppinos have had strong connections with the Buffalo crime family of Buffalo, New York.
Thiafentanil is a highly potent opioid analgesic that is an analog of fentanyl, and was invented in 1986. Its analgesic potency is slightly less than that of carfentanil, though with a faster onset of effects, shorter duration of action and a slightly lesser tendency to produce respiratory depression. It is used in veterinary medicine to anesthetise animals such as impala, usually in combination with other anesthetics such as ketamine, xylazine or medetomidine to reduce the prevalence of side effects such as muscle rigidity.
The opioid epidemic, also referred to as the opioid crisis, is the rapid increase in the overuse, misuse/abuse, and overdose deaths attributed either in part or in whole to the class of drugs called opiates/opioids since the 1990s. It includes the significant medical, social, psychological, demographic and economic consequences of the medical, non-medical, and recreational abuse of these medications.
References
- ↑ Steele, Jonathan (3 December 2001). "From rookie reporter to Taliban prisoner". the Guardian.
- ↑ "Well-known Montreal couple face life imprisonment in Nebraska drug case".
- ↑ "Police: Couple invented, cooked, marketed carfentanil, an opioid that 'would pretty much kill you instantly'". Fox 6 Milwaukee. 2019-01-28. Retrieved 2019-11-18.
- ↑ "November 2017 Grand Jury". US Department of Justice. November 27, 2017. Retrieved June 30, 2018.
This article incorporates text from this source, which is in the public domain . - ↑ Hassanzadeh, Erin (2019-01-29). "Busted Omaha drug operation sounds like fiction, except it wasn't". KETV. Retrieved 2021-08-13.
